The DOI matches its Crossref record; 200 of the 200 references it cites were found in a registry or an index.
Sepsis: pathophysiology and clinical management
Abstract
Sepsis, severe sepsis, and septic shock represent increasingly severe systemic inflammatory responses to infection. Sepsis is common in the aging population, and it disproportionately affects patients with cancer and underlying immunosuppression. In its most severe form, sepsis causes multiple organ dysfunction that can produce a state of chronic critical illness characterized by severe immune dysfunction and catabolism. Much has been learnt about the pathogenesis of sepsis at the molecular, cell, and intact organ level. Despite uncertainties in hemodynamic management and several treatments that have failed in clinical trials, investigational therapies increasingly target sepsis induced organ and immune dysfunction. Outcomes in sepsis have greatly improved overall, probably because of an enhanced focus on early diagnosis and fluid resuscitation, the rapid delivery of effective antibiotics, and other improvements in supportive care for critically ill patients. These improvements include lung protective ventilation, more judicious use of blood products, and strategies to reduce nosocomial infections.
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Cites
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Early goal-directed therapy in the treatment of severe sepsis and septic shock
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Surviving Sepsis Campaign: International Guidelines for Management of Severe Sepsis and Septic Shock
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Pattern Recognition Receptors and Inflammation
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Efficacy and Safety of Recombinant Human Activated Protein C for Severe Sepsis
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2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference
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Cited by
Komorowski, M., Celi, L. A., Badawi, O., Gordon, A. C., & Faisal, A. A. (2018) · Nature Medicine · doi:10.1038/s41591-018-0213-5 · Cited by 1,290
Sepsis associated acute kidney injury
Poston, J. T., & Koyner, J. L. (2019) · BMJ · doi:10.1136/bmj.k4891 · Cited by 818
What are the respiratory effects of e-cigarettes?
Gotts, J. E., Jordt, S.-E., McConnell, R., & Tarran, R. (2019) · BMJ · doi:10.1136/bmj.l5275 · Cited by 516
Self-citationThe role of the gut microbiota in sepsis
Haak, B. W., & Wiersinga, W. J. (2017) · The Lancet Gastroenterology & Hepatology · doi:10.1016/s2468-1253(16)30119-4 · Cited by 367
Clinical trials in acute respiratory distress syndrome: challenges and opportunities
Matthay, M. A., McAuley, D. F., & Ware, L. B. (2017) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(17)30188-1 · Cited by 284
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Metadata
- Authors
- Gotts, J. E., & Matthay, M. A.
- Venue
- BMJ
- Publisher
- BMJ
- Published
- 2016-05-23
- Volume
- 353
- Pages
- i1585
- ISSN
- 1756-1833 (ISSN-L)
- OpenAlex
- W2396212074
- Cited by
- 1,243
- References
- 200
- FWCI
- 60.24
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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