The DOI matches its Crossref record; 16 of the 17 references it cites were found in a registry or an index.
Assessment of burden of drug-resistant tuberculosis at a tertiary care centre in northern India: a prospective single centre cohort study
Open accessAbstract
Objectives: We aim to define the burden of rifampicin monoresistant tuberculosis (TB) at a tertiary care centre in northern India as well as determine the second-line drug susceptibilities (SL-DST) in a subset of patients. Methods: A total of 3045 pulmonary (n=1883) and extrapulmonary (n=1162) samples from likely patients with TB were subjected to microscopy, culture and the Xpert MTB/RIF assay from March 2017 to June 2019. SL-DST testing by line probe assay version 2 for fluoroquinolones (FQs) and second-line injectable drugs were performed on 62 samples. Results: Out of 3045 samples processed in our laboratory during the study period, 36.1% (1101/3045) were positive for Mycobacterium tuberculosis complex (MTBC) and 21.6% were rifampicin monoresistant (223/1032). The rate of rifampicin resistance in pulmonary samples was 23.5% (166/706) and in extrapulmonary cases, it was 17.4% (57/326). Out of 62 cases included for second-line testing, 48 were resistant to FQs (77.4%) while 11 were extensively drug resistant. Conclusions: India urgently needs to arrest an emerging multidrug-resistant TB epidemic with associated resistance to FQs. A robust surveillance system is needed to execute the National Strategic Plan for 2017–2025.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Figures
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The cited source says what the claim attributes to it.
In the citing paper
“the study found that the rate of rifampicin resistance among epTB cases was 4.83%, which is lower than the rate reported by previous studies conducted in India by Kant et al.,2018 (13.4%)15, Lohiya et al. 2020 (16%)16, and Misra et al. in 202117.”
From Prevalence of extrapulmonary tuberculosis and factors influencing successful treatment outcomes among notified cases in South India (2025) · cites this paper as [17]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Short, Highly Effective, and Inexpensive Standardized Treatment of Multidrug-resistant Tuberculosis
Deun, A. V., Maug, A. K. J., Salim, M. A. H., Das, P. K., Sarker, M. R., Daru, P., & Rieder, H. L. (2010) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201001-0077oc · Cited by 646
Zeka, A. N., Tasbakan, S., & Cavusoglu, C. (2011) · Journal of Clinical Microbiology · doi:10.1128/jcm.05434-11 · Cited by 362
Mirzayev, F., Viney, K., Linh, N. N., Gonzalez-Angulo, L., Gegia, M., Jaramillo, E., Zignol, M., & Kasaeva, T. (2021) · European Respiratory Journal · doi:10.1183/13993003.03300-2020 · Cited by 301
Marlowe, E. M., Novak-Weekley, S. M., Cumpio, J., Sharp, S. E., Momeny, M. A., Babst, A., Carlson, J. S., Kawamura, M., & Pandori, M. (2011) · Journal of Clinical Microbiology · doi:10.1128/jcm.02214-10 · Cited by 254
Dalal, A., Pawaskar, A., Das, M., Desai, R., Prabhudesai, P., Chhajed, P. N., Rajan, S. K., Reddy, D. N., babu, S. C., Jayalakshmi, T. K., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0116798 · Cited by 86
Prevalence and factors associated with multidrug-resistant tuberculosis in South India
Shivekar, S. S., Kaliaperumal, V., Brammacharry, U., Sakkaravarthy, A., Raj, C. K. V., Alagappan, C., & Muthaiah, M. (2020) · Scientific Reports · doi:10.1038/s41598-020-74432-y · Cited by 84
McDowell, A., & Pai, M. (2016) · The International Journal of Tuberculosis and Lung Disease · doi:10.5588/ijtld.15.0562 · Cited by 81
Prevalence of drug-resistant pulmonary tuberculosis in India: systematic review and meta-analysis
Goyal, V., Kadam, V., Narang, P., & Singh, V. (2017) · BMC Public Health · doi:10.1186/s12889-017-4779-5 · Cited by 75
Drug-resistant tuberculosis: is India ready for the challenge?
Chatterjee, S., Poonawala, H., & Jain, Y. K. (2018) · BMJ Global Health · doi:10.1136/bmjgh-2018-000971 · Cited by 58
Law, S. J., Piatek, A. S., Vincent, C., Oxlade, O., & Menzies, D. (2016) · The Lancet Public Health · doi:10.1016/s2468-2667(16)30035-4 · Cited by 54
Cited by
Tuberculosis challenges: Resistance, co-infection, diagnosis, and treatment
Heidary, M., Shirani, M., Moradi, M., Goudarzi, M., Pouriran, R., Rezaeian, T., & Khoshnood, S. (2022) · European Journal of Microbiology and Immunology · doi:10.1556/1886.2021.00021 · Cited by 76
Diriba, G., Alemu, A., Yenew, B., Tola, H. H., Gamtesa, D. F., Mollalign, H., Eshetu, K., Moga, S., Abdella, S., Tollera, G., et al. (2023) · International Journal of Infectious Diseases · doi:10.1016/j.ijid.2023.04.392 · Cited by 55
VidyaRaj, C. K., Vadakunnel, M. J., Mani, B. R., Anbazhagi, M., Pradhabane, G., Venkateswari, R., Palavesam, S., Venkatesh, K., Usharani, B., Sriramkumar, S. R., et al. (2025) · Scientific Reports · doi:10.1038/s41598-025-92613-5 · Cited by 31
“16 , and Misra et al. in 2021 17 .”
Gupta, A., Paliwal, V. K., Bharatveer, S., Mishra, P., & Jain, N. (2023) · American Journal of Tropical Medicine and Hygiene · doi:10.4269/ajtmh.23-0183 · Cited by 8
Insights into changing patterns of extrapulmonary tuberculosis in North India
Singhal, L., Gupta, P., Aysha, N., & Gupta, V. (2024) · Indian Journal of Medical Microbiology · doi:10.1016/j.ijmmb.2024.100657 · Cited by 8
Metadata
- Authors
- Misra, R., Kesarwani, V., & Nath, A.
- Affiliations
- Sanjay Gandhi Post Graduate Institute of Medical Sciences (IN)
- Corresponding author
- Nath, Alok
- Venue
- BMJ Open
- Publisher
- BMJ
- Published
- 2021-04
- Volume
- 11
- Issue
- 4
- Pages
- e044096
- ISSN
- 2044-6055 (ISSN-L)
- PMC
- PMC8055106
- OpenAlex
- W3155539427
- Cited by
- 14
- References
- 17
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 3 · 2023: 2 · 2022: 2
- FWCI
- 0.55
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- BMJ Open (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Tuberculosis Research and Epidemiology
- Health Sciences › Medicine › Infectious Diseases › Infectious Diseases and Tuberculosis
- Health Sciences › Medicine › Microbiology (medical) › Antibiotic Resistance in Bacteria
- Keywords
- drug-resistant tuberculosis, fluoroquinolone resistance, extensively drug-resistant tuberculosis, Mycobacterium tuberculosis complex, pulmonary tuberculosis, extrapulmonary tuberculosis, tuberculosis surveillance, North India
- MeSH terms
- Humans, India, Microbial Sensitivity Tests, Mycobacterium tuberculosis, Prospective Studies, Sensitivity and Specificity, Cohort Studies, Tuberculosis, Multidrug-Resistant, Drug Resistance, Bacterial, Tertiary Care Centers
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Assessment of burden of drug-resistant tuberculosis at a tertiary care centre in northern India: a prospective single centre cohort study. https://app.cochat.ai/papers/10.1136/bmjopen-2020-044096
- The paper
- Misra, R., Kesarwani, V., & Nath, A. (2021). Assessment of burden of drug-resistant tuberculosis at a tertiary care centre in northern India: a prospective single centre cohort study. BMJ Open. https://doi.org/10.1136/bmjopen-2020-044096
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
