The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Transforming growth factor induced FoxP3+ regulatory T cells suppress Th1 mediated experimental colitis
Open accessAbstract
BACKGROUND AND AIMS: The imbalance between effector and regulatory T cells plays a central role in the pathogenesis of inflammatory bowel diseases. In addition to the thymus, CD4+CD25+ regulatory T cells can be induced in the periphery from a population of CD25- T cells by treatment with transforming growth factor beta (TGF-beta). Here, we analysed the in vivo function of TGF-beta induced regulatory T (Ti-Treg) cells in experimental colitis. METHODS: Ti-Treg cells were generated in cell culture in the presence or absence of TGF-beta and tested for their regulatory potential in experimental colitis using the CD4+CD62L+ T cell transfer model. RESULTS: Ti-Treg cells significantly suppressed Th1 mediated colitis on CD4+CD62L+ T cell transfer in vivo, as shown by high resolution endoscopy, histology, immunohistochemistry, and cytokine analysis. Further analysis of in vivo and in vitro expanded Ti-Treg cells showed that exogenous interleukin 2 (IL-2) was crucial for survival and expansion of these cells. CONCLUSION: Our data suggest that regulatory Ti-Treg cells expand by TGF-beta and exogenous IL-2 derived from effector T cells at the site of inflammation. In addition to Tr1 and thymic CD4+CD25+ T cells, peripheral Ti-Treg cells emerge as a class of regulatory T cells with therapeutic potential in T cell mediated chronic intestinal inflammation.
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Cites
Control of Regulatory T Cell Development by the Transcription Factor Foxp3
Hori, S., Nomura, T., & Sakaguchi, S. (2003) · Science · doi:10.1126/science.1079490 · Cited by 8,187
Cited by
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Geremia, A., Biancheri, P., Allan, P., Corazza, G. R., & Di Sabatino, A. (2014) · Autoimmunity Reviews · doi:10.1016/j.autrev.2013.06.004 · Cited by 982
Benson, M. J., Pino-Lagos, K., Rosemblatt, M., & Noelle, R. J. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20070719 · Cited by 847
DNA methylation controls Foxp3 gene expression
Polansky, J. K., Kretschmer, K., Freyer, J., Floess, S., Garbe, A., Baron, U., Olek, S., Hamann, A., von Boehmer, H., & Huehn, J. (2008) · European Journal of Immunology · doi:10.1002/eji.200838105 · Cited by 785
Mouse models of inflammatory bowel disease☆
WIRTZ, S., & NEURATH, M. (2007) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2007.07.003 · Cited by 507
Regulatory Lymphocytes and Intestinal Inflammation
Izcue, A., Coombes, J. L., & Powrie, F. (2009) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132657 · Cited by 507
Metadata
- Authors
- Fantini, M. C.
- Venue
- Gut
- Publisher
- BMJ
- Published
- 2006-05-01
- Volume
- 55
- Issue
- 5
- Pages
- 671-680
- ISSN
- 0017-5749 (ISSN-L)
- OpenAlex
- W2037284653
- Cited by
- 238
- References
- 1
- FWCI
- 7.51
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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