The DOI matches its Crossref record; 63 of the 63 references it cites were found in a registry or an index.
Predicting relapse in Crohn’s disease: a biopsychosocial model
Abstract
Background: Crohn’s disease (CD) is a chronic relapsing inflammatory bowel disorder. Both biological and psychosocial factors may modulate the illness experience. Aim: The aim of this study was to identify clinical, biological and psychosocial parameters as predictors of clinical relapse in quiescent CD. Methods: Patients in medically induced remission were followed prospectively for 1 year, or less if they relapsed. Disease characteristics were determined at baseline. Serum cytokines, anti- Saccharomyces cerevisiae antibodies, C-reactive protein (CRP), erythrocyte sedimentation rate and intestinal permeability were measured every 3 months. Psychological distress, perceived stress, minor life stressors and coping strategies were measured monthly. A time-dependent multivariate Cox regression model determined predictors of time to relapse. Results: 101 patients (60 females, 41 males) were recruited. Fourteen withdrew and 37 relapsed. CRP (HR = 1.5 per 10 mg/l, 95% CI 1.1 to 1.9, p = 0.007), fistulising disease (HR = 3.2, 95% CI, 1.1 to 9.4, p = 0.04), colitis (HR = 3.5 95% CI 1.2 to 9.9, p = 0.02) and the interaction between perceived stress and avoidance coping (HR = 7.0 per 5 unit increase for both scales, 95% CI 2.3 to 21.8, p = 0.003) were predictors of earlier relapse. Conclusions: In quiescent CD, a higher CRP, fistulising disease behaviour and disease confined to the colon were independent predictors of relapse. Moreover, patients under conditions of low stress and who scored low on avoidance coping (ie, did not engage in social diversion or distraction) were least likely to relapse. This study supports a biopsychosocial model of CD exacerbation.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“When we restricted the analysis to include only the two studies that recruited patients in clinical remission,[20, 26] the risk of flare among those with symptoms of anxiety at baseline was significantly higher (RR = 1.80; 95% CI 1.242.61).”
From Bidirectional brain-gut axis effects influence mood and prognosis in IBD: A systematic review and meta-analysis (2022) · cites this paper as [20]
In the citing paper
“The 13 eligible articles reported on 12 separate study populations,[11, 20-30, 33] containing 9192 patients.”
From Bidirectional brain-gut axis effects influence mood and prognosis in IBD: A systematic review and meta-analysis (2022) · cites this paper as [20]
In the citing paper
“Study quality is provided in Supplementary Tables 1 and 2; five studies scored 7 or more on the NewcastleOttawa scale.[11, 20, 23, 24, 26]”
From Bidirectional brain-gut axis effects influence mood and prognosis in IBD: A systematic review and meta-analysis (2022) · cites this paper as [20]
In the citing paper
“When data were pooled from five studies,[20, 26, 27, 29, 30] containing 1244 patients, the risk of developing a flare of disease activity was no higher among those with symptoms of anxiety at baseline (RR = 1.20; 95% CI 0.93-1.55), with moderate heterogeneity between studies ( I 2 =53.7%).”
From Bidirectional brain-gut axis effects influence mood and prognosis in IBD: A systematic review and meta-analysis (2022) · cites this paper as [20]
In the citing paper
“When data were pooled from eight studies,[20-23, 26, 27, 29, 30] which included 7606 patients, symptoms of depression at baseline were associated with a significantly increased risk of flare of disease activity during longitudinal follow-up (RR = 1.60; 95% CI 1.212.12), with high heterogeneity between studies ( I 2 =73.5%)”
From Bidirectional brain-gut axis effects influence mood and prognosis in IBD: A systematic review and meta-analysis (2022) · cites this paper as [20]
In the citing paper
“However, when the analysis was restricted to include only three studies that recruited only patients in clinical remission,[20, 23, 26] there was no longer a significant increase in risk (RR = 1.36; 95% CI 0.88-2.09).”
From Bidirectional brain-gut axis effects influence mood and prognosis in IBD: A systematic review and meta-analysis (2022) · cites this paper as [20]
Citations
Cites
A Global Measure of Perceived Stress
Cohen, S., Kamarck, T., & Mermelstein, R. (1983) · Journal of Health and Social Behavior · doi:10.2307/2136404 · Cited by 32,807
The Need for a New Medical Model: A Challenge for Biomedicine
Engel, G. L. (1977) · Science · doi:10.1126/science.847460 · Cited by 12,887
(1988) · Cited by 4,111
Folkman, S., & Moskowitz, J. T. (2004) · Annual Review of Psychology · doi:10.1146/annurev.psych.55.090902.141456 · Cited by 3,485
Development of a Crohn's Disease Activity Index
Best, W. R., Becktel, J. M., Singleton, J. W., & Kern, F. (1976) · Gastroenterology · doi:10.1016/s0016-5085(76)80163-1 · Cited by 3,152
Development of a Crohn's disease activity index. National Cooperative Crohn's Disease Study.
Best, W. R., Becktel, J. M., Singleton, J. W., & Kern, F. (1976) · PubMed · Cited by 3,147
Comparison of two modes of stress measurement: Daily hassles and uplifts versus major life events
Kanner, A. D., Coyne, J. C., Schaefer, C. A., & Lazarus, R. S. (1981) · Journal of Behavioral Medicine · doi:10.1007/bf00844845 · Cited by 3,128
Loftus, E. V. (2004) · Gastroenterology · doi:10.1053/j.gastro.2004.01.063 · Cited by 3,106
Stress-induced immune dysfunction: implications for health
Glaser, R., & Kiecolt-Glaser, J. K. (2005) · Nature Reviews Immunology · doi:10.1038/nri1571 · Cited by 2,190
Classification of Inflammatory Bowel Disease
Lennard‐Jones, J. E. (1989) · Scandinavian Journal of Gastroenterology · doi:10.3109/00365528909091339 · Cited by 2,022
Cited by
Sorted by citations
Epidemiology and risk factors for IBD
Ananthakrishnan, A. N. (2015) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2015.34 · Cited by 1,741
Inflammatory bowel disease: Pathogenesis
Zhang, Y.-Z. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i1.91 · Cited by 1,595
Guidelines for the management of inflammatory bowel disease in adults
Mowat, C., Cole, A., Windsor, A. C. J., Ahmad, T., Arnott, I. D., Driscoll, R., Mitton, S. G., Orchard, T. R., Rutter, M. D., Younge, L., et al. (2011) · Gut · doi:10.1136/gut.2010.224154 · Cited by 1,433
Assche, G. V., Dignass, A. U., Reinisch, W., van der Woude, C. J., Sturm, A., Vos, M. D., Guslandi, M., Oldenburg, B., Dotan, I., Marteau, P. R., et al. (2009) · Journal of Crohn s and Colitis · doi:10.1016/j.crohns.2009.09.009 · Cited by 904
Self-citationParacellular permeability and tight junction regulation in gut health and disease
Horowitz, A., Chánez-Paredes, S. D., Haest, X., & Turner, J. R. (2023) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-023-00766-3 · Cited by 748
Metadata
- Authors
- Bitton, A., Dobkin, P. L., Edwardes, M. D., Sewitch, M. J., Meddings, J. B., Rawal, S., Cohen, A., Vermeire, S., Dufresne, L., Franchimont, D., & Wild, G. E.
- Affiliations
- McGill University Health Centre (CA)
- University of Alberta (CA)
- Jewish General Hospital (CA)
- Universitair Ziekenhuis Leuven (BE)
- Douglas Mental Health University Institute (CA)
- Corresponding author
- Bitton, A
- Venue
- Gut
- Publisher
- BMJ
- Published
- 2008-04-07
- Volume
- 57
- Issue
- 10
- Pages
- 1386-1392
- ISSN
- 0017-5749 (ISSN-L)
- 1468-3288
- OpenAlex
- W2028756447
- Cited by
- 254
- References
- 63
- Citations by year
- 2026: 4 · 2025: 14 · 2024: 13 · 2023: 6 · 2022: 18 · 2021: 15 · 2020: 10 · 2019: 14 · 2018: 11 · 2017: 20 · 2016: 17 · 2015: 14 · 2014: 15 · 2013: 21 · 2012: 12
- FWCI
- 9.52
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Gut (publishedVersion)
- PubMed (publishedVersion)
- Dépôt institutionnel de l'Université libre de Bruxelles (Université Libre de Bruxelles) (submittedVersion)
- Topics
- Health Sciences › Medicine › Gastroenterology › Inflammatory Bowel Disease
- Health Sciences › Medicine › Ophthalmology › Ocular Diseases and Behçet’s Syndrome
- Health Sciences › Medicine › Rheumatology › Spondyloarthritis Studies and Treatments
- Keywords
- Crohn's disease, recurrence prediction, biopsychosocial model, C-reactive protein, perceived stress, avoidance coping, colitis, serum cytokines, ASCA, intestinal permeability, psychosocial factors
- MeSH terms
- Adult, Blood Sedimentation, C-Reactive Protein, Crohn Disease, Female, Humans, Male, Models, Psychological, Permeability, Predictive Value of Tests, Prospective Studies, Recurrence, Stress, Psychological, Disease Progression
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
