The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.
Long-term results and risk factor analysis for recurrence after curative endoscopic therapy in 349 patients with high-grade intraepithelial neoplasia and mucosal adenocarcinoma in Barrett’s oesophagus
Abstract
Objective: Endoscopic therapy is increasingly being used in the treatment of high-grade intraepithelial neoplasia (HGIN) and mucosal adenocarcinoma (BC) in patients with Barrett’s oesophagus. This report provides 5 year follow-up data from a large prospective study investigating the efficacy and safety of endoscopic treatment in these patients and analysing risk factors for recurrence. Design: Prospective case series. Setting: Academic tertiary care centre. Patients: Between October 1996 and September 2002, 61 patients with HGIN and 288 with BC were included (173 with short-segment and 176 with long-segment Barrett’s oesophagus) from a total of 486 patients presenting with Barrett’s neoplasia. Patients with submucosal or more advanced cancer were excluded. Interventions: Endoscopic therapy. Main outcome measures: Rate of complete remission and recurrence rate, tumour-associated death. Results: Endoscopic resection was performed in 279 patients, photodynamic therapy in 55, and both procedures in 13; two patients received argon plasma coagulation. The mean follow-up period was 63.6 (SD 23.1) months. Complete response (CR) was achieved in 337 patients (96.6%); surgery was necessary in 13 (3.7%) after endoscopic therapy failed. Metachronous lesions developed during the follow-up in 74 patients (21.5%); 56 died of concomitant disease, but none died of BC. The calculated 5 year survival rate was 84%. The risk factors most frequently associated with recurrence were piecemeal resection, long-segment Barrett’s oesophagus, no ablative therapy of Barrett’s oesophagus after CR, time until CR achieved >10 months and multifocal neoplasia. Conclusions: This study showed that endoscopic therapy was highly effective and safe, with an excellent long-term survival rate. The risk factors identified may help stratify patients who are at risk for recurrence and those requiring more intensified follow-up.
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Cites
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Hospital Volume and Surgical Mortality in the United States
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Surgeon Volume and Operative Mortality in the United States
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Endoscopic mucosal resection for treatment of early gastric cancer
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Pathology and Genetics of Tumours of the Digestive System
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Overholt, B. F., Lightdale, C. J., Wang, K. K., Canto, M. I., Burdick, S., Haggitt, R. C., Bronner, M. P., Taylor, S. L., Grace, M. G. A., & Depot, M. (2005) · Gastrointestinal Endoscopy · doi:10.1016/j.gie.2005.06.047 · Cited by 527
Curative endoscopic resection of early esophageal adenocarcinomas (Barrett's cancer)
Ell, C., May, A., Pech, O., Gossner, L., Guenter, E., Behrens, A., Nachbar, L., Huijsmans, J., Vieth, M., & Stolte, M. (2007) · Gastrointestinal Endoscopy · doi:10.1016/j.gie.2006.04.033 · Cited by 515
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Self-citationMay, A., Gossner, L., Pech, O., Fritz, A., Günter, E., Mayer, G., Müller, H., Seitz, G., Vieth, M., Stolte, M., et al. (2002) · European Journal of Gastroenterology & Hepatology · doi:10.1097/00042737-200210000-00009 · Cited by 364
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Cited by
Pech, O., May, A., Manner, H., Behrens, A., Pohl, J., Weferling, M., Hartmann, U., Manner, N., Huijsmans, J., Gossner, L., et al. (2014) · Gastroenterology · doi:10.1053/j.gastro.2013.11.006 · Cited by 499
Self-citationSikkema, M., de Jonge, P. J. F., Steyerberg, E. W., & Kuipers, E. J. (2010) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2009.10.010 · Cited by 355
Esophageal and Esophagogastric Junction Cancers
Ajani, J. A., Barthel, J. S., Bentrem, D. J., D'Amico, T. A., Das, P., Denlinger, C. S., Fuchs, C. S., Gerdes, H., Glasgow, R. E., Hayman, J. A., et al. (2011) · Journal of the National Comprehensive Cancer Network · doi:10.6004/jnccn.2011.0072 · Cited by 331
Barrett Esophagus and Risk of Esophageal Cancer: A Clinical Review
Spechler, S. J. (2013) · JAMA · doi:10.1001/jama.2013.226450 · Cited by 284
Metadata
- Authors
- Pech, O., Behrens, A., May, A., Nachbar, L., Gossner, L., Rabenstein, T., Manner, H., Guenter, E., Huijsmans, J., Vieth, M., Stolte, M., & Ell, C.
- Venue
- Gut
- Publisher
- BMJ
- Published
- 2008-05-06
- Volume
- 57
- Issue
- 9
- Pages
- 1200-1206
- ISSN
- 0017-5749 (ISSN-L)
- 1468-3288
- OpenAlex
- W1984060133
- Cited by
- 678
- References
- 19
- FWCI
- 55.27
- Type
- journal article
- Language
- en
- Open access
- closed
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