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Cited by 226

Detection of miR-92a and miR-21 in stool samples as potential screening biomarkers for colorectal cancer and polyps

Wu, Chung Wah, Ng, Simon S M, Dong, Yu Juan, Ng, Siew Chien, Leung, Wing Wa, Lee, Chung Wa, Wong, Yee Ni, Chan, Francis K L +2 more·2012·Gut
DOI 10.1136/gut.2011.239236
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Abstract

Objective The detection of molecular markers in stool samples is a potential strategy for colorectal cancer (CRC) screening. This study evaluated the feasibility of detecting miR-21 and miR-92a in stool samples of patients with CRC or polyps. Methods The reproducibility of detection and stability of stool-based microRNA were evaluated. Stool samples were collected from 88 patients with CRC, 57 patients with colorectal polyps and 101 healthy controls. MiRNA levels in CRC tissues and stool samples were detected by real-time quantitative reverse transcription PCR. Stool miR-21 and miR-92a levels were compared before and after the removal of tumour or advanced adenoma. Results The study demonstrated that stool-based miRNA were stable with highly reproducible detection. The expression of miR-21 and miR-92a was significantly higher in CRC tissues compared with their adjacent normal tissues (p Conclusion Stool miRNA are useful for screening CRC and polyps.

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Crossref · 10.1136/gut.2011.239236

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  • Previously reported elevation of epithelial miRNA markers in stool such as hsa-miR-92a-3p and 21-5p could have also stemmed from occult tumor bleeding.

    “Conversely, because of the overlapping expression, previously reported elevation of epithelial miRNA markers in stool such as hsa-miR-92a-3p and 21-5p could have also stemmed from occult tumor bleeding [23].”

    From Novel Approach to Fecal Occult Blood Testing by Assay of Erythrocyte-Specific microRNA Markers (2017) · cites this paper as [23]

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Authors
Wu, C. W., Ng, S. S. M., Dong, Y. J., Ng, S. C., Leung, W. W., Lee, C. W., Wong, Y. N., Chan, F. K. L., Yu, J., & Sung, J. J. Y.
Venue
Gut
Publisher
BMJ
Published
2011-09-19
Volume
61
Issue
5
Pages
739-745
ISSN
  • 0017-5749
  • 1468-3288
DOI
10.1136/gut.2011.239236
Cited by
226
References
0
Language
en

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