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Controlled trial of dexamethasone and mannitol for the cerebral oedema of fulminant hepatic failure.
Open accessAbstract
A controlled trial of 44 patients was undertaken to evaluate the use of dexamethasone (32 mg stat, 8 mg qds) in preventing, and intravenous mannitol (1 g/kg) in reversing the cerebral oedema of fulminant hepatic failure. Diagnosis of cerebral oedema was based on intracranial pressure recordings or the presence of defined clinical signs. Cerebral oedema developed in 34 patients with similar frequency in those treated with and without dexamethasone (16 of 21 and 18 of 23 respectively). In those 34 patients episodes of cerebral oedema resolved significantly more frequently in the 17 patients who received mannitol than in the 17 patients who did not (44 of 53 and 16 of 17 respectively, p less than 0.001). Dexamethasone did not affect survival but among patients who developed cerebral oedema those who received mannitol had a significantly better survival than those who did not receive it (47.1% and 5.9% respectively, p 0.008, Fisher's one-tail test).
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Cited by
EASL Clinical Practical Guidelines on the management of acute (fulminant) liver failure
Wendon, J., Cordoba, J., Dhawan, A., Larsen, F. S., Manns, M., Nevens, F., Samuel, D., Simpson, K. J., Yaron, I., & Bernardi, M. (2017) · Journal of Hepatology · doi:10.1016/j.jhep.2016.12.003 · Cited by 917
Stravitz, R. T., & Lee, W. M. (2019) · The Lancet · doi:10.1016/s0140-6736(19)31894-x · Cited by 844
Controlled trials of charcoal hemoperfusion and prognostic factors in fulminant hepatic failure
O'Grady, J. G., Gimson, A. E. S., O'Brien, C. J., Pucknell, A., Hughes, R. D., & Williams, R. (1988) · Gastroenterology · doi:10.1016/0016-5085(88)90011-x · Cited by 538
Self-citationGuidelines for the Acute Treatment of Cerebral Edema in Neurocritical Care Patients
Cook, A. M., Morgan Jones, G., Hawryluk, G. W. J., Mailloux, P., McLaughlin, D., Papangelou, A., Samuel, S., Tokumaru, S., Venkatasubramanian, C., Zacko, C., et al. (2020) · Neurocritical Care · doi:10.1007/s12028-020-00959-7 · Cited by 447
Stravitz, R. T., Kramer, A. H., Davern, T., Shaikh, A. O. S., Caldwell, S. H., Mehta, R. L., Blei, A. T., Fontana, R. J., McGuire, B. M., Rossaro, L., et al. (2007) · Critical Care Medicine · doi:10.1097/01.ccm.0000287592.94554.5f · Cited by 422
Metadata
- Authors
- Canalese, J., Gimson, A. E., Davis, C., Mellon, P. J., Davis, M., & Williams, R.
- Venue
- Gut
- Publisher
- BMJ
- Published
- 1982-07
- Volume
- 23
- Issue
- 7
- Pages
- 625-629
- ISSN
- 0017-5749 (ISSN-L)
- 1468-3288
- OpenAlex
- W2143531222
- Cited by
- 306
- References
- 0
- FWCI
- 5.94
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Controlled trial of dexamethasone and mannitol for the cerebral oedema of fulminant hepatic failure. https://app.cochat.ai/papers/10.1136/gut.23.7.625
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- Canalese, J., Gimson, A. E., Davis, C., Mellon, P. J., Davis, M., & Williams, R. (1982). Controlled trial of dexamethasone and mannitol for the cerebral oedema of fulminant hepatic failure. Gut. https://doi.org/10.1136/gut.23.7.625
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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