Positive correlation between symptoms and circulating motilin, pancreatic polypeptide and gastrin concentrations in functional bowel disorders.
Open accessAbstract
Motilin, pancreatic polypeptide and gastrin blood concentrations in response to drinking water have been studied in 40 patients with functional bowel disease and compared with results in two groups of healthy control subjects. Patients with slow transit constipation and idiopathic megacolon showed impaired motilin release. Pancreatic polypeptide release was reduced in patients with slow transit constipation, but increased in those with functional diarrhoea. Gastrin release was impaired in all groups complaining of chronic constipation. Circulating motilin, pancreatic polypeptide and gastrin concentrations appear to bear some relationship to intestinal transit time in patients with functional bowel disorders.
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Ginger has been reported to enhance circulating levels of gastrin.
“ginger has been reported to enhance circulating levels of gastrin, which its release seems to be impaired in patients with chronic constipation [37, 38].”
From The effects of ginger supplementation on common gastrointestinal symptoms in patients with relapsing-remitting multiple sclerosis: a double-blind randomized placebo-controlled trial (2023) · cites this paper as [38]
The Results section states that gastrin release was impaired in groups with constipation, supporting the second part of the citing sentence. The paper tested a water load, not ginger, and does not support the attributed claim that ginger enhances circulating gastrin. (LLM, conf=0.88)
Experimental — accuracy not yet measuredGastrin release seems to be impaired in patients with chronic constipation.
“ginger has been reported to enhance circulating levels of gastrin, which its release seems to be impaired in patients with chronic constipation [37, 38].”
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Research works printed but not linked: 17
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Cited by
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Fukui, H., Xu, X., & Miwa, H. (2018) · Journal of Neurogastroenterology and Motility · doi:10.5056/jnm18071 · Cited by 128 · see citing works
Foshati, S., Poursadeghfard, M., Heidari, Z., & Amani, R. (2023) · BMC Complementary Medicine and Therapies · doi:10.1186/s12906-023-04227-x · Cited by 11 · see citing works
“Moreover, ginger has been reported to enhance circulating levels of gastrin, which its release seems to be impaired in patients with chronic constipation [37, 38].”
Background
- Authors
- Preston, D. M., Adrian, T. E., Christofides, N. D., Lennard-Jones, J. E., & Bloom, S. R.
- Affiliations
- St Mark's Hospital (GB)
- Venue
- Gut
- Publisher
- BMJ
- Published
- 1985-10
- Volume
- 26
- Issue
- 10
- Pages
- 1059-1064
- ISSN
- 0017-5749 (ISSN-L)
- 1468-3288
- PMC
- PMC1432940
- OpenAlex
- W2022697288
- Cited by
- 84
- References
- 0
- Citations by year
- 2026: 1 · 2024: 1 · 2023: 3 · 2022: 1 · 2021: 3 · 2020: 1 · 2019: 4 · 2018: 4 · 2015: 3 · 2014: 6 · 2013: 5 · 2012: 1
- FWCI
- 3.62
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Gut (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Health Sciences › Medicine › Surgery › Congenital gastrointestinal and neural anomalies
- Keywords
- motilin, pancreatic polypeptide, gastrin, functional bowel disorders, slow transit constipation, idiopathic megacolon, functional diarrhea, intestinal transit time, gastrointestinal hormones
- MeSH terms
- Adult, Colonic Diseases, Functional, Constipation, Diarrhea, Drinking, Female, Gastrins, Humans, Intestinal Diseases, Male, Megacolon, Middle Aged, Motilin, Pancreatic Polypeptide, Water
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