The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Faecal metronidazole concentrations during oral and intravenous therapy for antibiotic associated colitis due to Clostridium difficile.
Open accessAbstract
Faecal metronidazole and hydroxymetronidazole concentrations measured by high pressure liquid chromatography are reported during 10 episodes of Clostridium difficile colitis in nine patients. Bactericidal faecal concentrations were present in all patients with acute disease receiving oral or intravenous metronidazole, and all responded to therapy. Metronidazole and hydroxymetronidazole concentrations fell as the diarrhoea improved and neither substance was detectable in the faeces of five patients after recovery. This demonstration of intracolonic therapeutic concentrations of metronidazole supports the clinical experience of oral metronidazole being effective in the treatment of antibiotic associated diarrhoea caused by C difficile and also suggests a potential role for intravenous metronidazole in this disease.
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Randomised controlled trial of vancomycin for pseudomembranous colitis and postoperative diarrhoea.
Keighley, M. R., Burdon, D. W., Arabi, Y., Williams, J. A., Thompson, H., Youngs, D., Johnson, M., Bentley, S., George, R. H., & Mogg, G. A. (1978) · BMJ · doi:10.1136/bmj.2.6153.1667 · Cited by 254
ORAL VANCOMYCIN FOR ANTIBIOTIC-ASSOCIATED PSEUDOMEMBRANOUS COLITIS
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Clinical and laboratory observations in Clostridium difficile colitis
Bartlett, J. G., Taylor, N. S., Chang, T., & Dzink, J. (1980) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/33.11.2521 · Cited by 162
Fekety, R., Silva, J., Toshniwal, R., Allo, M. D., Armstrong, J. R., Browne, R., Ebright, J. R., & Rifkin, G. D. (1979) · Clinical Infectious Diseases · doi:10.1093/clinids/1.2.386 · Cited by 134
Treatment and prevention of antimicrobial agent-induced colitis and diarrhea
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Metronidazole: An Alternate Therapy for Antibiotic-Associated Colitis
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Treatment of antibiotic-associated colitis with vancomycin
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Cited by
Guidelines for diagnosis, treatment, and prevention of Clostridium difficile infections
Surawicz, C. M., Brandt, L. J., Binion, D. G., Ananthakrishnan, A. N., Curry, S. R., Gilligan, P. H., McFarland, L. V., Mellow, M., & Zuckerbraun, B. S. (2013) · American Journal of Gastroenterology · doi:10.1038/ajg.2013.4 · Cited by 1,645
Clostridium difficile Infection
Leffler, D. A., & Lamont, J. T. (2015) · New England Journal of Medicine · doi:10.1056/nejmra1403772 · Cited by 1,450
Zar, F. A., Bakkanagari, S. R., Moorthi, K. M. L. S. T., & Davis, M. B. (2007) · Clinical Infectious Diseases · doi:10.1086/519265 · Cited by 1,252
Clostridium Difficile-Associated Diarrhea and Colitis
Gerding, D. N., Johnson, S., Peterson, L. R., Mulligan, M. E., & Silva, J. (1995) · Infection Control & Hospital Epidemiology · doi:10.1086/648363 · Cited by 631
Narrative Review: The New Epidemic of Clostridium difficile–Associated Enteric Disease
Bartlett, J. G. (2006) · Annals of Internal Medicine · doi:10.7326/0003-4819-145-10-200611210-00008 · Cited by 599
Metadata
- Authors
- Bolton, R. P., & Culshaw, M. A.
- Venue
- Gut
- Publisher
- BMJ
- Published
- 1986-10
- Volume
- 27
- Issue
- 10
- Pages
- 1169-1172
- ISSN
- 0017-5749 (ISSN-L)
- 1468-3288
- OpenAlex
- W2150765371
- Cited by
- 320
- References
- 10
- FWCI
- 1.85
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Bolton, R. P., & Culshaw, M. A. (1986). Faecal metronidazole concentrations during oral and intravenous therapy for antibiotic associated colitis due to Clostridium difficile. Gut. https://doi.org/10.1136/gut.27.10.1169
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
