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Improvement of abnormal lactulose/rhamnose permeability in active Crohn's disease of the small bowel by an elemental diet.
Open accessAbstract
Intestinal permeability to sugar has been used as an objective measure of small bowel integrity to assess the efficacy of an elemental diet as the sole treatment or Crohn's disease of the small bowel. Fourteen children aged 11-17 years with active small bowel Crohn's disease were given an elemental diet for six weeks. Investigations with iso-osmolar oral test solutions before and after this treatment showed that all 14 children had abnormally raised lactulose/L-rhamnose permeability ratios, which fell significantly after the elemental diet. This change coincided with marked clinical improvement, as assessed by a disease activity index score.
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Citations
Cited by
Intestinal permeability: an overview
Bjarnason, I., Macpherson, A., & Hollander, D. (1995) · Gastroenterology · doi:10.1016/0016-5085(95)90708-4 · Cited by 927
Michielan, A., & D’Incà, R. (2015) · Mediators of Inflammation · doi:10.1155/2015/628157 · Cited by 709
Is small intestinal permeability really increased in relatives of patients with Crohn's disease?
May, G. R., Sutherland, L. R., & Meddings, J. B. (1993) · Gastroenterology · doi:10.1016/0016-5085(93)90638-s · Cited by 314
Meddings, J. B., & Swain, M. G. (2000) · Gastroenterology · doi:10.1053/gast.2000.18152 · Cited by 269
Miki, K., Butler, R., Moore, D., & Davidson, G. (1996) · Clinical Chemistry · doi:10.1093/clinchem/42.1.71 · Cited by 81
Metadata
- Authors
- Sanderson, I. R., Boulton, P., Menzies, I., & Walker-Smith, J. A.
- Venue
- Gut
- Publisher
- BMJ
- Published
- 1987-09
- Volume
- 28
- Issue
- 9
- Pages
- 1073-1076
- ISSN
- 0017-5749 (ISSN-L)
- 1468-3288
- OpenAlex
- W2123170641
- Cited by
- 170
- References
- 0
- FWCI
- 2.20
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Improvement of abnormal lactulose/rhamnose permeability in active Crohn's disease of the small bowel by an elemental diet. https://app.cochat.ai/papers/10.1136/gut.28.9.1073
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- Sanderson, I. R., Boulton, P., Menzies, I., & Walker-Smith, J. A. (1987). Improvement of abnormal lactulose/rhamnose permeability in active Crohn's disease of the small bowel by an elemental diet. Gut. https://doi.org/10.1136/gut.28.9.1073
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
