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Cited by 163

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Effect of Coffee on Distal Colon Function

Brown, S R, Cann, P A, Read, N W·1990·Gut
DOI 10.1136/gut.31.4.450
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Abstract

Ninety nine healthy young volunteers (58 men, 34 women, aged 17-27 years) answered a questionnaire concerning their bowel habit with particular reference to the effects of beverages. Twenty nine per cent (63% women) claimed that coffee induced a desire to defecate. The rectosigmoid motor responses to black, unsweetened coffee were then investigated by multiport manometry in 14 healthy-subjects (12 men, two women, eight of whom claimed coffee caused a desire to defecate (responders). Results revealed an increase in motility index within four minutes after ingestion of both regular and decaffeinated coffee (p less than 0.05) in the eight responders, but not in the six non-responders. The increase in rectosigmoid motility induced by coffee lasted at least 30 minutes. There was no increase in the motility index in any subject after a drink of hot water. These results suggest that drinking coffee can stimulate a motor response of the distal colon in some normal people.

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Research works printed but not linked: 11

  1. Dennish GW, Castell DO. Caffeine and the lower oesophageal sphincter. AmJ Dig Dis 1972; 17: 993-6. · DOI
  2. Debas HT, Cohen MM, Holubitsky IB, Harrison RC. Caffeine stimulated acid and pepsin secretion: dose response studies. ScandJ Gastroenterol 1971; 6: 453-7. · DOI
  3. Wald A, Back C, Bayless TM. Effect of caffeine on the human small intestine. Gastroenterology 1976; 71: 738-42. · DOI · Paper page
  4. Sun WM, Donnelly TC, Read NW. Anorectal function in normal subjects: the effect of gender. [Abstract]. Gastroenterology 1988; 94: A449.
  5. Acquaviva F, DeFrancesco A, Andriulli A, et al. Effect of regular and decaffinated coffee on serum gastrin levels. J Clin Gastroenterol 1986; 8: 150-3. · DOI · Paper page
  6. Snape WJ, Matarazzo SA, Cohen S. Effect of eating and gastrointestinal hormones on human colonic myoelectrical and motor activity. Gastroenterology 1978; 75: 373-8. · DOI
  7. Renny A, Snape WJ, Sun EA, London R, Cohen S. Role of CCK in the gastrocolonic response to a fat meal. Gastroenterology 1983; 85: 17-21.
  8. Boublik JH, Quinn MJ, Clements JA, Herington AC, Wynne KN, Finder JW. Coffee contains potent opiate receptor binding activity. Nature 1983; 301: 246-8. · DOI
  9. Beuno L, Fioramonti J, Honde C, Fargeas MJ, Primi MP. Central and peripheral control of gastrointestinal and colonic motility by endogenous opiates in conscious dogs. Gastroenterology 1985; 88: 549-56.
  10. Sun EA, Snape WJ, Cohen S, Renny A. The role of Opiate receptors and Cholinergic neurons in the gastrocolonic response. Gastroenterology 1982; 82: 689-93. · DOI
  11. Dinoso VP, Murphy SNS. Variability of intraluminal pressure changes of the distal colon in normal subjects. Gastroenterology 1980; 78: 1157.

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Metadata

Authors
Brown, S. R., Cann, P. A., & Read, N. W.
Venue
Gut
Publisher
BMJ
Published
1990-04
Volume
31
Issue
4
Pages
450-453
ISSN
  • 0017-5749
  • 1468-3288
DOI
10.1136/gut.31.4.450
Cited by
163
References
0
Language
en

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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