The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Role of interleukin-6 in acute pancreatitis. Comparison with C-reactive protein and phospholipase A.
Open accessAbstract
Plasma values of immunoreactive interleukin-6, C-reactive protein and phospholipase A have been determined in serial samples from 24 patients with acute pancreatitis ('mild' pancreatitis nine, 'severe' pancreatitis 15). Median plasma concentrations of interleukin-6, C-reactive protein, and phospholipase A activity were significantly higher in patients with 'severe' illness (p < 0.001) than those with 'mild' illness. A particularly marked increase in interleukin-6 was found in two patients with necrotising pancreatitis and fatal outcome. Significant correlations between plasma concentrations of interleukin-6 and phospholipase A (p = 0.0218) and C-reactive protein and phospholipase A activity (p < 0.0001) were found in patients with 'severe' disease. These findings in a limited number of patients with acute pancreatitis are promising in that raised interleukin-6 correlated with clinical severity and with two other established markers, C-reactive protein, and phospholipase A activity.
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Tissue Destruction by Neutrophils
Epstein, F. H., & Weiss, S. J. (1989) · New England Journal of Medicine · doi:10.1056/nejm198902093200606 · Cited by 3,950
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Mediators of multiple organ failure
Goris, R. J. A. (1990) · Intensive Care Medicine · doi:10.1007/bf01709699 · Cited by 67
Cited by
Inflammatory mediators in human acute pancreatitis: clinical and pathophysiological implications
Mayer, J., Rau, B., Gansauge, F., & Beger, H. G. (2000) · Gut · doi:10.1136/gut.47.4.546 · Cited by 666
Dervenis, C., Johnson, C. D., Bassi, C., Bradley, E., Imrie, C. W., McMahon, M. J., & Modlin, I. (1999) · International journal of pancreatology · doi:10.1007/bf02925968 · Cited by 451
A critical evaluation of laboratory tests in acute pancreatitis
Yadav, D. (2002) · The American Journal of Gastroenterology · doi:10.1016/s0002-9270(02)04122-9 · Cited by 375
IL-6 trans-signaling promotes pancreatitis-associated lung injury and lethality
Zhang, H., Neuhöfer, P., Song, L., Rabe, B., Lesina, M., Kurkowski, M. U., Treiber, M., Wartmann, T., Regnér, S., Thorlacius, H., et al. (2013) · Journal of Clinical Investigation · doi:10.1172/jci64931 · Cited by 288
The role of C-reactive protein as an inflammatory marker in gastrointestinal diseases
Vermeire, S., Van Assche, G., & Rutgeerts, P. (2005) · Nature Clinical Practice Gastroenterology & Hepatology · doi:10.1038/ncpgasthep0359 · Cited by 149
Metadata
- Authors
- Viedma, J. A., Pérez-Mateo, M., Domínguez, J. E., & Carballo, F.
- Venue
- Gut
- Publisher
- BMJ
- Published
- 1992-09
- Volume
- 33
- Issue
- 9
- Pages
- 1264-1267
- ISSN
- 0017-5749 (ISSN-L)
- 1468-3288
- OpenAlex
- W2165889447
- Cited by
- 164
- References
- 3
- FWCI
- 3.23
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Viedma, J. A., Pérez-Mateo, M., Domínguez, J. E., & Carballo, F. (1992). Role of interleukin-6 in acute pancreatitis. Comparison with C-reactive protein and phospholipase A. Gut. https://doi.org/10.1136/gut.33.9.1264
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