The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.
Drinking habits as cofactors of risk for alcohol induced liver damage
Open accessAbstract
Background —The Dionysos Study is a cohort study of the prevalence of chronic liver disease in the general population of two northern Italian communities. It included 6917 subjects, aged 12–65 (69% of the total population). Aims —The aim of this part of the study was to examine the relationship of daily alcohol intake, type of alcoholic beverage consumed, and drinking patterns to the presence of alcohol induced liver damage in an open population. Patients and methods —6534 subjects, free of virus related chronic liver disease and participating in the first cross-sectional part of the study, were fully examined. Each subject underwent: (a) medical history and physical examination, (b) evaluation of alcohol intake using an illustrated dietary questionnaire, and (c) routine blood tests. More invasive diagnostic procedures were performed when indicated. Results —Multivariate analysis showed that the risk threshold for developing either cirrhosis or non-cirrhotic liver damage (NCLD) was ingestion of more than 30 g alcohol per day in both sexes. Using this definition, 1349 individuals (21% of the population studied) were at risk. Of these, only 74 (5.5% of the individuals at risk) showed signs of liver damage. The prevalence of “pure” alcoholic cirrhosis was 0.43% (30 of 6917), representing 2.2% of the individuals at risk, with a ratio of men to women of 9:1, while 44 (3.3% of the individuals at risk) showed persistent signs of NCLD. After 50 years of age, the cumulative risk of developing both NCLD and cirrhosis was significantly higher (p<0.0001) for those individuals who regularly drank alcohol both with and without food than for those who drank only at mealtimes. Conclusions —Our data show that in an open population the risk threshold for developing cirrhosis and NCLD is 30 g ethanol/day, and this risk increases with increasing daily intake. Drinking alcohol outside mealtimes and drinking multiple different alcoholic beverages both increase the risk of developing alcohol induced liver damage.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“These two behaviors have been shown to increase the risk of developing liver cirrhosis in comparison with other alcohol types and drinking patterns [65–67].”
From Liver cirrhosis mortality in 187 countries between 1980 and 2010: a systematic analysis (2014) · cites this paper as [65]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
(1990) · Choice Reviews Online · doi:10.5860/choice.27-3338 · Cited by 35,305
Hosmer, D. W., Lemeshow, S., & Sturdivant, R. X. (2013) · Wiley Series in Probability and Statistics · doi:10.1002/9781118548387 · Cited by 13,861
Kupper, L. L., Hosmer, D. W., & Lemeshow, S. A. (1990) · Journal of the American Statistical Association · doi:10.2307/2290035 · Cited by 7,690
A DATA-BASED APPROACH TO DIET QUESTIONNAIRE DESIGN AND TESTING
Block, G., Hartman, A. M., DRESSER, C. M., Carroll, M. D., Gannon, J. G., & Gardner, L. B. (1986) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a114416 · Cited by 2,150
Toutenburg, H. (1974) · Biometrische Zeitschrift · doi:10.1002/bimj.19740160814 · Cited by 1,547
Frezza, M., di Padova, C., Pozzato, G., Terpin, M., Baraona, E., & Lieber, C. S. (1990) · New England Journal of Medicine · doi:10.1056/nejm199001113220205 · Cited by 1,328
Self-citationPrediction of risk of liver disease by alcohol intake, sex, and age: A prospective population study
Becker, U., Deis, A., Sørensen, T. I. A., Grønbæk, M., Borch‐Johnsen, K., Muller, C. F., Schnohr, P., & Jensen, G. B. (1996) · Hepatology · doi:10.1002/hep.510230513 · Cited by 847
The Validity of Self‐Reported Alcohol Consumption and Alcohol Problems: A Literature Review
Midanik, L. T. (1982) · British Journal of Addiction · doi:10.1111/j.1360-0443.1982.tb02469.x · Cited by 545
Klatsky, A. L., Armstrong, M. A., & FRIEDMAN, G. D. (1992) · Annals of Internal Medicine · doi:10.7326/0003-4819-117-8-646 · Cited by 541
Epidemiology of Alcoholic Liver Disease
Grant, B. F., Dufour, M. C., & Harford, T. C. (1988) · Seminars in Liver Disease · doi:10.1055/s-2008-1040525 · Cited by 536
Flagged first, then by citations
Research works printed but not linked: 4
- Cubean, 1980, La technique du questionnaire alimentaire quantitatif utilise par la section nutrition de l’INSERM., Rev Epidemiol Sante Publique, 28, 367
- Fleiss JL (1981) Statistical methods for rates and proportion. (Wiley and Sons, New York).
- Meier P Beach M (1988) Biostatistics for the clinician. in Data analysis for clinical medicine. ed Chalmer TC (Rome International University Press, Rome), pp 7–29.
- Ascione, 1977, Patologia cronica del fegato in Italia. Inchiesta retrospettiva multicentrica., Rec Prog Med, 63, 447
Cited by
Sorted by citations
Items 201–300 of 628
RAGE promotes dysregulation of iron and lipid metabolism in alcoholic liver disease
Li, Y., Qin, M., Zhong, W., Liu, C., Deng, G., Yang, M., Li, J., Ye, H., Shi, H., Wu, C., et al. (2022) · Redox Biology · doi:10.1016/j.redox.2022.102559 · Cited by 45
Fagan, K. J., Rogers, G. B., Melino, M., Arthur, D. M., Costello, M., Morrison, M., Powell, E. E., & Irvine, K. M. (2015) · PLoS ONE · doi:10.1371/journal.pone.0120642 · Cited by 44
Seitz, H. K., & Mueller, S. (2009) · Springer eBooks · doi:10.1007/978-3-642-04519-6_34 · Cited by 45
Alcohol and the mechanisms of liver disease
Chen, M., Zhong, W., & Xu, W. (2023) · Journal of Gastroenterology and Hepatology · doi:10.1111/jgh.16282 · Cited by 43
Alcohol consumption and risk of fatty liver disease: a meta-analysis
Cao, G.-L., Yi, T., Liu, Q., Wang, M., & Tang, S. (2016) · PeerJ · doi:10.7717/peerj.2633 · Cited by 43
Binge drinking as a risk factor for advanced alcoholic liver disease
Cots, M. V., Watts, A. E., & Bataller, R. (2017) · Liver International · doi:10.1111/liv.13482 · Cited by 43
Maurantonio, M., Ballestri, S., Odoardi, M. R., Lonardo, A., & Loria, P. (2011) · Archives of Medical Research · doi:10.1016/j.arcmed.2011.08.004 · Cited by 40
Alcohol-Associated Pancreatitis
Yadav, D. K., Papachristou, G. I., & Whitcomb, D. C. (2007) · Gastroenterology Clinics of North America · doi:10.1016/j.gtc.2007.03.005 · Cited by 42
Hagström, H., Hegmar, H., & Moreno, C. (2024) · United European Gastroenterology Journal · doi:10.1002/ueg2.12524 · Cited by 40
Biomarkers for detection of alcohol consumption in liver transplantation
Staufer, K., & Yegles, M. (2016) · World Journal of Gastroenterology · doi:10.3748/wjg.v22.i14.3725 · Cited by 41
Emerging concepts in alcoholic hepatitis
Fung, P. C., & Pyrsopoulos, N. (2017) · World Journal of Hepatology · doi:10.4254/wjh.v9.i12.567 · Cited by 41
Osella, A. R., Misciagna, G., Guerra, V., Chiloiro, M., Cuppone, R., Cavallini, A., & Leo, A. D. (2000) · International Journal of Epidemiology · doi:10.1093/ije/29.5.922 · Cited by 40
Jang, S. Y., Kim, I., Ju, E. Y., Ahn, S. J., Kim, D., & Lee, S. W. (2010) · Journal of Public Health · doi:10.1093/pubmed/fdp127 · Cited by 41
Moderate Alcohol Intake in Non-Alcoholic Fatty Liver Disease: To Drink or Not to Drink?
Petroni, M. L., Brodosi, L., Marchignoli, F., Musio, A., & Marchesini, G. (2019) · Nutrients · doi:10.3390/nu11123048 · Cited by 42
Toxic AGE (TAGE) Theory for the Pathophysiology of the Onset/Progression of NAFLD and ALD
Takeuchi, M., Takino, J.-I., Sakai, A., Takata, T., & Tsutsumi, M. (2017) · Nutrients · doi:10.3390/nu9060634 · Cited by 41
“Moreover, alcohol intake outside of mealtimes and the intake of multiple, different beverages were shown to increase the risk of developing ALD [33].”
BackgroundSynergistic and Detrimental Effects of Alcohol Intake on Progression of Liver Steatosis
Ciaula, A. D., Bonfrate, L., Krawczyk, M. J., Frühbeck, G., & Portincasa, P. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23052636 · Cited by 37
Askgaard, G., Kjær, M. S., & Tolstrup, J. S. (2018) · The American Journal of Gastroenterology · doi:10.1038/s41395-018-0282-6 · Cited by 38
KASL Clinical Practice Guidelines: Management of Alcoholic Liver Disease
(2013) · Clinical and Molecular Hepatology · doi:10.3350/cmh.2013.19.3.216 · Cited by 39
“Fatty liver is the most common disease associated with alcohol use, and is seen in 80-90% of heavy drinkers.(52) While full recovery is possible with abstinence at this stage, one study found that continued alcohol use (≥400 g/week) increased the risk of progression to cirrhosis in 30% of cases, and to fibrosis or cir…”
BackgroundInfluentialReview article: the diagnosis and management of alcoholic hepatitis
Cohen, S. M., & Ahn, J. C. (2009) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2009.04002.x · Cited by 38
Non-invasive tests for alcohol-associated liver disease
Israelsen, M. E., Rungratanawanich, W., Thiele, M. S., & Liangpunsakul, S. (2024) · Hepatology · doi:10.1097/hep.0000000000000885 · Cited by 37
“[12,62,63] Both elastography-based and blood-based markers are widely used for assessing liver fibrosis.”
Liu, Z., Que, S., Ning, H., Wang, L., & Peng, T. (2013) · PLoS ONE · doi:10.1371/journal.pone.0080596 · Cited by 38
“With respect to alcohol abuse [35,36], one study [15] evaluated the RR of MetS incidence caused by ALT elevation, excluding subjects with heavy alcohol intake.”
BackgroundPharmacotherapy of alcoholic liver disease in clinical practice
Rosato, V., Abenavoli, L., Federico, A., Masarone, M., & Persico, M. (2015) · International Journal of Clinical Practice · doi:10.1111/ijcp.12764 · Cited by 37
Genetic and Epigenetic Profile of Patients With Alcoholic Liver Disease
Boccuto, L., & Abenavoli, L. (2017) · Annals of Hepatology · doi:10.5604/01.3001.0010.0274 · Cited by 36
McDonald, S., Hutchinson, S. J., Bird, S. M., Graham, L., Robertson, C., Mills, P. R., Hayes, P. C., Dillon, J. F., & Goldberg, D. J. (2009) · Addiction · doi:10.1111/j.1360-0443.2009.02497.x · Cited by 37
Skinner, C., Thompson, A. J., Thursz, M. R., Marchesi, J. R., & Vergis, N. (2020) · Therapeutic Advances in Gastroenterology · doi:10.1177/1756284820942616 · Cited by 37
Incidence rates and causes of cirrhosis in a Norwegian population
Haukeland, J. W., Lorgen, I., Schreiner, L. T., Frigstad, S.-O., Brandsaeter, B. J., Bjøro, K., Bang, C., Raknerud, N., & Konopski, Z. (2007) · Scandinavian Journal of Gastroenterology · doi:10.1080/00365520701478014 · Cited by 36
“, who verified cirrhosis by liver biopsy in all 34 patients who had at least two of three criteria (biochemical, ultrasonographic or clinical signs) indicative of cirrhosis [18].”
BackgroundAlcohol, smoking and the liver disease patient
Hagström, H. (2017) · Best Practice & Research Clinical Gastroenterology · doi:10.1016/j.bpg.2017.09.003 · Cited by 36
“7-fold increased risk for ALD compared to drinking only at mealtimes [22].”
BackgroundNonalcoholic Fatty Liver Disease: Identification and Management of High-Risk Patients
Cheung, A. C., Figueredo, C. J., & Rinella, M. E. (2019) · The American Journal of Gastroenterology · doi:10.14309/ajg.0000000000000058 · Cited by 35
Cho, E. J., Han, K., Lee, S., Shin, D. W., & Yu, S. J. (2020) · Liver International · doi:10.1111/liv.14432 · Cited by 35
A cohort study of the effect of alcohol consumption and obesity on serum liver enzyme levels
Shen, Z., Li, Y., Yu, C., Shen, Y. L., Xu, L., Xu, C., & Xu, G.-Y. (2010) · European Journal of Gastroenterology & Hepatology · doi:10.1097/meg.0b013e3283328b86 · Cited by 35
Correlation of alcohol consumption with liver histological features in non-cirrhotic patients
Kondili, L. A., Taliani, G., Cerga, G., Tosti, M. E., Babameto, A., & Resuli, B. F. (2005) · European Journal of Gastroenterology & Hepatology · doi:10.1097/00042737-200502000-00005 · Cited by 35
Gleeson, D. C., Evans, S., Bradley, M. P., Jones, J., Peck, R. J., Dubé, A., Rigby, E., & Dalton, A. (2006) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2006.00439.x · Cited by 35
TINIAKOS, D. G., Anstee, Q. M., & Burt, A. D. (2017) · Elsevier eBooks · doi:10.1016/b978-0-7020-6697-9.00005-4 · Cited by 35
Im, P. K., Millwood, I. Y., Kartsonaki, C., Chen, Y., Guo, Y., Du, H., Bian, Z., Lan, J., Feng, S., Yu, C., et al. (2021) · International Journal of Cancer · doi:10.1002/ijc.33538 · Cited by 33
“In China, consuming alcohol with meals is much more common than in Western populations (86% vs 50-60%).(49,50) Consistent with Western studies on liver cirrhosis,(49) drinking without meals was associated with excess liver cancer risk in Chinese men, which may be related to the faster absorption of alcohol into the bl…”
BackgroundRussell, M., Pauly, M. P., Moore, C. D., Chia, C., Dorrell, J. M., Cunanan, R. J., Witt, G., & Martin, S. (2012) · Hepatology · doi:10.1002/hep.25755 · Cited by 34
Yamada, T., Fukatsu, M., Suzuki, S., Yoshida, T., Tokudome, S., & Joh, T. (2009) · Digestive Diseases and Sciences · doi:10.1007/s10620-008-0693-0 · Cited by 34
“day prevented cardiovascular diseases and the risk threshold for alcohol-induced liver disease was more than 30 g alcohol/day [34, 35].”
BackgroundAltamirano, J., laTijera, F. H.-D., Duarte‐Rojo, A., Martinez-Vazquez, M. A., Abraldeṣ, J. G., Herrera-Jiménez, L. E., Michelena, J., Zapata, L., Pérez-Hernández, J. L., Torre, A., et al. (2011) · The American Journal of Gastroenterology · doi:10.1038/ajg.2011.141 · Cited by 35
Nonalcoholic fatty liver disease
Grant, L. M., & Lisker‐Melman, M. (2004) · Annals of Hepatology · doi:10.1016/s1665-2681(19)32100-3 · Cited by 34
“Studies show that as little as 20 to 30 g of daily alcohol intake can lead to alcohol induced liver disease.(22,23) In addition, one must ideally rule out other primary liver diseases or any other secondary caus-”
BackgroundLifestyle and Hepatocellular Carcinoma What Is the Evidence and Prevention Recommendations
Zelber‐Sagi, S., Noureddin, M., & Shibolet, O. (2021) · Cancers · doi:10.3390/cancers14010103 · Cited by 33
“Females may develop cirrhosis with less alcohol consumption (20 g/day) than males (60–80 g/day) over the same time (~10 years) [98,108].”
BackgroundGelatti, U., Donato, F., TAGGER, A., Fantoni, C., Portolani, N., Ribero, M. L., Martelli, C., Trevisi, P., Covolo, L., Simonati, C., et al. (2003) · The American Journal of Gastroenterology · doi:10.1016/s0002-9270(02)06011-2 · Cited by 33
Roerecke, M., Nanau, R. M., Rehm, J. T., & Neuman, M. G. (2016) · EBioMedicine · doi:10.1016/j.ebiom.2016.04.023 · Cited by 32
“elevated liver function tests (Bellentani et al., 1997)), e) experimental conditions.”
BackgroundΕvangelou, Ε., Suzuki, H., Bai, W., Pazoki, R., Gao, H., Matthews, P. M., & Elliott, P. (2021) · eLife · doi:10.7554/elife.65325 · Cited by 31
Epigenetic regulation of hepatic stellate cell activation
Mann, D. A., & Mann, J. (2008) · Journal of Gastroenterology and Hepatology · doi:10.1111/j.1440-1746.2007.05295.x · Cited by 32
Alcoholic Hepatitis: A Clinician’s Guide
Choi, G., & Runyon, B. A. (2012) · Clinics in Liver Disease · doi:10.1016/j.cld.2012.03.015 · Cited by 32
Plasma concentrations of zonulin are elevated in obese men with fatty liver disease
Kim, A., & Ko, H. (2018) · Diabetes Metabolic Syndrome and Obesity · doi:10.2147/dmso.s163062 · Cited by 32
“Changes in intestinal permeability are an important mechanism causing severe complications of alcoholic liver diseases.(24) Persson et al(10) reported that alcohol consumption induces malfunction of the intestinal walls and increases intestinal permeability.”
BackgroundArase, Y., Shiraishi, K., Anzai, K., Sato, H., Teramura, E., Tsuruya, K., Hirose, S., Deguchi, R., Toyoda, M., Mine, T., et al. (2019) · Clinical Drug Investigation · doi:10.1007/s40261-019-00785-6 · Cited by 32
Medical comorbidity and alcohol dependence
Mannelli, P., & Pae, C. U. (2007) · Current Psychiatry Reports · doi:10.1007/s11920-007-0022-x · Cited by 31
“In large, prospective cohort studies, the minimum alcohol intake associated with a significant increase in the prevalence of liver disease was 30 g/d in both sexes [ 26 ].”
BackgroundDakeishi, M., Murata, K., Tamura, A., & Iwata, T. (2006) · Risk Analysis · doi:10.1111/j.1539-6924.2006.00722.x · Cited by 31
Shen, Z., Li, Y., Yu, C., Shen, Y. L., Xu, L., Xu, C., Chen, J., Ye, H., & Xu, G.-Y. (2008) · World Journal of Gastroenterology · doi:10.3748/wjg.14.2255 · Cited by 30
Advances in alcoholic liver disease: An update on alcoholic hepatitis
Liang, R. (2015) · World Journal of Gastroenterology · doi:10.3748/wjg.v21.i42.11893 · Cited by 30
Siddiqui, M. S., & Charlton, M. (2016) · Gastroenterology · doi:10.1053/j.gastro.2016.02.077 · Cited by 30
Lourens, S. G., Sunjaya, D. B., Singal, A. K., Liangpunsakul, S., Puri, P., Sanyal, A. J., Ren, X., Gores, G. J., Radaeva, S., Chalasani, N., et al. (2017) · Mayo Clinic Proceedings Innovations Quality & Outcomes · doi:10.1016/j.mayocpiqo.2017.04.004 · Cited by 30
Outpatient management of alcohol-related liver disease
Simonetto, D. A., Shah, V. H., & Kamath, P. S. (2020) · The Lancet. Gastroenterology & hepatology · doi:10.1016/s2468-1253(19)30415-7 · Cited by 30
Dose‐dependent relationship between social drinking and brain aging
Angebrandt, A., Abulseoud, O. A., Kisner, M. A., Diazgranados, N., Momenan, R., Yang, Y., Stein, E. A., & Ross, T. J. (2021) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2021.11.008 · Cited by 30
Brief Report: Genetics of Alcoholic Cirrhosis— G enom ALC Multinational Study
Whitfield, J. B., Rahman, K., Haber, P., Day, C. P., Masson, S., Daly, A. K., Cordell, H. J., Mueller, S., Seitz, H. K., Liangpunsakul, S., et al. (2015) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.12693 · Cited by 30
“The reasons for this variation in susceptibility to liver damage, apart from quantity of alcohol and sex differences (Becker et al., 1996; Bellentani et al., 1997; Pequignot et al., 1978; Tuyns and Pequignot, 1984) and perhaps obesity (Iturriaga et al.”
Cassiman, D. M., & Jaeken, J. (2008) · Gut · doi:10.1136/gut.2007.123240 · Cited by 30
Dietary fatty acids and bioactive fatty acid metabolites in alcoholic liver disease
Zirnheld, K. H., Warner, D. R., Warner, J. B., Hardesty, J., McClain, C. J., & Kirpich, I. (2019) · Liver Research · doi:10.1016/j.livres.2019.10.001 · Cited by 29
Association between Metabolic Dysfunction-associated Fatty Liver Disease and Cognitive Impairment
Yu, Q., He, R., Jiang, H., Wu, J., Xi, Z., He, K., Liu, Y., Zhou, T., Feng, M., Wan, P., et al. (2022) · Journal of Clinical and Translational Hepatology · doi:10.14218/jcth.2021.00490 · Cited by 29
Tao, N., Sussman, S. Y., Nieto, J. M., Tsukamoto, H., & Yuan, J. (2003) · Alcoholism Clinical and Experimental Research · doi:10.1097/01.alc.0000095862.30777.d9 · Cited by 29
Alcoholic Liver Disease: From Pathophysiology to Therapy
Seitz, H. K., Lieber, C. S., Stickel, F., Salaspuro, M. P., SCHLEMMER, H., & Horie, Y. (2005) · Alcoholism Clinical and Experimental Research · doi:10.1097/01.alc.0000171896.37022.f7 · Cited by 29
Alcohol Use, Vascular Disease, and Lipid-Lowering Drugs
Kolovou, G. D., Salpea, K. D., Anagnostopoulou, K. K., & Mikhailidis, D. P. (2006) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.106.102269 · Cited by 29
“The Italian Dionysos study showed that Alc is suspected to cause the 23% of all cases of liver disease, with a dose-dependent increase in the risk of developing liver disease (Bellentani et al., 1997).”
BackgroundLiver transplantation for alcoholic liver disease
Burra, P., & Lucey, M. R. (2013) · Clinical Liver Disease · doi:10.1002/cld.204 · Cited by 29
Alcohol Consumption and Liver Disease in Australia: A Time Series Analysis of the Period 1935–2006
Jiang, H., Livingston, M., Room, R., Dietze, P., Norström, T., & Kerr, W. C. (2013) · Alcohol and Alcoholism · doi:10.1093/alcalc/agt143 · Cited by 27
“This fits with previous research implicating drinking pattern above and beyond drinking volume as a risk factor for liver disease (Bellentani et al., 1997).”
BackgroundPhysiological processes underlying organ injury in alcohol abuse
Souza‐Smith, F. M., Lang, C. H., Nagy, L. E., Bailey, S. M., Parsons, L. H., & Murray, G. J. (2016) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00270.2016 · Cited by 28
Survey of health status, nutrition and geography of food selection of chronic liver disease patients
Leslie, T. F., Pawloski, L. R., Kallman-Price, J., Escheik, C., Hossain, N., Fang, Y. H., Gerber, L. H., & Younossi, Z. M. (2014) · Annals of Hepatology · doi:10.1016/s1665-2681(19)31253-0 · Cited by 28
Does an association exist between chronic pancreatitis and liver cirrhosis in alcoholic subjects?
Aparisi, L., Sabater-Orti, L., Del-Olmo, J., Sastre, J., Serra, M.-A., Campello, R., Bautista, D., Wassel, A., & Rodrigo, J.-M. (2008) · World Journal of Gastroenterology · doi:10.3748/wjg.14.6171 · Cited by 28
Xiao, J., Lv, Y., Lin, B., Tipoe, G. L., Youdim, M. B. H., Xing, F., & Liu, Y. (2015) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2015/607271 · Cited by 27
Dai, W., Chen, C., Feng, H., Li, G., Peng, W., Liu, X., Yang, J., & Hu, X. (2021) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2021.114140 · Cited by 27
Detection of alcoholic liver disease
Gordon, H. (2001) · World Journal of Gastroenterology · doi:10.3748/wjg.v7.i3.297 · Cited by 27
Aday, A. W., Mitchell, M. C., & Casey, L. C. (2017) · Current Opinion in Gastroenterology · doi:10.1097/mog.0000000000000359 · Cited by 27
Glutathione and Transsulfuration in Alcohol-Associated Tissue Injury and Carcinogenesis
Chen, Y., Han, M., Matsumoto, A., Wang, Y., Thompson, D. C., & Vasiliou, V. (2018) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-98788-0_3 · Cited by 27
“Chronic ethanol consumption can cause a spectrum of ALDs, which clinically can manifest as steatosis, steatohepatitis, fibrosis, and cirrhosis [57].”
BackgroundBrunt, E. M., Neuschwander‐Tetri, B. A., & Burt, A. D. (2011) · Elsevier eBooks · doi:10.1016/b978-0-7020-3398-8.00006-4 · Cited by 27
Effects of Alcohol Consumption on Hepatocellular Injury in Japanese Men
Dakeishi, M., Iwata, T., Ishii, N. K., & Murata, K. (2004) · The Tohoku Journal of Experimental Medicine · doi:10.1620/tjem.202.31 · Cited by 27
Chronic plus binge ethanol exposure causes more severe pancreatic injury and inflammation
Ren, Z., Yang, F., Wang, X., Wang, Y., Xu, M., Frank, J. A., Ke, Z., Zhang, Z., Shi, X., & Luo, J. (2016) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2016.08.012 · Cited by 26
Warner, J. B., Zirnheld, K. H., Hu, H., Floyd, A., Kong, M., McClain, C. J., & Kirpich, I. (2022) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.14944 · Cited by 27
Cramer, J. D., Patel, U. A., Samant, S., Yang, A., & Smith, S. S. (2016) · The Laryngoscope · doi:10.1002/lary.26044 · Cited by 26
Nielsen, J. K., Ólafsson, S., Bergmann, O. M., Rúnarsdóttir, V. Á., Hansdóttir, I., Sigurdardóttir, R., & Bjornsson, E. S. (2017) · Scandinavian Journal of Gastroenterology · doi:10.1080/00365521.2017.1295466 · Cited by 26
Association between liver enzymes and bone mineral density in Koreans: a cross-sectional study
Do, H. J., Shin, J., Lee, J., Lee, Y. J., Kim, M.-R., Nam, D., Kim, E., Park, Y., Suhr, K., & Ha, I. (2018) · BMC Musculoskeletal Disorders · doi:10.1186/s12891-018-2322-1 · Cited by 27
Hsu, M.-F., Koike, S., Mello, A., Nagy, L. E., & Haj, F. G. (2020) · Redox Biology · doi:10.1016/j.redox.2020.101658 · Cited by 25
Adams, L. A., Angulo, P., Abraham, S. C., Torgerson, H., & Brandhagen, D. J. (2006) · Liver International · doi:10.1111/j.1478-3231.2005.01238.x · Cited by 26
“Current or previous consumption of six or more standard drinks per day on a regular basis was classified as heavy alcohol consumption (12).”
BackgroundPiñero, F., Tanno, M., Soteras, G. A. A., Baña, M. T., Dirchwolf, M., Fassio, E., Ruf, A. E., Mengarelli, S., Borzi, S. M., Fernández, N., et al. (2020) · Annals of Hepatology · doi:10.1016/j.aohep.2020.06.003 · Cited by 25
Asharani, P. V., Karuvetil, M. Z., Brian, T. Y. W., Satghare, P., Roystonn, K., Wang, P., Cetty, L., Zainuldin, N. A. B., & Subramaniam, M. (2022) · International Journal of Mental Health and Addiction · doi:10.1007/s11469-021-00734-5 · Cited by 24
“The risk is 7 times higher in people who consume 50 g/day and > 26 times for those who take 100 g of alcohol per day (Bellentani et al., 1997).”
BackgroundDerdák, Z., Villegas, K. A., & Wands, J. R. (2012) · Liver International · doi:10.1111/j.1478-3231.2012.02752.x · Cited by 24
Alcohol-related hepatitis: A review article
Chaudhry, H., Sohal, A., Iqbal, H., & Roytman, M. M. (2023) · World Journal of Gastroenterology · doi:10.3748/wjg.v29.i17.2551 · Cited by 23
Markers of Inflammation and Mortality in a Cohort of Patients With Alcohol Dependence
Fuster, D., Sanvisens, A., Bolao, F., Zuluaga, P., Rivas, I., Tor, J., & Muga, R. (2015) · Medicine · doi:10.1097/md.0000000000000607 · Cited by 23
Outcome of patients with liver cirrhosis admitted to a specialty liver intensive care unit in India
Juneja, D., Gopal, P. B. N., Kapoor, D., Raya, R., Sathyanarayanan, M., & Malhotra, P. (2009) · Journal of Critical Care · doi:10.1016/j.jcrc.2008.12.013 · Cited by 23
Multipotent mesenchymal stromal cells: A promising strategy to manage alcoholic liver disease
Ezquer, F. E. (2015) · World Journal of Gastroenterology · doi:10.3748/wjg.v22.i1.24 · Cited by 23
Assessment of donor steatosis in liver transplantation: is it possible without liver biopsy?
Cucchetti, A., Vivarelli, M., Ravaioli, M., Cescon, M., Ercolani, G., Piscaglia, F., Gaudio, M. D., Grazi, G. L., Ridolfi, L., & Pinna, A. D. (2009) · Clinical Transplantation · doi:10.1111/j.1399-0012.2009.00987.x · Cited by 22
Shen, Y., Zhao, Y., Zhong, C., Huang, H., Yang, Z., Wu, M., Lu, L., Yang, R., & Ke, X. (2024) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2024.117790 · Cited by 20
Alcohol consumption in patients with primary sclerosing cholangitis
Hagström, H. (2012) · World Journal of Gastroenterology · doi:10.3748/wjg.v18.i24.3105 · Cited by 21
Chronic hepatitis B and liver schistosomiasis: a deleterious association
de Andrade, J. R. A., Silva, L. D., Guimaraes, C. M., Soares, E. B., de Miranda, R. R. C., Couto, O. F. M., & Teixeira, R. (2014) · Transactions of the Royal Society of Tropical Medicine and Hygiene · doi:10.1093/trstmh/tru010 · Cited by 21
Alcoholic Hepatitis: Risk Factors, Pathogenesis, and Approach to Treatment
Yeluru, A., Cuthbert, J. A., Casey, L. C., & Mitchell, M. C. (2016) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.12956 · Cited by 21
Survey of alcohol-related cirrhosis at a tertiary care center in North East India
Bhattacharyya, M., Barman, N. N., & Goswami, B. (2016) · Indian Journal of Gastroenterology · doi:10.1007/s12664-016-0651-2 · Cited by 21
Ye, X., Wang, X., Shang, L., Zhu, G., Su, H., Han, C., Qin, W., Li, G., & Peng, T. (2018) · Cancer Management and Research · doi:10.2147/cmar.s162105 · Cited by 21
“Alcohol intake varies among cultures, but is prevalent around the world and likely to induce alcohol dependence in heavy drinkers, which account for approximately 14% of the general population,(4) approximately 10–15% of whom are at high risk of liver cirrhosis, including a small percentage at an exceptional risk for…”
Willner, I. R., & Reuben, A. (2005) · Current Opinion in Internal Medicine · doi:10.1097/01.mog.0000160044.87933.87 · Cited by 21
Hepatitis C Virus Genotypes and Risk of Cirrhosis in Southern Italy
Osella, A. R., Misciagna, G., Guerra, V., Elba, S., Buongiorno, G., Cavallini, A., Leo, A. D., Sonzogni, L., Mondelli, M. U., & Silini, E. M. (2001) · Clinical Infectious Diseases · doi:10.1086/320887 · Cited by 21
“Therefore, in addition to overall levels of alcohol intake, modalities of consumption and the typical Mediterranean diet might be important with regard to the modulation of liver damage due to alcohol [28].”
BackgroundAlcoholic Hepatitis: Current Management
Spengler, E. K., Dunkelberg, J. C., & Schey, R. (2014) · Digestive Diseases and Sciences · doi:10.1007/s10620-014-3173-8 · Cited by 21
Fuster, D., Tsui, J. I., Cheng, D. M., Quinn, E. K., Bridden, C. L., Nunes, D., Libman, H., Saitz, R., & Samet, J. H. (2013) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.12129 · Cited by 20
The role of FABP2 gene polymorphism in alcoholic cirrhosis
Salguero, M. L., LEON, R., Santos, A., Román, S., Segura‐Ortega, J. E., & Panduro, A. (2005) · Hepatology Research · doi:10.1016/j.hepres.2005.09.037 · Cited by 20
Health Consequences of Adolescent Alcohol Involvement
Bonnie, R. J., O’Connell, M. E., & UnderageDrinking, P. (2004) · Cited by 20
Metadata
- Authors
- Bellentani, S., Saccoccio, G., Costa, G., Tiribelli, C., Manenti, F., Sodde, M., Croce’, L. S., Sasso, F., Pozzato, G., Cristianini, G., & Brandi and the Dionysos Study Group, G.
- Affiliations
- Fondo per lo Studio delle Malattie del Fegato, Trieste and Modena, Italy
- Corresponding author
- Bellentani, S
- Venue
- Gut
- Publisher
- BMJ
- Published
- 1997-12-01
- Volume
- 41
- Issue
- 6
- Pages
- 845-850
- ISSN
- 0017-5749 (ISSN-L)
- 1468-3288
- PMC
- PMC1891602
- OpenAlex
- W2135155547
- Cited by
- 630
- References
- 40
- Citations by year
- 2026: 3 · 2025: 9 · 2024: 13 · 2023: 22 · 2022: 23 · 2021: 26 · 2020: 27 · 2019: 26 · 2018: 39 · 2017: 31 · 2016: 38 · 2015: 44 · 2014: 43 · 2013: 31 · 2012: 30
- FWCI
- 4.38
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Gut (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- ArTS Archivio della ricerca di Trieste (University of Trieste https://www.units.it/) (submittedVersion)
- HighWire Press Open Archive (submittedVersion)
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
- Health Sciences › Medicine › Hepatology › Liver Disease Diagnosis and Treatment
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Keywords
- alcohol-induced liver damage, alcoholic cirrhosis, daily drinking, drinking patterns, risk thresholds, sex differences, age-related risk
- MeSH terms
- Adolescent, Adult, Age Factors, Aged, Alcohol Drinking, Alcoholic Beverages, Child, Chronic Disease, Female, Humans, Italy, Liver Cirrhosis, Alcoholic, Liver Diseases, Alcoholic, Male, Middle Aged, Risk, Sex Factors, Cohort Studies, Prevalence, Multivariate Analysis
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
