The DOI matches its Crossref record; 46 of the 46 references it cites were found in a registry or an index.
Microsatellite instability and the clinicopathological features of sporadic colorectal cancer
Open accessAbstract
BACKGROUND AND AIMS: In this study, we prospectively examined the clinical significance of the microsatellite instability (MSI) phenotype in sporadic colorectal cancer, and investigated methods for effective identification of these tumours in routine pathology practice. METHODS: DNA was extracted from 310 tumours collected from 302 consecutive individuals undergoing curative surgery for sporadic colorectal cancer. Microsatellite status was determined by polymerase chain reaction amplification using standard markers, while immunostaining was used to examine expression of MLH1, MSH2, and p53. RESULTS: Eleven per cent of tumours showed high level instability (MSI-H), 6.8% had low level instability (MSI-L), and the remainder were stable. MSI-H tumours were significantly more likely to be of high histopathological grade, have a mucinous phenotype, and to harbour increased numbers of intraepithelial lymphocytes. They were also more likely to be right sided, occur in women, and be associated with improved overall survival. In total, 25 (8%) tumours showed loss of staining for MLH1 and a further three tumours showed absence of staining for MSH2. The positive and negative predictive value of immunohistochemistry in the detection of MSI-H tumours was greater than 95%. CONCLUSIONS: We conclude that the MSI-H phenotype constitutes a pathologically and clinically distinct subtype of sporadic colorectal cancer. Immunohistochemical staining for MLH1 and MSH2 represents an inexpensive and accurate means of identifying such tumours.
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Microsatellite Instability in Cancer of the Proximal Colon
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The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer
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Tumor Microsatellite Instability and Clinical Outcome in Young Patients with Colorectal Cancer
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Microsatellite Instability in Colorectal Cancer
Boland, C. R., & Goel, A. (2010) · Gastroenterology · doi:10.1053/j.gastro.2009.12.064 · Cited by 2,456
Epigenetic Alterations in Colorectal Cancer: Emerging Biomarkers
Okugawa, Y., Grady, W. M., & Goel, A. (2015) · Gastroenterology · doi:10.1053/j.gastro.2015.07.011 · Cited by 782
Mucins and mucin binding proteins in colorectal cancer
Byrd, J. C., & Bresalier, R. S. (2004) · Cancer and Metastasis Reviews · doi:10.1023/a:1025815113599 · Cited by 490
Jenkins, M. A., Hayashi, S., O’Shea, A.-M., Burgart, L. J., Smyrk, T. C., Shimizu, D., Waring, P. M., Ruszkiewicz, A. R., Pollett, A. F., Redston, M., et al. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.04.044 · Cited by 373
Biomarker-guided therapy for colorectal cancer: strength in complexity
Sveen, A., Kopetz, S., & Lothe, R. A. (2020) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-019-0241-1 · Cited by 320
Metadata
- Authors
- Ward, R., Meagher, A., Tomlinson, I., O'Connor, T., Norrie, M., Wu, R., & Hawkins, N.
- Venue
- Gut
- Publisher
- BMJ
- Published
- 2001-06-01
- Volume
- 48
- Issue
- 6
- Pages
- 821-829
- ISSN
- 0017-5749 (ISSN-L)
- 1468-3288
- OpenAlex
- W2127330908
- Cited by
- 384
- References
- 46
- FWCI
- 14.95
- Type
- journal article
- Language
- en
- Open access
- bronze
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