The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.
Cost effectiveness of adjuvant therapy for hepatocellular carcinoma during the waiting list for liver transplantation
Open accessAbstract
BACKGROUND: Survival after liver transplantation for early hepatocellular carcinoma (HCC) is worsened by the increasing dropout rate while waiting for a donor. AIMS: To assess the cost effectiveness of adjuvant therapy while waiting for liver transplantation in HCC patients. METHOD: Using a Markov model, a hypothetical cohort of cirrhotic patients with early HCC was considered for: (1) adjuvant treatment-resection was limited to Child-Pugh's A patients with single tumours, and percutaneous treatment was considered for Child-Pugh's A and B patients with single tumours unsuitable for resection or with up to three nodules < 3 cm; and (2) standard management. Length of waiting time ranged from six to 24 months. RESULTS: Surgical resection increased the transplantation rate (>10%) and provided gains in life expectancy of 4.8-6.1 months with an acceptable cost ($40,000/ year of life gained) for waiting lists > or = 1 year whereas it was not cost effective ($74,000/life of year gained) for shorter waiting times or high dropout rate scenarios. Percutaneous treatment increased life expectancy by 5.2-6.7 months with a marginal cost of approximately $20,000/year of life gained in all cases, remaining cost effective for all waiting times. CONCLUSIONS: Adjuvant therapies for HCC while waiting for liver transplantation provide moderate gains in life expectancy and are cost effective for waiting lists of one year or more. For shorter waiting times, only percutaneous treatment confers a relevant survival advantage.
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Five‐Hundred Life‐Saving Interventions and Their Cost‐Effectiveness
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Small Hepatocellular Carcinoma: Treatment with Radio-frequency Ablation versus Ethanol Injection
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Self-citationThe Role of Cost-effectiveness Analysis in Health and Medicine
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Cited by
EASL Clinical Practice Guidelines: Management of hepatocellular carcinoma
Galle, P. R., Forner, A., Llovet, J. M., Mazzaferro, V., Piscaglia, F., Raoul, J.-L., Schirmacher, P., & Vilgrain, V. (2018) · Journal of Hepatology · doi:10.1016/j.jhep.2018.03.019 · Cited by 11,406
Self-citationEASL–EORTC Clinical Practice Guidelines: Management of hepatocellular carcinoma
European Association for the Study of the Liver, & European Organisation for Research and Treatment of Cancer (2012) · Journal of Hepatology · doi:10.1016/j.jhep.2011.12.001 · Cited by 5,218
Villanueva, A. (2019) · New England Journal of Medicine · doi:10.1056/nejmra1713263 · Cited by 4,508
EASL Clinical Practice Guidelines: Liver transplantation
(2016) · Journal of Hepatology · doi:10.1016/j.jhep.2015.10.006 · Cited by 1,082
Llovet, J. M., Vilana, R., Brú, C., Bianchi, L., Salmeron, J. M., Boix, L., Ganau, S., Sala, M., Pagès, M., Ayuso, C., et al. (2001) · Hepatology · doi:10.1053/jhep.2001.24233 · Cited by 759
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Metadata
- Authors
- Llovet, J. M.
- Venue
- Gut
- Publisher
- BMJ
- Published
- 2002-01-01
- Volume
- 50
- Issue
- 1
- Pages
- 123-128
- ISSN
- 0017-5749 (ISSN-L)
- OpenAlex
- W2158179682
- Cited by
- 287
- References
- 35
- FWCI
- 12.14
- Type
- journal article
- Language
- en
- Open access
- bronze
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