Hepatic stellate cells: role in microcirculation and pathophysiology of portal hypertension
Open accessAbstract
Accumulating evidence suggests that stellate cells are involved in the regulation of the liver microcirculation and portal hypertension. Activated hepatic stellate cells have the necessary machinery to contract or relax in response to a number of vasoactive substances. Because stellate cells play a role in both fibrosis and portal hypertension, they are currently regarded as therapeutic targets to prevent and treat the complications of chronic liver disease.
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Hepatic stellate cells profoundly change their phenotype when transdifferentiating into myofibroblasts, marked by increased capacity for chemotaxis, fibrogenesis, contractility and loss of cytoplasmic retinoids.
“Importantly, HSCs profoundly change their phenotype when transdifferentiating into MFs marked by an increased capacity for chemotaxis, fibrogenesis, contractility and a loss of cytoplasmatic retinoids.[5]”
From Nuclear receptors in liver fibrosis (2021) · cites this paper as [5]
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References 159 · Cited by 289
Research works printed but not linked: 4
- Ramadori G. The stellate cell of the liver. Virchows Arch B Cell Pathol 1991;61:147-58.
- McCuskey RS, Ito Y, McCuskey M, et al. Morphological mechanisms for regulating blood flow through hepatic sinusoids. In: Wisse E, Knook DL, Fraser R, eds. Cells of the hepatic sinusoid, 7th edn. Leiden: Kupffer Cell Foundation, 1999 (1998 update and review):129-34.
- Reynaert, Thompson, Thomas, et al www.gutjnl.com on July 23, 2023 by guest. Protected by copyright. http://gut.bmj.com/ Gut: first published as 10.1136/gut.50.4.571 on 1 April 2002. Downloaded from 142
- www.gutjnl.com on July 23, 2023 by guest. Protected by copyright. http://gut.bmj.com/ Gut: first published as 10.1136/gut.50.4.571 on 1 April 2002. Downloaded
- Authors
- Reynaert, H., Thompson, M. G., Thomas, T., & Geerts, A.
- Affiliations
- Vrije Universiteit Brussel (BE)
- Newcastle University (GB)
- Corresponding author
- Reynaert, H
- ORCID
- Reynaert, H
- Venue
- Gut
- Publisher
- BMJ
- Published
- 2002-04
- Volume
- 50
- Issue
- 4
- Pages
- 571-581
- ISSN
- 0017-5749 (ISSN-L)
- 1468-3288
- PMC
- PMC1773176
- OpenAlex
- W2164864100
- Cited by
- 289
- References
- 159
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 9 · 2023: 11 · 2022: 10 · 2021: 11 · 2020: 18 · 2019: 11 · 2018: 9 · 2017: 9 · 2016: 9 · 2015: 21 · 2014: 10 · 2013: 14 · 2012: 13
- FWCI
- 1.71
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Gut (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- HighWire Press Open Archive (submittedVersion)
- Newcastle University ePrints (Newcastle Univesity)
- Topics
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Health Sciences › Medicine › Hepatology › Liver Disease and Transplantation
- Health Sciences › Medicine › Epidemiology › Liver Disease Diagnosis and Treatment
- Keywords
- hepatic stellate cells, portal hypertension, hepatic microcirculation, stellate cell activation, liver fibrosis, vasoactive substances, chronic liver disease, therapeutic target
- MeSH terms
- Cell Communication, Humans, Hypertension, Portal, Liver Circulation, Microcirculation, Muscle Contraction, Muscle Relaxation, Muscle, Smooth, Vascular, Vasoconstrictor Agents, Hepatocytes
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