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Cited by 300

The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.

Promoter methylation of E-cadherin gene in gastric mucosa associated with Helicobacter pylori infection and in gastric cancer

Open access
Chan, A O-O, Lam, S-K, Wong, B C-Y, Wong, W-M, Yuen, M-F, Yeung, Y-H, Hui, W-M, Rashid, A, Kwong, Y-L·2003·Gut
DOI 10.1136/gut.52.4.502
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Abstract

Background: E-cadherin is an adhesion molecule involved in tumour invasion/metastasis. Silencing of E-cadherin by promoter CpG methylation has been shown in both familial and sporadic gastric cancers. Helicobacter pylori is a class I carcinogen in gastric cancer. Aims: This study was undertaken to investigate the association between methylation of E-cadherin and H pylori in gastric mucosa from dyspeptic patients, and in intestinal metaplasia and primary and metastatic adenocarcinoma from surgical specimens of patients with gastric cancer. Methods: E-cadherin methylation was studied using methylation specific polymerase chain reaction in microdissected tissue from biopsies or surgical resection specimens. E-cadherin expression was studied by immunohistochemistry. Results: E-cadherin methylation was present in 31% (11/35) of gastric mucosae from dyspeptic patients, and was associated with H pylori infection (p=0.002), but was independent of the age of the patient or presence or absence of gastritis. E-cadherin methylation was present in 0% (0/8) of normal mucosa, 57% (12/21) of intestinal metaplasias, and 58% (15/26) of primary and 65% (21/32) of metastatic cancers. E-cadherin methylation status was concordant in 92% (11/12) of intestinal metaplasias and primary cancers, and in 85% (17/20) of primary and metastatic cancers from the same resected specimen. E-cadherin methylation in gastric cancer was associated with depth of tumour invasion (p=0.02) and regional nodal metastasis (p=0.05). Conclusion: E-cadherin methylation is an early event in gastric carcinogenesis, and is initiated by H pylori infection.

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Metadata

Authors
Chan, A. O.-O., Lam, S.-K., Wong, B. C.-Y., Wong, W.-M., Yuen, M.-F., Yeung, Y.-H., Hui, W.-M., Rashid, A., & Kwong, Y.-L.
Venue
Gut
Publisher
BMJ
Published
2003-04
Volume
52
Issue
4
Pages
502-506
ISSN
  • 0017-5749 (ISSN-L)
  • 1468-3288
DOI
10.1136/gut.52.4.502
OpenAlex
W2134124314
Cited by
300
References
31
FWCI
4.72
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Promoter methylation of E-cadherin gene in gastric mucosa associated with Helicobacter pylori infection and in gastric cancer. https://app.cochat.ai/papers/10.1136/gut.52.4.502
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Chan, A. O.-O., Lam, S.-K., Wong, B. C.-Y., Wong, W.-M., Yuen, M.-F., Yeung, Y.-H., Hui, W.-M., Rashid, A., & Kwong, Y.-L. (2003). Promoter methylation of E-cadherin gene in gastric mucosa associated with Helicobacter pylori infection and in gastric cancer. Gut. https://doi.org/10.1136/gut.52.4.502

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.