The DOI matches its Crossref record; 88 of the 88 references it cites were found in a registry or an index.
Diagnosis and management of patients with reflux symptoms refractory to proton pump inhibitors
Abstract
Approximately a third of patients with suspected gastro-oesophageal reflux disease are resistant or partial responders to proton pump inhibitors (PPIs). Many of these patients do not have gastro-oesophageal reflux disease, but suffer from functional heartburn or dyspepsia. The potential mechanisms underlying failure of PPI treatment in patients with reflux-related symptoms include persistence of isolated or mixed acid, weakly acidic, bile or gas reflux, impaired oesophageal mucosal integrity, chemical or mechanical hypersensitivity to refluxates and psychological comorbidity. After thorough clinical evaluation and failure of empirical changes in PPI dose regime, diagnostic investigations include endoscopy and reflux monitoring with pH or pH-impedance monitoring. If symptoms are clearly related to persistent reflux, baclofen, antireflux surgery or pain modulators can be considered. If not, pain modulators are the only currently available therapy.
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Cites
The burden of selected digestive diseases in the United States
Sandler, R. S., Everhart, J. E., Donowitz, M., Adams, E., Cronin, K., Goodman, C., Gemmen, E., Shah, S., Avdic, A., & Rubin, R. (2002) · Gastroenterology · doi:10.1053/gast.2002.32978 · Cited by 1,512
Kaltenbach, T., Crockett, S., & Gerson, L. B. (2006) · Archives of Internal Medicine · doi:10.1001/archinte.166.9.965 · Cited by 621
Vela, M. F., Camacho-Lobato, L., Srinivasan, R., Tutuian, R., Katz, P. O., & Castell, D. O. (2001) · Gastroenterology · doi:10.1053/gast.2001.24840 · Cited by 613
Functional Esophageal Disorders
Galmiche, J. P., Clouse, R. E., Bálint, A., Cook, I. J., Kahrilas, P. J., Paterson, W. G., & Smout, A. J. P. M. (2006) · Gastroenterology · doi:10.1053/j.gastro.2005.08.060 · Cited by 602
Effectiveness of proton pump inhibitors in nonerosive reflux disease
Dean, B. B., Gano, A. D., Knight, K., Ofman, J. J., & Fass, R. (2004) · Clinical Gastroenterology and Hepatology · doi:10.1016/s1542-3565(04)00288-5 · Cited by 462
Tobey, N., Carson, J., Alkiek, R., & Orlando, R. (1996) · Gastroenterology · doi:10.1053/gast.1996.v111.pm8898633 · Cited by 462
Duodenogastroesophageal reflux: Relationship to pH and importance in Barrett's esophagus
Champion, G., Richter, J. E., Vaezi, M. F., Singh, S., & Alexander, R. (1994) · Gastroenterology · doi:10.1016/0016-5085(94)90123-6 · Cited by 455
Galmiche, J.-P., Hatlebakk, J., Attwood, S., Ell, C., Fiocca, R., Eklund, S., Långström, G., Lind, T., Lundell, L., & LOTUS Trial Collaborators, F. T. (2011) · JAMA · doi:10.1001/jama.2011.626 · Cited by 448
Zerbib, F., Roman, S., Ropert, A., des Varannes, S. B., Pouderoux, P., Chaput, U., Mion, F., Vérin, E., Galmiche, J.-P., & Sifrim, D. (2006) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2006.00711.x · Cited by 439
Self-citation
Cited by
Modern diagnosis of GERD: the Lyon Consensus
Gyawali, C. P., Kahrilas, P. J., Savarino, E., Zerbib, F., Mion, F., Smout, A. J. P. M., Vaezi, M., Sifrim, D., Fox, M. R., Vela, M. F., et al. (2018) · Gut · doi:10.1136/gutjnl-2017-314722 · Cited by 1,457
Self-citationManagement of Gastroesophageal Reflux Disease
Gyawali, C. P., & Fass, R. (2018) · Gastroenterology · doi:10.1053/j.gastro.2017.07.049 · Cited by 346
Metadata
- Authors
- Sifrim, D., & Zerbib, F.
- Venue
- Gut
- Publisher
- BMJ
- Published
- 2012-06-08
- Volume
- 61
- Issue
- 9
- Pages
- 1340-1354
- ISSN
- 0017-5749 (ISSN-L)
- 1468-3288
- OpenAlex
- W2159657819
- Cited by
- 346
- References
- 88
- FWCI
- 28.41
- Type
- journal article
- Language
- en
- Open access
- closed
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
