The DOI matches its Crossref record; 44 of the 44 references it cites were found in a registry or an index.
Bacterial genotoxin colibactin promotes colon tumour growth by inducing a senescence-associated secretory phenotype
Abstract
Background: Escherichia coli strains harbouring the pks island ( pks + E. coli ) are often seen in human colorectal tumours and have a carcinogenic effect independent of inflammation in an AOM/IL-10 −/− (azoxymethane/interleukin) mouse model. Objective: To investigate the mechanism sustaining pks + E. coli -induced carcinogenesis. Method: Underlying cell processes were investigated in vitro and in vivo (xenograft model) using intestinal epithelial cells infected by pks + E. coli or by an isogenic mutant defective for pks ( pks − E. coli ). The results were supported by data obtained from an AOM/DSS (azoxymethane/dextran sodium sulphate) colon cancer mouse model and from human colon cancer biopsy specimens colonised by pks + E. coli or pks− E. coli . Results: Colibactin-producing E. coli enhanced tumour growth in both xenograft and AOM/DSS models. Growth was sustained by cellular senescence (a direct consequence of small ubiquitin-like modifier (SUMO)-conjugated p53 accumulation), which was accompanied by the production of hepatocyte growth factor (HGF). The underlying mechanisms involve microRNA-20a-5p, which targets SENP1, a key protein regulating p53 deSUMOylation. These results are consistent with the expression of SENP1, microRNA-20a-5p, HGF and phosphorylation of HGF receptor found in human and mouse colon cancers colonised by pks + E. coli . Conclusion: These data reveal a new paradigm for carcinogenesis, in which colibactin-induced senescence has an important role.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“in several mouse models, other colibactin-producing E. coli have been observed to promote the development of colorectal cancer [125–131]”
From Selection, Comparative Genomics, and Potential Probiotic Features of Escherichia coli 5C, a pks-Negative Strain Isolated from Healthy Infant Donor Feces (2026) · cites this paper as [128]
Citations
Cites
Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008
Ferlay, J., Shin, H., Bray, F., Forman, D., Mathers, C. D., & Parkin, D. M. (2010) · International Journal of Cancer · doi:10.1002/ijc.25516 · Cited by 21,468
A genetic model for colorectal tumorigenesis
Fearon, E. R., & Vogelstein, B. (1990) · Cell · doi:10.1016/0092-8674(90)90186-i · Cited by 12,132
Stratton, M. R., Campbell, P. J., & Futreal, P. A. (2009) · Nature · doi:10.1038/nature07943 · Cited by 3,625
Global burden of cancers attributable to infections in 2008: a review and synthetic analysis
de Martel, C., Ferlay, J., Franceschi, S., Vignat, J., Bray, F., Forman, D., & Plummer, M. (2012) · The Lancet Oncology · doi:10.1016/s1470-2045(12)70137-7 · Cited by 2,540
IKKβ Links Inflammation and Tumorigenesis in a Mouse Model of Colitis-Associated Cancer
Greten, F. R., Eckmann, L., Greten, T. F., Park, J. M., Li, Z.-W., Egan, L. J., Kagnoff, M. F., & Karin, M. (2004) · Cell · doi:10.1016/j.cell.2004.07.013 · Cited by 2,433
c-Myc-regulated microRNAs modulate E2F1 expression
O'Donnell, K. A., Wentzel, E. A., Zeller, K. I., Dang, C. V., & Mendell, J. T. (2005) · Nature · doi:10.1038/nature03677 · Cited by 2,347
Intestinal inflammation targets cancer-inducing activity of the microbiota
Arthur, J. C., Perez-Chanona, E., Mühlbauer, M., Tomkovich, S., Uronis, J. M., Fan, T.-J., Campbell, B. J., Abujamel, T., Dogan, B., Rogers, A. B., et al. (2012) · Science · doi:10.1126/science.1224820 · Cited by 2,263
Cancer epigenomics: DNA methylomes and histone-modification maps
Esteller, M. (2007) · Nature Reviews Genetics · doi:10.1038/nrg2005 · Cited by 2,190
Four faces of cellular senescence
Rodier, F., & Campisi, J. (2011) · Journal of Cell Biology · doi:10.1083/jcb.201009094 · Cited by 2,070
Wu, S., Rhee, K.-J., Albesiano, E., Rabizadeh, S., Wu, X., Yen, H.-R., Huso, D. L., Brancati, F. L., Wick, E., McAllister, F., et al. (2009) · Nature Medicine · doi:10.1038/nm.2015 · Cited by 1,812
Cited by
Sorted by citations
Items 201–300 of 480
Epithelial cell plasticity: breaking boundaries and changing landscapes
Tata, A., Chow, R. D.-W., & Tata, P. R. (2021) · EMBO Reports · doi:10.15252/embr.202051921 · Cited by 32
Aja‐Macaya, P., Conde‐Pérez, K., Trigo‐Tasende, N., Buetas, E., Nasser‐Ali, M., Nión, P., Rumbo‐Feal, S., Ladra, S., Bou, G., Mira, Á., et al. (2025) · Scientific Reports · doi:10.1038/s41598-025-10999-8 · Cited by 35
The role of microbiomes in gastrointestinal cancers: new insights
Yarahmadi, A., & Afkhami, H. (2024) · Frontiers in Oncology · doi:10.3389/fonc.2023.1344328 · Cited by 30
The gut microbiota can orchestrate the signaling pathways in colorectal cancer
Bennedsen, A. L. B., Furbo, S., Bjarnsholt, T., Raskov, H., Gögenür, I., & Kvich, L. (2022) · Apmis · doi:10.1111/apm.13206 · Cited by 30
Mousa, J. J., Newsome, R. C., Yang, Y., Jobin, C., & Bruner, S. D. (2016) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2016.12.018 · Cited by 30
The Impact of the Gut Microbiome on Colorectal Cancer
Maisonneuve, C., Irrazábal, T., Martín, A., Girardin, S. E., & Philpott, D. J. (2017) · Annual Review of Cancer Biology · doi:10.1146/annurev-cancerbio-030617-050240 · Cited by 30
Microbial factors in inflammatory diseases and cancers
Ong, H. S., & Yim, H. C. H. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-981-10-5987-2_7 · Cited by 29
From dysbiosis to longevity: a narrative review into the gut microbiome’s impact on aging
Tseng, C., & Wu, C. (2025) · Journal of Biomedical Science · doi:10.1186/s12929-025-01179-x · Cited by 31
Boisseau, N., Barnich, N., & Koechlin‐Ramonatxo, C. (2022) · Nutrients · doi:10.3390/nu14050924 · Cited by 32
Xing, J., Liao, Y., Zhang, H., Zhang, W., Zhang, Z., Zhang, J., Wang, D., & Tang, D. (2022) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2022.804689 · Cited by 29
Microbiome in cancer: An exploration of carcinogenesis, immune responses and immunotherapy
Zhou, P., Hu, Y., Wang, X., Shen, L., Liao, X., Zhu, Y., Yu, J., Zhao, F., Zhou, Y., Shen, H., et al. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.877939 · Cited by 31
Microbiota Regulates Pancreatic Cancer Carcinogenesis through Altered Immune Response
Chai, Y., Huang, Z., Shen, X., Lin, T., Zhang, Y., Xu, F., Mao, Q., & Liang, Y. (2023) · Microorganisms · doi:10.3390/microorganisms11051240 · Cited by 29
Targeting colorectal cancer-associated bacteria: A new area of research for personalized treatments
Faïs, T., Delmas, J., Cougnoux, A., Dalmasso, G., & Bonnet, R. (2016) · Gut Microbes · doi:10.1080/19490976.2016.1155020 · Cited by 30
Self-citationVdovikova, S., Gilfillan, S., Wang, S., Dongre, M., Wai, S. N., & Hurtado, A. (2018) · Scientific Reports · doi:10.1038/s41598-018-25308-9 · Cited by 29
Suresh, A., Ranjan, A. K., Jadhav, S., Hussain, A., Shaik, S., Alam, M., Baddam, R., Wieler, L. H., & Ahmed, N. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.02631 · Cited by 30
The role of gut microbiota in intestinal and liver diseases
Hrncir, T., Hrncirova, L., Kverka, M., & Tlaskalová‐Hogenová, H. (2018) · Laboratory Animals · doi:10.1177/0023677218818605 · Cited by 29
Colonic adenoma-associated Escherichia coli express specific phenotypes
Ambrosi, C., Sarshar, M., Aprea, M. R., Pompilio, A., Bonaventura, G. D., Strati, F., Pronio, A., Nicoletti, M., Zagaglia, C., Palamara, A. T., et al. (2019) · Microbes and Infection · doi:10.1016/j.micinf.2019.02.001 · Cited by 30
Microbiome in Cancer Development and Treatment
Čierniková, S., Ševčíková, A., Mladosievičová, B., & Mego, M. (2023) · Microorganisms · doi:10.3390/microorganisms12010024 · Cited by 29
Escherichia coli: The Good, the Bad and the Ugly
Dalmasso, J. D. G. (2015) · Clinical Microbiology Open Access · doi:10.4172/2327-5073.1000195 · Cited by 28
Cellular Senescence, Inflammation, and Cancer in the Gastrointestinal Tract
Choi, E. L., Taheri, N., Chandra, A., & Hayashi, Y. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24129810 · Cited by 29
Relationship between Obesity, Gut Microbiome and Hepatocellular Carcinoma Development
Hara, E. (2015) · Digestive Diseases · doi:10.1159/000371679 · Cited by 30
Oncometabolites in cancer: from cancer cells to the tumor microenvironment
Chen, L., & Huang, M. (2024) · Holistic Integrative Oncology · doi:10.1007/s44178-024-00096-7 · Cited by 28
Iron at the crossroads of host–microbiome interactions in health and disease
Choi, G., & Bessman, N. J. (2025) · Nature Microbiology · doi:10.1038/s41564-025-02001-y · Cited by 28
Antibiotic Activity of Escherichia coli against Multiresistant Staphylococcus aureus
Faïs, T., Cougnoux, A., Dalmasso, G., Laurent, F. J., Delmas, J., & Bonnet, R. (2016) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00130-16 · Cited by 27
Self-citationBacterial cyclomodulins: types and roles in carcinogenesis
Morgan, R. N., Saleh, S. E., Farrag, H. A., & Aboulwafa, M. (2021) · Critical Reviews in Microbiology · doi:10.1080/1040841x.2021.1944052 · Cited by 27
Revealing a microbial carcinogen
Bleich, R. M., & Arthur, J. C. (2019) · Science · doi:10.1126/science.aaw5475 · Cited by 27
Current understandings of colibactin regulation
Addington, E., Sandalli, S., & Roe, A. J. (2024) · Microbiology · doi:10.1099/mic.0.001427 · Cited by 27
Commensal bacterial internalization by epithelial cells: An alternative portal for gut leakiness
Yu, L. C. (2015) · Tissue Barriers · doi:10.1080/21688370.2015.1008895 · Cited by 26
Liu, Y., Chen, L., Zhi, C., Shen, M., Sun, W., Miao, D., & Yuan, X. (2016) · PLoS ONE · doi:10.1371/journal.pone.0146426 · Cited by 26
Li, S., Fu, C., Zhao, Y., & He, J. (2019) · BioMed Research International · doi:10.1155/2019/8020785 · Cited by 27
Harnack, C., Berger, H., Liu, L., Mollenkopf, H., Strowig, T., & Sigal, M. J. (2023) · Gut Microbes · doi:10.1080/19490976.2023.2233689 · Cited by 28
Sahu, U., Choudhury, A., Parvez, S., Biswas, S., & Kar, S. (2017) · Cell Death and Disease · doi:10.1038/cddis.2017.27 · Cited by 26
Distinctive tumorigenic significance and innovative oncology targets of SUMOylation
Zhou, H., Deng, N., Li, Y., Hu, X., Xue, Y., Jia, S., Zheng, C., Gao, S., Wu, H., & Li, K. (2024) · Theranostics · doi:10.7150/thno.97162 · Cited by 25
Suraweera, N., Mouradov, D., Li, S., Jorissen, R. N., Hampson, D., Ghosh, A., Sengupta, N., Thaha, M. A., Ahmed, S., Kirwan, M., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.9015 · Cited by 25
Dubbert, S., Klinkert, B., Schimiczek, M., Wassenaar, T. M., & Bünau, R. V. (2020) · European Journal of Microbiology and Immunology · doi:10.1556/1886.2019.00025 · Cited by 24
Microbiome in drug resistance to colon cancer
Pandey, K. R., & Umar, S. (2021) · Current Opinion in Physiology · doi:10.1016/j.cophys.2021.100472 · Cited by 24
Relationships between gut microbiota, red meat consumption and colorectal cancer.
Diakité, M., Diakité, B., Koné, A., Balam, S., Fofana, D., Diallo, D., Kassogué, Y., Traoré, C. B., Kamaté, B., Ba, D. M., et al. (2022) · PubMed · Cited by 34
Induction and modulation of genotoxicity by the bacteriome in mammals
Druzhinin, V. G., Matskova, L. V., & Fucic, A. (2018) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2018.04.002 · Cited by 24
Wang, Z., Liang, L., Liu, L., Wang, Z., Wang, Y., Yu, Z., Wu, B., & Chen, Y. (2023) · Microbiology Spectrum · doi:10.1128/spectrum.02819-22 · Cited by 23
A tale of two bacteria – Bacteroides fragilis, Escherichia coli, and colorectal cancer
Lichtenstern, C. R., & Lamichhane-Khadka, R. (2023) · Frontiers in Bacteriology · doi:10.3389/fbrio.2023.1229077 · Cited by 23
Zhang, G., & Sun, D. (2024) · Frontiers in Microbiology · doi:10.3389/fmicb.2024.1501973 · Cited by 23
Ancient Thali Diet: Gut Microbiota, Immunity, and Health.
Shondelmyer, K., Knight, R. D., Sanivarapu, A., Ogino, S., & Vanamala, J. K. P. (2018) · Europe PMC (PubMed Central) · Cited by 23
Toumazi, D., & Constantinou, C. (2020) · Oncology · doi:10.1159/000507959 · Cited by 23
Microbial carcinogenic toxins and dietary anti-cancer protectants
Stone, T. W., & Darlington, L. G. (2017) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-017-2487-z · Cited by 23
Dangtakot, R., Intuyod, K., Ahooja, A., Wongwiwatchai, J., Hanpanich, P., Lulitanond, A., Chamgramol, Y., Pinlaor, S., & Pinlaor, P. (2021) · Asian Pacific Journal of Cancer Prevention · doi:10.31557/apjcp.2021.22.1.233 · Cited by 23
Dietary Modulation of Bacteriophages as an Additional Player in Inflammation and Cancer
Marongiu, L., Burkard, M., Venturelli, S., & Allgayer, H. (2021) · Cancers · doi:10.3390/cancers13092036 · Cited by 23
The crosstalk of the human microbiome in breast and colon cancer: A metabolomics analysis
Mukherjee, A. G., Wanjari, U. R., Bradu, P., Murali, R., Kannampuzha, S., Loganathan, T., Doss, C. G. P., Arun Prakash, B. P., Renu, K., Dey, A., et al. (2022) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2022.103757 · Cited by 22
Cytotoxic Escherichia coli strains encoding colibactin colonize laboratory mice
García, A., Mannion, A. J., Feng, Y., Madden, C. M., Bakthavatchalu, V., Shen, Z., Ge, Z., & Fox, J. G. (2016) · Microbes and Infection · doi:10.1016/j.micinf.2016.07.005 · Cited by 22
Gut microbes in gastrointestinal cancers
Wang, F., Song, M., Lu, X., Zhu, X., & Deng, J. (2021) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2021.03.037 · Cited by 21
Leveraging Microbial Genomes and Genomic Context for Chemical Discovery
Kountz, D. J., & Balskus, E. P. (2021) · Accounts of Chemical Research · doi:10.1021/acs.accounts.1c00100 · Cited by 21
Lv, W., Song, J., Raka, R. N., Sun, J., Shi, G., Wu, H., Xiao, J., & Xu, D. (2023) · Food Research International · doi:10.1016/j.foodres.2023.113302 · Cited by 21
Sumoylation as an Integral Mechanism in Bacterial Infection and Disease Progression
Srikanth, C. V., & Verma, S. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-50044-7_22 · Cited by 22
Adherent-invasive Escherichia coli in Crohn’s disease: the 25th anniversary
Barnich, N., Arthur, J. C., Buisson, A., Campbell, B. J., Carbonnel, F., Chassaing, B., Coombes, B. K., Denizot, J., Dogan, B., Faith, J. J., et al. (2025) · Gut · doi:10.1136/gutjnl-2025-335331 · Cited by 21
Prevalence and implications of pKs-positive Escherichia coli in colorectal cancer
de Souza, J. B., Campos, L. A. D. A., Palácio, S. B., de Castro, M. C. A. B., & Cavalcanti, I. M. F. (2024) · Life Sciences · doi:10.1016/j.lfs.2024.122462 · Cited by 20
Biological and Clinical Characteristics of Proximal Colon Cancer: Far from Its Anatomical Subsite
Yang, Q. Z., Qu, R., Lu, S., Zhang, Y., Zhang, Z., & Fu, W. (2024) · International Journal of Medical Sciences · doi:10.7150/ijms.97574 · Cited by 20
Zechner, E. L., & Kienesberger, S. (2024) · Gut Microbes · doi:10.1080/19490976.2024.2430423 · Cited by 20
Mycobacterium tuberculosis exploits host ATM kinase for survival advantage through SecA2 secretome
Lochab, S., Singh, Y. P., Sengupta, S., & Nandicoori, V. K. (2020) · eLife · doi:10.7554/elife.51466 · Cited by 21
Suresh, A., Shaik, S., Baddam, R., Ranjan, A. K., Qumar, S., Jadhav, S., Semmler, T., Ghazi, I. A., Wieler, L. H., & Ahmed, N. (2021) · mBio · doi:10.1128/mbio.03634-20 · Cited by 22
The Emerging Roles of Human Gut Microbiota in Gastrointestinal Cancer
Guo, Q., Qin, H., Liu, X., Zhang, X., Chen, Z., Qin, T., Chang, L., & Zhang, W. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.915047 · Cited by 21
Clostridioides difficile Toxin B Induced Senescence: A New Pathologic Player for Colorectal Cancer?
Fettucciari, K., Fruganti, A., Stracci, F., Spaterna, A., Marconi, P., & Bassotti, G. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24098155 · Cited by 19
Cellular senescence in vivo: From cells to tissues to pathologies
Kumar, A., Bano, D., & Ehninger, D. (2020) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2020.111308 · Cited by 19
Wang, X., Undi, R. B., Ali, N., & Huycke, M. M. (2021) · Disease Models & Mechanisms · doi:10.1242/dmm.048793 · Cited by 20
François, R. M. M., Massicard, J.-M., & Weissman, K. J. (2024) · Natural Product Reports · doi:10.1039/d4np00046c · Cited by 18
Mirzarazi, M., Bashiri, S., Hashemi, A., Vahidi, M., Kazemi, B., & Bandehpour, M. (2022) · BMC Microbiology · doi:10.1186/s12866-022-02540-y · Cited by 18
Gong, D., Adomako-Bonsu, A. G., Wang, M., & Li, J. (2023) · PeerJ · doi:10.7717/peerj.15777 · Cited by 20
SUMOylation at the crossroads of gut health: insights into physiology and pathology
Ma, X., Li, M., Qi, G.-Q., Wei, L., & Zhang, D. (2024) · Cell Communication and Signaling · doi:10.1186/s12964-024-01786-5 · Cited by 18
Vigneswaran, J., & Shogan, B. D. (2020) · Journal of Gastrointestinal Surgery · doi:10.1007/s11605-020-04694-4 · Cited by 20
The specificity and structure of DNA cross-linking by the gut bacterial genotoxin colibactin
Carlson, E. S., Haslecker, R., Lecchi, C., Ramos, M. A. A., Vennelakanti, V., Honaker, L., Stornetta, A., Millán, E. S., Johnson, B. A., Kulik, H. J., et al. (2025) · Science · doi:10.1126/science.ady3571 · Cited by 18
Dietary Patterns and Associated Microbiome Changes that Promote Oncogenesis
Ibragimova, S., Ramachandran, R., Ali, F. R., Lipovich, L., & Ho, S. B. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.725821 · Cited by 18
Gaab, M. E., Lozano, P. O., Ibañez, D., Manese, K. D., Riego, F. M., Tiongco, R. E., & Albano, P. M. (2022) · Laboratory Medicine · doi:10.1093/labmed/lmac072 · Cited by 18
Escherichia coli and HPV16 coinfection may contribute to the development of cervical cancer
Zou, Q., Wu, Y., Zhang, S., Li, S., Li, S., Su, Y., Zhang, L., Li, Q., Zou, H., Zhang, X., et al. (2024) · Virulence · doi:10.1080/21505594.2024.2319962 · Cited by 17
Host–microbe interactions and spatial variation of cancer in the gut
Shanahan, F., & O’Toole, P. W. (2014) · Nature reviews. Cancer · doi:10.1038/nrc3765 · Cited by 17
Certaines bactéries de la flore commensale exacerberaient-elles la carcinogenèse colorectale ?
Raisch, J., Dalmasso, G., Bonnet, R., Barnich, N., Bonnet, M., & Bringer, M.-A. (2016) · médecine/sciences · doi:10.1051/medsci/20163202011 · Cited by 17
Self-citationVolpe, M. R., Wilson, M. R., Brotherton, C. A., Winter, E. S., Johnson, S. E., & Balskus, E. P. (2019) · ACS Chemical Biology · doi:10.1021/acschembio.9b00069 · Cited by 19
King, S. J., & McCole, D. F. (2019) · Intestinal Research · doi:10.5217/ir.2018.00170 · Cited by 18
Williams, P. C., Wernke, K. M., Tirla, A., & Herzon, S. B. (2020) · Natural Product Reports · doi:10.1039/d0np00072h · Cited by 18
Evolution of Polymyxin Resistance Regulates Colibactin Production in Escherichia coli
Sadecki, P. W., Balboa, S. J., Lopez, L. R., Kedziora, K. M., Arthur, J. C., & Hicks, L. M. (2021) · ACS Chemical Biology · doi:10.1021/acschembio.1c00322 · Cited by 19
Pratt, M., Forbes, J. D., Knox, N., Domselaar, G. V., & Bernstein, C. N. (2022) · Gastroenterology · doi:10.1053/j.gastro.2021.12.287 · Cited by 19
CTRP4: a new member of the adipocytokine family
Wang, L. (2017) · Cellular and Molecular Immunology · doi:10.1038/cmi.2017.83 · Cited by 16
Microbiota and cancer: In vitro and in vivo models to evaluate nanomedicines
Ladaycia, A., Loretz, B., Passirani, C., Lehr, C., & Lepeltier, É. (2020) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2020.12.015 · Cited by 17
Tang-Fichaux, M., Branchu, P., Nougayrède, J., & Oswald, É. (2021) · Toxins · doi:10.3390/toxins13120897 · Cited by 18
Chat, H., Dalmasso, G., Godfraind, C., Bonnin, V., Beyrouthy, R., Bonnet, M., Barnich, N., Mettouchi, A., Lemichez, E., Bonnet, R., et al. (2023) · Gut Microbes · doi:10.1080/19490976.2023.2229569 · Cited by 16
Self-citationJi, G., Zhao, J., Si, X., & Song, W. (2024) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2024.115345 · Cited by 16
Laborda-Illanes, A., Aranega-Martín, L., Sánchez‐Alcoholado, L., Boutriq, S., Plaza-Andrades, I. J., Peralta-Linero, J., Ruiz, G. G., Pajares, B., Álvarez, M., Alba, E., et al. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25137091 · Cited by 15
Kurnick, S. A., Mannion, A. J., Feng, Y., Madden, C. M., Chamberlain, P., & Fox, J. G. (2019) · Comparative Medicine · doi:10.30802/aalas-cm-18-000099 · Cited by 15
Nutrition and Microbiome Interactions in Human Cancer
Daschner, P. J., Ross, S., Seifried, H. E., Kumar, A., & Flores, R. (2022) · Journal of the Academy of Nutrition and Dietetics · doi:10.1016/j.jand.2022.10.004 · Cited by 15
Molan, K., Podlesek, Z., Hodnik, V., Butala, M., Oswald, É., & Bertok, D. Ž. (2019) · DNA repair · doi:10.1016/j.dnarep.2019.05.003 · Cited by 14
Gut Microbiota in Colorectal Cancer: Associations, Mechanisms, and Clinical Approaches
Pleguezuelos‐Manzano, C., Puschhof, J., & Clevers, H. C. (2021) · Annual Review of Cancer Biology · doi:10.1146/annurev-cancerbio-070120-095211 · Cited by 15
Typhoid toxin hijacks Wnt5a to establish host senescence and Salmonella infection
ElGhazaly, M., Collins, M. O., Ibler, A. E., & Humphreys, D. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.113181 · Cited by 13
Lv, C., Abdullah, M., Su, C., Chen, W., Zhou, N., Cheng, Z., Chen, Y., Li, M., Simpson, K. W., Elsaadi, A. M., et al. (2025) · BMC Genomics · doi:10.1186/s12864-024-11198-x · Cited by 13
Bacterial Toxins Are a Never-Ending Source of Surprises: From Natural Born Killers to Negotiators
Chiloeches, M. L., Bergonzini, A., & Frisan, T. (2021) · Toxins · doi:10.3390/toxins13060426 · Cited by 14
The Role of Escherichia coli in the Development and Progression of Cancer
(2017) · ARC Journal of Cancer Science · doi:10.20431/2455-6009.0301001 · Cited by 13
Replication Study: Intestinal inflammation targets cancer-inducing activity of the microbiota
Eaton, K. A., Pirani, A. M., Snitkin, E. S., Reproducibility Project: Cancer Biology, Iorns, E. J., Tsui, R., Denis, A., Perfito, N., Errington, T. M., Iorns, E. J., et al. (2018) · eLife · doi:10.7554/elife.34364 · Cited by 13
Abahussin, H. M., Alotaibi, M. S., Alhazzaa, O. A., Alotaibi, A. G., Alsaab, S. M., Aljawini, N., & Alawad, A. O. (2025) · Gut Pathogens · doi:10.1186/s13099-025-00788-z · Cited by 12
Taoum, C., Carrier, G., Jarlier, M., Roche, G., Gagnière, J., Fiess, C., de Forges, H., Chevarin, C., Colombo, P., Barnich, N., et al. (2022) · BMJ Open · doi:10.1136/bmjopen-2022-061527 · Cited by 12
Self-citationLiu, S., Zhou, W., Deng, X., Jiang, W., Wang, Y., Zhan, J., & Hu, B. (2023) · Frontiers in Nutrition · doi:10.3389/fnut.2023.1231485 · Cited by 12
Identification of Gut Microbiota Profile Associated with Colorectal Cancer in Saudi Population
Alhhazmi, A. A., Almutawif, Y. A., Mumena, W. A., Alhazmi, S. M., Abujamel, T. S., Alhusayni, R. M., Aloufi, R. M., Alhejaili, R. A., Alhujaily, R., Alrehaili, L. M., et al. (2023) · Cancers · doi:10.3390/cancers15205019 · Cited by 12
Leite-Gomes, E., Dias, A. M., Azevedo, C. M., Santos‐Pereira, B., Magalhães, M., Garrido, M., Amorim, R., Lago, P. M., Marcos‐Pinto, R., & Pinho, S. S. (2021) · Inflammatory Bowel Diseases · doi:10.1093/ibd/izab291 · Cited by 13
Pandey, M., & Bhattacharyya, J. (2024) · Epigenomics · doi:10.2217/epi-2023-0382 · Cited by 13
When our genome is targeted by pathogenic bacteria
Lemercier, C. (2015) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-015-1900-8 · Cited by 12
Metadata
- Authors
- Cougnoux, A., Dalmasso, G., Martinez, R., Buc, E., Delmas, J., Gibold, L., Sauvanet, P., Darcha, C., Déchelotte, P., Bonnet, M., Pezet, D., Wodrich, H., Darfeuille-Michaud, A., & Bonnet, R.
- Affiliations
- Inserm (FR)
- Centre National de la Recherche Scientifique (FR)
- Centre Hospitalier Universitaire de Clermont-Ferrand (FR)
- Clermont Université, UMR 1071 Inserm/Université d'Auvergne, Clermont-Ferrand, France
- Corresponding author
- Bonnet, Richard
- ORCID
- Venue
- Gut
- Publisher
- BMJ
- Published
- 2014-03-21
- Volume
- 63
- Issue
- 12
- Pages
- 1932-1942
- ISSN
- 0017-5749 (ISSN-L)
- 1468-3288
- OpenAlex
- W2111725588
- Semantic Scholar
- 15f9aae86af823cd6aad2d6681907d71cc828598
- Cited by
- 486
- References
- 44
- Citations by year
- 2026: 34 · 2025: 35 · 2024: 43 · 2023: 46 · 2022: 54 · 2021: 68 · 2020: 50 · 2019: 37 · 2018: 35 · 2017: 27 · 2016: 25 · 2015: 22 · 2014: 10
- FWCI
- 19.73
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Gut (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- HighWire Press Open Archive (submittedVersion)
- Funders
- Institut National de la Santé et de la Recherche Médicale
- Ligue Contre le Cancer
- Institut National de la Recherche Agronomique
- Centre Hospitalier Universitaire de Clermont-Ferrand
- Topics
- Life Sciences › Immunology and Microbiology › Microbiology › Escherichia coli research studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biotechnology › Bacterial Cancer Therapy
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Keywords
- colibactin, Escherichia coli, pks island, colorectal cancer, tumor growth, cellular senescence, senescence-associated secretory phenotype, hepatocyte growth factor, SENP1, SUMOylation, bacterial carcinogenesis, AOM/DSS model, xenograft models
- MeSH terms
- Animals, Colonic Neoplasms, Cysteine Endopeptidases, Escherichia coli, Humans, Mutagens, Mutation, Neoplasms, Experimental, Nuclear Proteins, Endopeptidases, Peptides, Cellular Senescence, Hepatocyte Growth Factor, Proto-Oncogene Proteins c-met, Mice, Polyketides, Carcinogenesis
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review