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Cited by 88Pancreatitis Pathology and TreatmentGenetic Associations and EpidemiologyBlood groups and transfusion

The DOI matches its Crossref record; 44 of the 44 references it cites were found in a registry or an index.

Fucosyltransferase 2 (FUT2) non-secretor status and blood group B are associated with elevated serum lipase activity in asymptomatic subjects, and an increased risk for chronic pancreatitis: a genetic association study

Weiss, Frank Ulrich, Schurmann, Claudia, Guenther, Annett, Ernst, Florian, Teumer, Alexander, Mayerle, Julia, Simon, Peter, Völzke, Henry, Radke, Dörte, Greinacher, Andreas, Kuehn, Jens-Peter, Zenker, Martin, Völker, Uwe, Homuth, Georg, Lerch, Markus M·2015·Gut
DOI 10.1136/gutjnl-2014-306930
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Abstract

OBJECTIVE: Serum lipase activities above the threefold upper reference limit indicate acute pancreatitis. We investigated whether high lipase activity-within the reference range and in the absence of pancreatitis-are associated with genetic single nucleotide polymorphisms (SNP), and whether these identified SNPs are also associated with clinical pancreatitis. METHODS: Genome-wide association studies (GWAS) on phenotypes 'serum lipase activity' and 'high serum lipase activity' were conducted including 3966 German volunteers from the population-based Study-of-Health-in-Pomerania (SHIP). Lead SNPs associated on a genome-wide significance level were replicated in two cohorts, 1444 blood donors and 1042 pancreatitis patients. RESULTS: Initial discovery GWAS detected SNPs within or near genes encoding the ABO blood group specifying transferases A/B (ABO), Fucosyltransferase-2 (FUT2), and Chymotrypsinogen-B2 (CTRB2), to be significantly associated with lipase activity levels in asymptomatic subjects. Replication analyses in blood donors confirmed the association of FUT-2 non-secretor status (OR=1.49; p=0.012) and ABO blood-type-B (OR=2.48; p=7.29×10(-8)) with high lipase activity levels. In pancreatitis patients, significant associations were found for FUT-2 non-secretor status (OR=1.53; p=8.56×10(-4)) and ABO-B (OR=1.69, p=1.0×10(-4)) with chronic pancreatitis, but not with acute pancreatitis. Conversely, carriers of blood group O were less frequently affected by chronic pancreatitis (OR=0.62; p=1.22×10(-05)) and less likely to have high lipase activity levels (OR=0.59; p=8.14×10(-05)). CONCLUSIONS: These are the first results indicating that ABO blood type-B as well as FUT2 non-secretor status are common population-wide risk factors for developing chronic pancreatitis. They also imply that, even within the reference range, elevated lipase activities may indicate subclinical pancreatic injury in asymptomatic subjects.

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Metadata

Authors
Weiss, F. U., Schurmann, C., Guenther, A., Ernst, F., Teumer, A., Mayerle, J., Simon, P., Völzke, H., Radke, D., Greinacher, A., Kuehn, J.-P., Zenker, M., Völker, U., Homuth, G., & Lerch, M. M.
Affiliations
  • Universitätsmedizin Greifswald (DE)
  • University Hospital Magdeburg (DE)
Corresponding author
Lerch, Markus M
ORCID
Venue
Gut
Publisher
BMJ
Published
2014-07-15
Volume
64
Issue
4
Pages
646-656
ISSN
  • 0017-5749 (ISSN-L)
  • 1468-3288
DOI
10.1136/gutjnl-2014-306930
OpenAlex
W2143278956
Cited by
88
References
44
Citations by year
2026: 2 · 2025: 4 · 2024: 6 · 2023: 9 · 2022: 7 · 2021: 4 · 2020: 8 · 2019: 10 · 2018: 9 · 2017: 10 · 2016: 10 · 2015: 8 · 2014: 1
FWCI
10.23
Type
journal article
Language
en
Open access
closed
Locations
  • Gut (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Surgery › Pancreatitis Pathology and Treatment
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
  • Health Sciences › Medicine › Hematology › Blood groups and transfusion
Keywords
ABO blood group system, blood group B, serum lipase activity, chronic pancreatitis, acute pancreatitis, genetic susceptibility, single nucleotide polymorphisms
MeSH terms
ABO Blood-Group System, Galactoside 2-alpha-L-fucosyltransferase, Adult, Aged, Aged, 80 and over, Female, Fucosyltransferases, Humans, Lipase, Male, Middle Aged, Risk Assessment, Polymorphism, Single Nucleotide, Pancreatitis, Chronic, Genome-Wide Association Study, Young Adult, Genetic Association Studies

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