The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.
Maintenance of sinus rhythm with an ablation strategy in patients with atrial fibrillation is associated with a lower risk of stroke and death
Abstract
OBJECTIVE: To investigate whether catheter ablation of atrial fibrillation (AF) reduces stroke rate or mortality. METHODS: An international multicentre registry was compiled from seven centres in the U.K. and Australia for consecutive patients undergoing catheter ablation of AF. Long-term outcomes were compared with (1) a cohort with AF treated medically in the Euro Heart Survey, and (2) a hypothetical cohort without AF, age and gender matched to the general population. Analysis of stroke and death was carried out after the first procedure (including peri-procedural events) regardless of success, on an intention-to-treat basis. RESULTS: 1273 patients, aged 58±11 years, 56% paroxysmal AF, CHADS(2) score 0.7±0.9, underwent 1.8±0.9 procedures. Major complications occurred in 5.4% of procedures, including stroke/TIA in 0.7%. Freedom from AF following the last procedure was 85% (76% off antiarrhythmic drugs) for paroxysmal AF, and 72% (60% off antiarrhythmic drugs) for persistent AF. During 3.1 (1.0-9.6) years from the first procedure, freedom from AF predicted stroke-free survival on multivariate analysis (HR=0.30, CI 0.16 to 0.55, p<0.001). Rates of stroke and death were significantly lower in this cohort (both 0.5% per patient-year) compared with those treated medically in the Euro Heart Survey (2.8% and 5.3%, respectively; p<0.0001). Rates of stroke and death were no different from those of the general population (0.4% and 1.0%, respectively). CONCLUSION: Restoration of sinus rhythm by catheter ablation of AF is associated with lower rates of stroke and death compared with patients treated medically.
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“Although observational studies suggest a relatively low stroke rate in the first few years after catheter ablation of AF, 737,[771][772][773][774][775][776]”
From 2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS (2016) · cites this paper as [737]
Citations
Cites
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A comparison of rate control and rhythm control in patients with atrial fibrillation
(2002) · New England Journal of Medicine · doi:10.1056/nejmoa021328 · Cited by 4,405
Mortality and Morbidity in Patients Receiving Encainide, Flecainide, or Placebo
Echt, D. S., Liebson, P. R., Mitchell, L. B., Peters, R. W., Obias-Manno, D., Barker, A. H., Arensberg, D., Baker, A., Friedman, L., Greene, H. L., et al. (1991) · New England Journal of Medicine · doi:10.1056/nejm199103213241201 · Cited by 3,244
Epidemiologic Features of Chronic Atrial Fibrillation
Kannel, W. B., Abbott, R. D., Savage, D. D., & McNamara, P. M. (1982) · New England Journal of Medicine · doi:10.1056/nejm198204293061703 · Cited by 2,304
Calkins, H. G., Brugada, J., Packer, D. L., Cappato, R., Chen, S., Crijns, H. J. G. M., Damiano, R. J., Davies, D. W., Haines, D. E., Haı̈ssaguerre, M., et al. (2007) · Heart Rhythm · doi:10.1016/j.hrthm.2007.04.005 · Cited by 1,690
Rhythm control versus rate control for atrial fibrillation and heart failure
Roy, D., Talajic, M., Nattel, S., Wyse, D. G., Dorian, P., Lee, K. L., Bourassa, M. G., Arnold, J. M. O., Buxton, A. E., Camm, A. J., et al. (2008) · New England Journal of Medicine · doi:10.1056/nejmoa0708789 · Cited by 1,585
Waldo, A. L., Camm, A. J., deRuyter, H., Friedman, P. L., MacNeil, D. J., Pauls, J. F., Pitt, B., Pratt, C. M., Schwartz, P. J., & Veltri, E. P. (1996) · The Lancet · doi:10.1016/s0140-6736(96)02149-6 · Cited by 1,373
Calkins, H. G., Brugada, J., Packer, D. L., Cappato, R., Chen, S.-A., Crijns, H. J. G. M., Damiano, R. J., Davies, D. W., Haines, D. E., Haïssaguerre, M., et al. (2007) · EP Europace · doi:10.1093/europace/eum120 · Cited by 1,289
The AFFIRM Investigators (2004) · Circulation · doi:10.1161/01.cir.0000121736.16643.11 · Cited by 1,202
Research works printed but not linked: 1
- Bunch, 2006, Mortality benefit and quality of life outcomes in patients undergoing curative ablation for atrial fibrillation: comparison with a disease-matched community population, Circulation, 114, 602
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2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS
Kirchhof, P. F., Benussi, S., Kotecha, D., Ahlsson, A., Atar, D., Casadei, B., Castellà, M., Diener, H., Heidbüchel, H., Hendriks, J., et al. (2016) · EP Europace · doi:10.1093/europace/euw295 · Cited by 6,438
2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS
Kirchhof, P., Benussi, S., Kotecha, D., Ahlsson, A., Atar, D., Casadei, B., Castella, M., Diener, H.-C., Heidbuchel, H., Hendriks, J., et al. (2016) · European Heart Journal · doi:10.1093/eurheartj/ehw210 · Cited by 6,418
Calkins, H. G., Hindricks, G., Cappato, R., Kim, Y., Saad, E., Aguinaga, L., Akar, J. G., Badhwar, V., Brugada, J., Camm, A. J., et al. (2017) · Heart Rhythm · doi:10.1016/j.hrthm.2017.05.012 · Cited by 2,794
2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS
Kirchhof, P., Benussi, S., Kotecha, D., Ahlsson, A., Atar, D., Casadei, B., Castella, M., Diener, H.-C., Heidbuchel, H., Hendriks, J., et al. (2016) · European Journal of Cardio-Thoracic Surgery · doi:10.1093/ejcts/ezw313 · Cited by 1,403
Calkins, H. G., Hindricks, G., Cappato, R., Kim, Y., Saad, E., Aguinaga, L., Akar, J. G., Badhwar, V., Brugada, J., Camm, A. J., et al. (2017) · EP Europace · doi:10.1093/europace/eux274 · Cited by 1,203
Metadata
- Authors
- Hunter, R. J., McCready, J., Diab, I., Page, S. P., Finlay, M., Richmond, L., French, A., Earley, M. J., Sporton, S., Jones, M., Joseph, J. P., Bashir, Y., Betts, T. R., Thomas, G., Staniforth, A., Lee, G., Kistler, P., Rajappan, K., Chow, A., & Schilling, R. J.
- Affiliations
- St Bartholomew's Hospital (GB)
- University College Hospital at Westmoreland Street (GB)
- Barts Health NHS Trust (GB)
- John Radcliffe Hospital (GB)
- Nottingham University Hospitals NHS Trust (GB)
- Baker Heart and Diabetes Institute (AU)
- Corresponding author
- Schilling, Richard J
- ORCID
- Venue
- Heart
- Publisher
- BMJ
- Published
- 2011-09-19
- Volume
- 98
- Issue
- 1
- Pages
- 48-53
- ISSN
- 1355-6037 (ISSN-L)
- 1468-201X
- OpenAlex
- W2053064155
- Cited by
- 183
- References
- 28
- Citations by year
- 2026: 5 · 2025: 2 · 2024: 5 · 2023: 7 · 2022: 5 · 2021: 7 · 2020: 10 · 2019: 13 · 2018: 11 · 2017: 17 · 2016: 12 · 2015: 14 · 2014: 37 · 2013: 24 · 2012: 11
- FWCI
- 16.00
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Heart (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Funders
- British Heart Foundation (PG/08/130)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Atrial Fibrillation Management and Outcomes
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Arrhythmias and Treatments
- Health Sciences › Medicine › Clinical Neurology › Acute Ischemic Stroke Management
- Keywords
- atrial fibrillation, catheter ablation, sinus rhythm restoration, stroke prevention, mortality, antiarrhythmic drugs, paroxysmal atrial fibrillation, persistent atrial fibrillation, CHADS2 score, long-term outcomes
- MeSH terms
- Administration, Oral, Aged, Anticoagulants, Atrial Fibrillation, Female, Hemorrhage, Humans, Male, Middle Aged, Risk Factors, Case-Control Studies, Treatment Outcome, Catheter Ablation, Stroke, Kaplan-Meier Estimate
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