Biochemical and functional abnormalities of left and right ventricular function after ultra-endurance exercise
Abstract
Background There is evidence that ultra-endurance exercise causes myocardial injury. The extent and duration of these changes remains unresolved. Recent reports have speculated that structural adaptations to exercise, particularly of the right ventricle, may predispose to tachyarrhythmias and sudden cardiac death. Objective To quantify the extent and duration of post-exercise cardiac injury with particular attention to right ventricular (RV) dysfunction. Methods 27 athletes (20 male, 7 female) were tested 1 week before, immediately after and 1 week after an ultra-endurance triathlon. Tests included cardiac troponin I (cTnI), B-type natriuretic peptide (BNP) and comprehensive echocardiographic assessment. Results 26 athletes completed the race and testing procedures. Post-race, cTnI was raised in 15 athletes (58%) and the mean value for the entire cohort increased (0.17 vs 0.49 microg/l, p Conclusion Myocardial damage occurs during intense ultra-endurance exercise and, in particular, there is a significant reduction in RV function. Almost all abnormalities resolve within 1 week.
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Right ventricular function may be more profoundly affected by intense endurance exercise than left ventricular function.
“However, right ventricular (RV) function may be more profoundly affected by intense endurance exercise 6 -10”
From Exercise-induced right ventricular dysfunction and structural remodelling in endurance athletes (2012) · cites this paper as [6]
In some cases, right ventricular recovery may be incomplete.
“and, in some cases, RV recovery may be incomplete.6,11”
From Exercise-induced right ventricular dysfunction and structural remodelling in endurance athletes (2012) · cites this paper as [6]
Cites
Lang, R. M., Bierig, M., Devereux, R. B., Flachskampf, F. A., Foster, E., Pellikka, P. A., Picard, M. H., Roman, M. J., Seward, J., Shanewise, J. S., et al. (2005) · Journal of the American Society of Echocardiography · doi:10.1016/j.echo.2005.10.005 · Cited by 11,318 · see citing works
Heidbüchel, H. (2003) · European Heart Journal · doi:10.1016/s0195-668x(03)00282-3 · Cited by 395 · see citing works
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Exercise-induced right ventricular dysfunction and structural remodelling in endurance athletes
La Gerche, A., Burns, A. T., Mooney, D. J., Inder, W. J., Taylor, A. J., Bogaert, J., MacIsaac, A. I., Heidbüchel, H., & Prior, D. L. (2012) · European Heart Journal · doi:10.1093/eurheartj/ehr397 · Cited by 776 · see citing works
Self-citationDisproportionate exercise load and remodeling of the athlete's right ventricle
LA GERCHE, A., HEIDBÜCHEL, H., BURNS, A. T., MOONEY, D. J., TAYLOR, A. J., PFLUGER, H. B., INDER, W. J., MACISAAC, A. I., & PRIOR, D. L. (2011) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e31820607a3 · Cited by 347 · see citing works
Self-citationThe effects of endurance exercise on the heart: panacea or poison?
Parry-Williams, G., & Sharma, S. (2020) · Nature Reviews Cardiology · doi:10.1038/s41569-020-0354-3 · Cited by 102 · see citing works
La Gerche, A., Inder, W. J., Roberts, T. J., Brosnan, M. J., Heidbuchel, H., & Prior, D. L. (2015) · PLOS ONE · doi:10.1371/journal.pone.0130031 · Cited by 80 · see citing works
Self-citation
- Authors
- La Gerche, A., Connelly, K. A., Mooney, D. J., MacIsaac, A. I., & Prior, D. L.
- Affiliations
- The University of Melbourne (AU)
- St Vincent's Hospital Melbourne (AU)
- Venue
- Heart
- Publisher
- BMJ
- Published
- 2007-05-04
- Volume
- 94
- Issue
- 7
- Pages
- 860-866
- ISSN
- 1355-6037 (ISSN-L)
- 1468-201X
- OpenAlex
- W2098655842
- Cited by
- 258
- References
- 2
- Citations by year
- 2026: 4 · 2025: 3 · 2024: 12 · 2023: 12 · 2022: 15 · 2021: 16 · 2020: 11 · 2019: 9 · 2018: 11 · 2017: 14 · 2016: 16 · 2015: 15 · 2014: 23 · 2013: 16 · 2012: 22
- FWCI
- 10.80
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Heart (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Heart Foundation of Australia
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Effects of Exercise
- Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Takotsubo Cardiomyopathy and Associated Phenomena
- Keywords
- ultra-endurance exercise, exercise-induced myocardial injury, right ventricular dysfunction, left ventricular function, cardiac troponin I, brain natriuretic peptide, triathlon, regional wall motion abnormalities, systolic strain, fractional area change, tricuspid annular plane systolic excursion, athletes, sudden cardiac death risk
- MeSH terms
- Adult, Female, Humans, Male, Middle Aged, Physical Endurance, Biomarkers, Exercise, Ventricular Dysfunction, Left, Ventricular Dysfunction, Right, Echocardiography, Doppler, Color, Troponin I, Natriuretic Peptide, Brain
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