The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Ventricular size and function assessed by cardiac MRI predict major adverse clinical outcomes late after tetralogy of Fallot repair
Abstract
Background: Factors associated with impaired clinical status in a cross-sectional study of patients with repaired tetralogy of Fallot (TOF) have been reported previously. Objectives: To determine independent predictors of major adverse clinical outcomes late after TOF repair in the same cohort during follow-up evaluated by cardiac magnetic resonance (CMR). Methods: Clinical status at latest follow-up was ascertained in 88 patients (median time from TOF repair to baseline evaluation 20.7 years; median follow-up from baseline evaluation to most recent follow-up 4.2 years). Major adverse outcomes included ( a ) death; ( b ) sustained ventricular tachycardia; and ( c ) increase in NYHA class to grade III or IV. Results: 22 major adverse outcomes occurred in 18 patients (20.5%): death in 4, sustained ventricular tachycardia in 8, and increase in NYHA class in 10. Multivariate analysis identified right ventricular (RV) end-diastolic volume Z ⩾7 (odds ratio (OR) = 4.55, 95% confidence interval (CI) 1.10 to 18.8, p = 0.037) and left ventricular (LV) ejection fraction <55% (OR = 8.05, 95% CI 2.14 to 30.2, p = 0.002) as independent predictors of outcome with an area under the receiver operator characteristic curve of 0.850. LV ejection fraction could be replaced by RV ejection fraction <45% in the multivariate model. QRS duration ⩾180 ms also predicted major adverse events but correlated with RV size. Conclusions: In this cohort, severe RV dilatation and either LV or RV dysfunction assessed by CMR predicted major adverse clinical events. This information may guide risk stratification and therapeutic interventions.
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Gatzoulis, M. A., Balaji, S., Webber, S. A., Siu, S. C., Hokanson, J. S., Poile, C., Rosenthal, M., Nakazawa, M., Moller, J. H., Gillette, P. C., et al. (2000) · The Lancet · doi:10.1016/s0140-6736(00)02714-8 · Cited by 1,779
Long-term outcome in patients undergoing surgical repair of tetralogy of Fallot
Murphy, J. G., Gersh, B. J., Mair, D. D., Fuster, V., McGoon, M. D., Ilstrup, D. M., McGoon, D. C., Kirklin, J. W., & Danielson, G. K. (1993) · New England Journal of Medicine · doi:10.1056/nejm199308263290901 · Cited by 998
Nollert, G., Fischlein, T., Bouterwek, S., Böhmer, C., Klinner, W., & Reichart, B. (1997) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(97)00318-5 · Cited by 761
Geva, T., Sandweiss, B. M., Gauvreau, K., Lock, J. E., & Powell, A. J. (2004) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2003.10.045 · Cited by 620
Self-citationRight and left ventricular systolic function late after repair of tetralogy of Fallot.
Gatzoulis, M. A., Elliott, J. T., Guru, V., Siu, S. C., Warsi, M. A., Webb, G. D., Williams, W. G., Liu, P., & McLaughlin, P. R. (2000) · The American Journal of Cardiology · doi:10.1016/s0002-9149(00)01241-8 · Cited by 108
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Warnes, C. A., Williams, R. G., Bashore, T. M., Child, J. S., Connolly, H. M., Dearani, J. A., del Nido, P., Fasules, J. W., Graham, T. P., Hijazi, Z. M., et al. (2008) · Circulation · doi:10.1161/circulationaha.108.190811 · Cited by 2,066
Self-citationStout, K. K., Daniels, C. J., Aboulhosn, J. A., Bozkurt, B., Broberg, C. S., Colman, J. M., Crumb, S. R., Dearani, J. A., Fuller, S., Gurvitz, M., et al. (2019) · Circulation · doi:10.1161/cir.0000000000000603 · Cited by 1,602
Self-citation2018 AHA/ACC Guideline for the Management of Adults With Congenital Heart Disease
Stout, K. K., Daniels, C. J., Aboulhosn, J. A., Bozkurt, B., Broberg, C. S., Colman, J. M., Crumb, S. R., Dearani, J. A., Fuller, S., Gurvitz, M., et al. (2019) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2018.08.1029 · Cited by 1,080
Self-citationKhairy, P., Van Hare, G. F., Balaji, S., Berul, C. I., Cecchin, F., Cohen, M. I., Daniels, C. J., Deal, B. J., Dearani, J. A., Groot, N. D., et al. (2014) · Heart Rhythm · doi:10.1016/j.hrthm.2014.05.009 · Cited by 709
Self-citationAl-Khatib, S. M., Stevenson, W. G., Ackerman, M. J., Bryant, W. J., Callans, D. J., Curtis, A. B., Deal, B. J., Dickfeld, T., Field, M. E., Fonarow, G. C., et al. (2018) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2017.10.053 · Cited by 678
Metadata
- Authors
- Knauth, A. L., Gauvreau, K., Powell, A. J., Landzberg, M. J., Walsh, E. P., Lock, J. E., Nido, P. J. D., & Geva, T.
- Venue
- Heart
- Publisher
- BMJ
- Published
- 2006-11-29
- Volume
- 94
- Issue
- 2
- Pages
- 211-216
- ISSN
- 1355-6037 (ISSN-L)
- 1468-201X
- OpenAlex
- W2096174447
- Cited by
- 495
- References
- 5
- FWCI
- 9.74
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Ventricular size and function assessed by cardiac MRI predict major adverse clinical outcomes late after tetralogy of Fallot repair. https://app.cochat.ai/papers/10.1136/hrt.2006.104745
- The paper
- Knauth, A. L., Gauvreau, K., Powell, A. J., Landzberg, M. J., Walsh, E. P., Lock, J. E., Nido, P. J. D., & Geva, T. (2008). Ventricular size and function assessed by cardiac MRI predict major adverse clinical outcomes late after tetralogy of Fallot repair. Heart. https://doi.org/10.1136/hrt.2006.104745
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