The DOI matches its Crossref record; 30 of the 31 references it cites were found in a registry or an index.
The effect of optimal medical therapy on 1-year mortality after acute myocardial infarction
Open accessAbstract
Objectives: Five drug classes have been shown to improve the prognosis of acute myocardial infarction in clinical trials: aspirin, β-blockers, statins, renin angiotensin system (RAS) blockers and thienopyridines. We aimed to assess whether the benefits of combining these drugs (termed optimal medical therapy, OMT), will result in a reduction of mortality in clinical practice. Design: Nationwide registry Setting: Hospitals with a cardiology unit or internal medicine department. Patients: 5353 patients with acute myocardial infarction. At hospital discharge 89% received aspirin, 90% β-blockers, 84% statins, 81% RAS blockers, 70% a thienopyridine and 46.2% OMT. Interventions: Pharmacotherapy Main outcome measures: OR with 95% CI for mortality from myocardial infarction were calculated and adjusted for patient risk at baseline. Results: Total mortality was reduced by 74% in patients receiving OMT (adj OR 0.26; 95% CI 0.18 to 0.38) versus patients receiving one or no drug. This was consistent in subgroups defined by STEMI/NSTEMI, diabetes and gender. Mortality was also reduced in patients receiving 2–4 drugs (adj OR 0.49; 95% CI 0.35 to 0.68), diabetic patients being the only subgroup with no significant effect. Analyses on the relative importance of either component revealed that withdrawal of β-blockers (adj OR 0.63; 95% CI 0.34 to 1.16) and/or a combination of aspirin/clopidogrel (adj OR 0.59; 95% CI 0.20 to 1.17) abolished the risk reduction conferred by OMT. Conclusions: OMT over 1 year was associated with a significantly lower mortality of patients with acute myocardial infarction in clinical practice. However OMT is provided to less than half of eligible patients leaving room for substantial improvement.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“However, only about half of all patients were discharged with optimal medical therapy in an observational study of 5353 patients with acute myocardial infarction compared with the standards in these guidelines.555”
From European Guidelines on cardiovascular disease prevention in clinical practice (version 2012) (2012) · cites this paper as [555]
In the citing paper
“patients discharged on less than optimal medical therapy have a worse 1-year prognosis.555”
From European Guidelines on cardiovascular disease prevention in clinical practice (version 2012) (2012) · cites this paper as [555]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Prasugrel versus clopidogrel in patients with acute coronary syndromes
Wiviott, S. D., Braunwald, E., McCabe, C. H., Montalescot, G., Ruzyllo, W., Gottlieb, S., Neumann, F.-J., Ardissino, D., De Servi, S., Murphy, S. A., et al. (2007) · New England Journal of Medicine · doi:10.1056/nejmoa0706482 · Cited by 6,790
Braunwald, E., Antman, E. M., Beasley, J. W., Califf, R. M., Cheitlin, M. D., Hochman, J. S., Jones, R. H., Kereiakes, D. J., Kupersmith, J., Levin, T. N., et al. (2000) · Circulation · doi:10.1161/01.cir.102.10.1193 · Cited by 4,475
Fox, K. A. A., Dabbous, O. H., Goldberg, R. J., Pieper, K. S., Eagle, K. A., de Werf, F. V., Avezum, Á., Goodman, S. G., Flather, M. D., Anderson, F. A., et al. (2006) · BMJ · doi:10.1136/bmj.38985.646481.55 · Cited by 1,699
Pitt, B., Segal, R., Martínez, F. A., Meurers, G., Cowley, A. J., Thomas, I., DEEDWANIA, P. C., Ney, D. E., Snavely, D. B., & Chang, P. (1997) · The Lancet · doi:10.1016/s0140-6736(97)01187-2 · Cited by 1,660
Tunstall-Pedoe, H., Kuulasmaa, K., Mähönen, M., Tolonen, H., & Ruokokoski, E. (1999) · The Lancet · doi:10.1016/s0140-6736(99)04021-0 · Cited by 1,444
D, E. B. M., Antman, E. M., Beasley, J. W., Califf, R. M., Cheitlin, M. D., Hochman, J. S., Jones, R. H., Kereiakes, D. J., Kupersmith, J., Levin, T. N., et al. (2002) · Circulation · doi:10.1161/01.cir.0000037106.76139.53 · Cited by 844
Impact of Medication Therapy Discontinuation on Mortality After Myocardial Infarction
Ho, P. M., Spertus, J. A., Masoudi, F. A., Reid, K. J., Peterson, E. D., Magid, D. J., Krumholz, H. M., & Rumsfeld, J. S. (2006) · Archives of Internal Medicine · doi:10.1001/archinte.166.17.1842 · Cited by 635
The APEX AMI Investigators (2007) · JAMA · doi:10.1001/jama.297.1.43 · Cited by 447
Flagged first, then by citations
1 of the 31 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Items 101–115 of 115
Knight, C. J., & Timmis, A. (2011) · Revista Portuguesa de Cardiologia · doi:10.1016/j.repc.2011.10.011
Knight, C. J., & Timmis, A. (2011) · Materia Socio Medica · doi:10.5455/msm.2011.23.161-170
Royo‐Bordonada, M. Á., Bejarano, J. M. L., Álvarez, F. V., Sans, S., Pérez, A., Pedro‐Botet, J., Carriles, R. M. M., Maiques, A., Lizcano‐Álvarez, A., Lizarbe, V., et al. (2013) · Avances en Diabetología · doi:10.1016/j.avdiab.2013.04.002
Comments on an acute myocardial infarction study
Bramlage, P., & Tebbe, U. (2010) · Heart · doi:10.1136/hrt.2010.205989
Self-citationRoyo‐Bordonada, M. Á., Bejarano, J. M. L., Alvarez, F. V., Sans, S., Pérez, A., Pedro‐Botet, J., Carriles, R. M. M., Maiques, A., Lizcano, Á., Lizarbe, V., et al. (2016) · Neurología (English Edition) · doi:10.1016/j.nrleng.2013.03.009
Stellenwert der Lyse im Rettungswesen
Hochreuther, S., Härtel, D., Brockmeier, J., Rohde, M., Machalke, K., Mendrok, H.-C., Bramlage, P., & Tebbe, U. (2014) · Humanmedizin kompakt · doi:10.1007/s40355-014-0021-1
Self-citationLong-term benefits of the cardiac rehabilitation programme in Girona: a three-year follow-up study
Garcia, E. C. (2017) · Universitat de Girona Digital Repository (Universitat de Girona)
Knight, C. J., & Timmis, A. (2012) · Revista Portuguesa de Cardiologia (English Edition) · doi:10.1016/j.repce.2012.01.006
(2021) · Elsevier eBooks · doi:10.1016/b978-3-437-23841-3.00041-2
Velásquez‐Rodríguez, J., Bruña, V., Vicent, L., Díez‐Delhoyo, F., Valero‐Masa, M. J., Sousa-Casasnovas, I., Juárez, M., Devesa, C., Fernández‐Avilés, F., & Martínez‐Sellés, M. (2021) · Revista Portuguesa de Cardiologia (English Edition) · doi:10.1016/j.repce.2020.07.013
Stellenwert der Lyse im Rettungswesen
Hochreuther, S., Härte, D., Brockmeier, J., Rohde, M., Machalke, K., Mendrok, H.-C., Bramlage, P., & Tebbe, U. (2015) · Springer eBooks · doi:10.1007/978-3-662-46523-3_3
Self-citationTansitpong, P. (2023) · Lecture notes in networks and systems · doi:10.1007/978-981-99-3243-6_2
Kwun, J.-S., Choi, J., Kim, S., Kang, D., Park, D., Park, S., Hur, S., Kim, W., Park, C. S., Lee, B., et al. (2023) · Research Square · doi:10.21203/rs.3.rs-3381072/v1
Metadata
- Authors
- Bramlage, P., Messer, C., Bitterlich, N., Pohlmann, C., Cuneo, A., Stammwitz, E., Tebbenjohanns, J., Gohlke, H., Senges, J., & Tebbe, U.
- Affiliations
- Klinikum Lippe (DE)
- Klinikum Lüdenscheid (DE)
- Universitäts-Herzzentrum Freiburg-Bad Krozingen (DE)
- Heidelberg University (DE)
- Corresponding author
- Tebbe, U
- Venue
- Heart
- Publisher
- BMJ
- Published
- 2010-03-29
- Volume
- 96
- Issue
- 8
- Pages
- 604-609
- ISSN
- 1355-6037 (ISSN-L)
- 1468-201X
- OpenAlex
- W2162467404
- Cited by
- 115
- References
- 31
- Citations by year
- 2024: 1 · 2023: 9 · 2022: 2 · 2021: 6 · 2020: 8 · 2019: 5 · 2018: 2 · 2017: 5 · 2016: 13 · 2015: 4 · 2014: 11 · 2013: 14 · 2012: 15
- FWCI
- 10.56
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Heart (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Acute Myocardial Infarction Research
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Antiplatelet Therapy and Cardiovascular Diseases
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Coronary Interventions and Diagnostics
- Keywords
- acute myocardial infarction, optimal medical therapy, one-year mortality, aspirin, beta-blockers, statins, renin-angiotensin system inhibitors, thienopyridines, clopidogrel, drug combination therapy, diabetes mellitus, guideline adherence, pharmacotherapy
- MeSH terms
- Aged, Cardiovascular Agents, Drug Therapy, Combination, Female, Hospitalization, Humans, Male, Middle Aged, Myocardial Infarction, Prospective Studies
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
