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Effect of submaximal exercise on fibrinolytic activity in ischaemic heart disease.
Open accessAbstract
Fibrinolytic activity and platelet adhesiveness are normal in cases of angina pectoris and healed myocardial infarction, whereas fibrinolytic activity is diminished in acute myocardial infarction. Exercise increases fibrinolytic activity in normal people but the effect on it of submaximal exercise in patients with ischaemic heart disease is not known. Resting platelet adhesiveness and fibrinolytic activity were determined in 20 patients suffering from ischaemic heart disease and eight healthy controls. Both groups were then subjected to submaximal exercise on a motor-driven treadmill. The ST segment of the electrocardiogram and the heart rate were monitored during exercise by an on-line digital computer. Fibrinolytic activity determinations were repeated immediately after exercise. There was a significant increase in fibrinolytic response in both groups but it was significantly less in the ischaemic groups (36-2%) compared with the controls (55-9%) (P less than 0-01). The ST segment depression was 2-3 mm in the ischaemic group and 0-52 mm in controls--also a significant difference (P less than 0-01). There was no correlation, however, between the ST change and the fibrinolytic response. A diminished response in the ischaemic group may favour their predisposition to thrombotic episodes.
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“Furthermore, other potential triggers, such as psychological stress or anger, which produce similar physiologic 38-41 are more common than heavy exertion responses,3 before myocardial infarction¹,³ and may be more frequent triggers.”
From Triggering of Acute Myocardial Infarction by Heavy Physical Exertion -- Protection against Triggering by Regular Exertion (1993) · cites this paper as [41]
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Research works printed but not linked: 21
- Astrup, T. (1956). The biological significance of fibrinolysis. Lancet, 2, 565. · DOI
- Balasubramanian, V., Khanna, P. K., and Hoon, R. S. (1975). On-line digital computer quantitated ST segment response to submaximal tread mill exercise. J3ournal of the Association of Physicians of India, 23, 1.
- Blix, S. (1961). Studies on the fibrinolytic system in the euglobulin fraction of human plasma. (a) Methodological study. (b) Application of the methods. Scandinavian Journal of Clinical and Laboratory Investigation, 13, Suppl. 58, 3.
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- Chandler, A. B., Chapman, I., Erhardt, L. R., Roberts, W. C., Schwartz, C. J., Sinapius, D., Spain, D. M., Sherry, S., Ness, P. M., and Simon, T. L. (1974). Coronary thrombosis in myocardial infarction. Report of a workshop on the role of coronary thrombosis in the pathogenesis of acute myocardial infarction. American J7ournal of Cardiology, 34, 823.
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- Greig, H. B. W. (1956). Inhibition of fibrinolysis in alimentary lipaemia. Lancet, 2, 16. · DOI
- Hellerestein, H. K. (1968). Exercise therapy in coronary disease. Bulletin of the New York Academy of Medicine, 44, 1028.
- Morris, J. N., and Crawford, M. D. (1958). Coronary heart disease and physical activity of work, evidence of a national necropsy survey. British Medical Journal, 2, 1485. · DOI
- Ogston, D., and Fullerton, H. W. (1961). Changes in fibrinolytic activity produced by physical activity. Lancet, 2, 730. · DOI
- Rojel, J. (1959). A study of fibrinolysin activity in thrombotic diseases. Acta Medica Scandinavica, 164, 81. · DOI
- Seth, H. N. (1973). Fibrinolytic response to moderate exercise and platelet adhesiveness in diabetes mellitus. Acta Diabetologica Latina, 10, 306. · DOI
- Shaw, D. A., and MacNaughton, D. (1963). Relationship between blood fibrinolytic activity and body fatness. Lancet, 1, 352. · DOI
- Sherry, S., Lindemeyer, R. I., Fletcher, A. P., and Alkjaersig, N. (1959). Studies of enhanced fibrinolytic activity in man. Journal of Clinical Investigation, 38, 810. · DOI
- Sikka, K. K., Nath, K., Samuel, K. C., Gahlaut, D. S., Srivastava, M. C., and Gaffar, A. (1967). Plasma fibrinolytic activity in diabetes mellitus. Journal of the Association of Physicians of India, 15, 279.
- Singh, I., Khanna, P. K., Srivastava, M. C., and Hoon, R. S. (1970). Extent ofpossible rehabilitation of service personnel with ischaemic heart disease. British Heart Journal, 32, 665. · DOI
- Sinha, B. C., Ghosh, B. P., and Misra, H. (1960) Further studies on inhibition of fibrinolysis in coronary and cerebral thombosis cases. Indian Heart Journal, 12, 197.
Cited by
Mittleman, M. A., Maclure, M., Tofler, G. H., Sherwood, J. B., Goldberg, R. J., & Muller, J. E. (1993) · New England Journal of Medicine · doi:10.1056/nejm199312023292301 · Cited by 1,431
Stone agers in the fast lane: chronic degenerative diseases in evolutionary perspective
Eaton, S. B., Konner, M., & Shostak, M. (1988) · The American Journal of Medicine · doi:10.1016/0002-9343(88)90113-1 · Cited by 703
Metadata
- Authors
- Khanna, P. K., Seth, H. N., Balasubramanian, V, & Hoon, R. S.
- Venue
- Heart
- Publisher
- BMJ
- Published
- 1975-12-01
- Volume
- 37
- Issue
- 12
- Pages
- 1273-1276
- ISSN
- 1355-6037 (ISSN-L)
- PMC
- PMC482952
- OpenAlex
- W2135240539
- Cited by
- 22
- References
- 0
- Citations by year
- 2024: 1
- FWCI
- 0.00
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Heart (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- HighWire Press Open Archive (submittedVersion)
- Topics
- Health Sciences › Medicine › Hematology › Blood Coagulation and Thrombosis Mechanisms
- Health Sciences › Medicine › Hematology › Blood properties and coagulation
- Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
- Keywords
- fibrinolytic activity, submaximal exercise, ischemic heart disease, platelet adhesion, angina pectoris, myocardial infarction, ST-segment depression, thrombosis, treadmill exercise
- MeSH terms
- Adult, Coronary Disease, Electrocardiography, Physical Exertion, Fibrinolysis, Heart Rate, Humans, Male, Middle Aged, Platelet Adhesiveness
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