The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Heart rate variability in healthy subjects: effect of age and the derivation of normal ranges for tests of autonomic function.
Open accessAbstract
The diagnosis of autonomic neuropathy frequently depends on results of tests which elicit reflex changes in heart rate. Few well-documented normal ranges are available for these tests. The present study was designed to investigate the effect of age upon heart rate variability at rest and in response to a single deep breath, the Valsalva manoeuvre, and standing. A computerised method of measurement of R-R interval variation was used to study heart rate responses in 310 healthy subjects aged 18-85 years. Heart rate variation during each procedure showed a skewed distribution and a statistically significant negative correlation with age. Normal ranges (90% and 95% confidence limits) for subjects aged 20-75 years were calculated for heart rate difference (max-min) and ratio (max/min) and standard deviation (SD). Heart rate responses were less than the 95th centile in at least one of the four procedures in 39 (12.6%) out of the 310 subjects, and were below this limit in two or more tests in five (1.6%) subjects. In view of the decline in heart rate variation with increasing age, normal ranges for tests of autonomic function must be related to the age of the subject.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Sympathetic Nervous System and Aging in Man
ROWE, J. W., & TROEN, B. R. (1980) · Endocrine Reviews · doi:10.1210/edrv-1-2-167 · Cited by 255
Cited by
Heart Rate Variability: Standards of Measurement, Physiological Interpretation, and Clinical Use
Electrophysiology, T. F. O. T. E. S. O. C. T. N. A. (1996) · Circulation · doi:10.1161/01.cir.93.5.1043 · Cited by 17,159
Umetani, K., Singer, D. H., McCraty, R., & Atkinson, M. (1998) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(97)00554-8 · Cited by 1,145
Malik, M. (1996) · Annals of Noninvasive Electrocardiology · doi:10.1111/j.1542-474x.1996.tb00275.x · Cited by 850
Malik, M., & Camm, A. J. (1990) · Clinical Cardiology · doi:10.1002/clc.4960130811 · Cited by 722
Adrenergic and Muscarinic Receptors in the Human Heart
Brodde, O.-E., & Michel, M. C. (1999) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01425-x · Cited by 673
Metadata
- Authors
- O'Brien, I. A., O'Hare, P., & Corrall, R. J.
- Venue
- Heart
- Publisher
- BMJ
- Published
- 1986-04-01
- Volume
- 55
- Issue
- 4
- Pages
- 348-354
- ISSN
- 1355-6037 (ISSN-L)
- OpenAlex
- W2053016376
- Cited by
- 483
- References
- 1
- FWCI
- 7.23
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Heart rate variability in healthy subjects: effect of age and the derivation of normal ranges for tests of autonomic function. https://app.cochat.ai/papers/10.1136/hrt.55.4.348
- The paper
- O'Brien, I. A., O'Hare, P., & Corrall, R. J. (1986). Heart rate variability in healthy subjects: effect of age and the derivation of normal ranges for tests of autonomic function. Heart. https://doi.org/10.1136/hrt.55.4.348
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
