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QT dispersion: an indication of arrhythmia risk in patients with long QT intervals.
Open accessAbstract
Homogeneity of recovery time protects against arrhythmias whereas dispersion of recovery time is arrhythmogenic. A single surface electrocardiographic QT interval gives no information on recovery time dispersion but the difference between the maximum and minimum body surface QT interval may be relevant. This hypothesis was tested by measuring the dispersion of the corrected QT interval (QTc) in 10 patients with an arrhythmogenic long QT interval (Romano Ward and Jervell and Lange-Nielsen syndromes or drug arrhythmogenicity) and in 14 patients without arrhythmias in whom the QT interval was prolonged by sotalol. QTc dispersion was significantly greater in the arrhythmogenic QT group than in the sotalol QT group. In patients with prolonged QT intervals, QT dispersion distinguished between those with ventricular arrhythmias and those without. This supports the hypothesis that QT dispersion reflects spatial differences in myocardial recovery time. QT dispersion may be useful in the assessment of both arrhythmia risk and the efficacy of antiarrhythmic drugs.
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Citations
Cited by
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Measurement, interpretation and clinical potential of QT dispersion
Malik, M., & Batchvarov, V. N. (2000) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(00)00962-1 · Cited by 631
QTc-interval abnormalities and psychotropic drug therapy in psychiatric patients
Reilly, J., Ayis, S., Ferrier, I., Jones, S., & Thomas, S. (2000) · The Lancet · doi:10.1016/s0140-6736(00)02035-3 · Cited by 602
Mechanisms of abnormal cardiac repolarization during insulin-induced hypoglycemia
Robinson, R. T. C. E., Harris, N. D., Ireland, R. H., Lee, S., Newman, C., & Heller, S. R. (2003) · Diabetes · doi:10.2337/diabetes.52.6.1469 · Cited by 264
Increased QT dispersion during hypoglycaemia in patients with type 2 diabetes mellitus
Landstedt‐Hallin, L., Englund, A., Adamson, U., & Lins, P. ‐. (1999) · Journal of Internal Medicine · doi:10.1046/j.1365-2796.1999.00528.x · Cited by 141
Metadata
- Authors
- Day, C. P., McComb, J. M., & Campbell, R. W.
- Venue
- Heart
- Publisher
- BMJ
- Published
- 1990-06-01
- Volume
- 63
- Issue
- 6
- Pages
- 342-344
- ISSN
- 1355-6037 (ISSN-L)
- OpenAlex
- W2161999690
- Cited by
- 1,189
- References
- 0
- FWCI
- 7.34
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Day, C. P., McComb, J. M., & Campbell, R. W. (1990). QT dispersion: an indication of arrhythmia risk in patients with long QT intervals. Heart. https://doi.org/10.1136/hrt.63.6.342
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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