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Alterations in glycosylation as biomarkers for cancer detection
Abstract
Glycoconjugates constitute a major class of biomolecules which include glycoproteins, glycosphingolipids and proteoglycans. Glycans are involved in several physiological and pathological conditions, such as host–pathogen interactions, cell differentiation, migration, tumour invasion and metastisation, cell trafficking and signalling. Cancer is associated with glycosylation alterations in glycoproteins and glycolipids. This review describes various aspects of protein glycosylation with the focus on alterations associated with human cancer. The application of these glycosylation modifications as biomarkers for cancer detection in tumour tissues and serological assays is summarised.
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Cited by
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Yingli, H., Ping, Y., Jun, Y., & Xingwang, Z. (2025) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2025.167853 · Cited by 7
Metadata
- Authors
- Reis, C. A., Osorio, H., Silva, L., Gomes, C., & David, L.
- Venue
- Journal of Clinical Pathology
- Publisher
- BMJ
- Published
- 2010-03-30
- Volume
- 63
- Issue
- 4
- Pages
- 322-329
- ISSN
- 0021-9746 (ISSN-L)
- 1472-4146
- OpenAlex
- W2037876225
- Cited by
- 432
- References
- 0
- FWCI
- 12.29
- Type
- journal article
- Language
- en
- Open access
- closed
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- Reis, C. A., Osorio, H., Silva, L., Gomes, C., & David, L. (2010). Alterations in glycosylation as biomarkers for cancer detection. Journal of Clinical Pathology. https://doi.org/10.1136/jcp.2009.071035
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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