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Cited by 37Air Quality and Health ImpactsHeart Rate Variability and Autonomic ControlGenetic Associations and Epidemiology

Lipid and endothelium-related genes, ambient particulate matter, and heart rate variability—the VA Normative Aging Study

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Ren, C, Baccarelli, A, Wilker, E, Suh, H, Sparrow, D, Vokonas, P, Wright, R, Schwartz, J·2010·Journal of Epidemiology and Community Health
DOI 10.1136/jech.2008.083295PMC PMC3935361
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Abstract

Background: Many studies have shown that exposures to air pollution are associated with cardiovascular events, although the mechanism remains to be clarified. To identify whether exposures to ambient particles act on autonomic function via the lipid/endothelial metabolism pathway, whether effects of particulate matter <2.5 μm in aerodynamic diameter (PM 2.5) on heart rate variability (HRV) were modified by gene polymorphisms related to those pathways were evaluated. Methods: HRV and gene data from the Normative Aging Study and PM 2.5 from a monitor located a kilometre from the examination site were used. A mixed model was fitted to investigate the associations between PM 2.5 and repeated measurements of HRV by gene polymorphisms of apolipoprotein E (APOE), lipoprotein lipase (LPL) and vascular endothelial growth factor (VEGF) adjusting for potential confounders chosen a priori. Results: A 10 μg/m 3 increase in PM 2.5 in the 2 days before the examination was associated with 3.8% (95% CI 0.2% to 7.4%), 7.8% (95 CI 0.4% to 15.3%) and 10.6% (95% CI 1.8% to 19.4%) decreases of the standard deviation of normal-to-normal intervals, the low frequency and the high frequency, respectively. Overall, carriers of wild-type APOE, LPL and VEGF genes had stronger effects of particles on HRV than those with hetero- or homozygous types. Variations of LPL-N291S, LPL-D9N and APOE-G113C significantly modified effects of PM 2.5 on HRV. Conclusion: Associations between PM 2.5 and HRV were modified by gene polymorphisms of APOE, LPL and VEGF; the biological metabolism remains to be identified.

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  • Epidemiological studies reveal positive associations between PM2.5 exposure and plasma homocysteine levels.

    “Epidemiological studies also reveal positive associations between PM2.5 exposure and plasma homocysteine levels, an established marker of cardiovascular disease risk [156].”

    From Air pollution and children’s health—a review of adverse effects associated with prenatal exposure from fine to ultrafine particulate matter (2021) · cites this paper as [156]

    The Results report that higher PM2.5 exposure was associated with lower heart rate variability, not higher plasma homocysteine. Searches of our full-text copy for homocysteine and its proposed cardiovascular-risk role found no passage addressing the claimed association; no page numbers were available. (LLM, conf=0.74)

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Authors
Ren, C., Baccarelli, A., Wilker, E., Suh, H., Sparrow, D., Vokonas, P., Wright, R., & Schwartz, J.
Affiliations
  • Harvard University (US)
  • University of Milan (IT)
  • Boston University (US)
  • Boston Children's Hospital (US)
Corresponding author
Ren, C
ORCID
Venue
Journal of Epidemiology and Community Health
Publisher
BMJ
Published
2009-07-13
Volume
64
Issue
01
Pages
49-56
ISSN
  • 0141-7681 (ISSN-L)
  • 0143-005X
  • 1470-2738
DOI
10.1136/jech.2008.083295
PMC
PMC3935361
OpenAlex
W2133547657
Cited by
37
References
1
Citations by year
2026: 4 · 2025: 4 · 2022: 1 · 2021: 4 · 2020: 4 · 2019: 1 · 2018: 1 · 2016: 4 · 2015: 2 · 2014: 1 · 2013: 1 · 2012: 4
FWCI
2.37
Type
journal article
Language
en
Open access
Locations
  • Journal of Epidemiology & Community Health (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
  • HighWire Press Open Archive (submittedVersion)
Funders
  • National Institutes of Health (5r01es005257-15)
  • National Institute of Environmental Health Sciences (P 42-ES05947, R01-ES005257, ES-014663, R01ES014663, P01_ES008925, P42ES005947, P30ES000002, ES 05257, R01ES010798, R01ES015172, ES10798, ES 00002)
Topics
  • Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Air Quality and Health Impacts
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
Keywords
particulate matter, PM2.5, air pollution, heart rate variability, autonomic function, genetic polymorphism, apolipoprotein E, lipoprotein lipase, vascular endothelial growth factor, lipid metabolism, endothelial function, gene-environment interaction, cardiovascular effects of air pollution, Normative Aging Study
MeSH terms
Aged, Aged, 80 and over, Air Pollutants, Apolipoproteins E, Endothelium, Genotype, Heart Rate, Humans, Lipoprotein Lipase, Longitudinal Studies, Male, Polymorphism, Genetic, Vascular Endothelial Growth Factor A, Particulate Matter

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