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Cited by 554

The DOI matches its Crossref record; 55 of the 55 references it cites were found in a registry or an index.

Guidelines for the clinical management of Lynch syndrome (hereditary non-polyposis cancer)

Open access
Vasen, H F A, Möslein, G, Alonso, A, Bernstein, I, Bertario, L, Blanco, I, Burn, J, Capella, G, Engel, C, Frayling, I, Friedl, W, Hes, F J, Hodgson, S, Mecklin, J-P, Møller, P, Nagengast, F, Parc, Y, Renkonen-Sinisalo, L, Sampson, J R, Stormorken, A, Wijnen, J·2007·Journal of Medical Genetics
DOI 10.1136/jmg.2007.048991
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Abstract

Lynch syndrome (hereditary non-polyposis colorectal cancer) is characterised by the development of colorectal cancer, endometrial cancer and various other cancers, and is caused by a mutation in one of the mismatch repair genes: MLH1, MSH2, MSH6 or PMS2. The discovery of these genes, 15 years ago, has led to the identification of large numbers of affected families. In April 2006, a workshop was organised by a group of European experts in hereditary gastrointestinal cancer (the Mallorca-group), aiming to establish guidelines for the clinical management of Lynch syndrome. 21 experts from nine European countries participated in this workshop. Prior to the meeting, various participants prepared the key management issues of debate according to the latest publications. A systematic literature search using Pubmed and the Cochrane Database of Systematic Reviews reference lists of retrieved articles and manual searches of relevant articles was performed. During the workshop, all recommendations were discussed in detail. Because most of the studies that form the basis for the recommendations were descriptive and/or retrospective in nature, many of them were based on expert opinion. The guidelines described in this manuscript may be helpful for the appropriate management of families with Lynch syndrome. Prospective controlled studies should be undertaken to improve further the care of these families.

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Cites

Show all 55 references

Research works printed but not linked: 16

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Metadata

Authors
Vasen, H. F. A., Möslein, G., Alonso, A., Bernstein, I., Bertario, L., Blanco, I., Burn, J., Capella, G., Engel, C., Frayling, I., Friedl, W., Hes, F. J., Hodgson, S., Mecklin, J.-P., Møller, P., Nagengast, F., Parc, Y., Renkonen-Sinisalo, L., Sampson, J. R., Stormorken, A., & Wijnen, J.
Venue
Journal of Medical Genetics
Publisher
BMJ
Published
2007-02-27
Volume
44
Issue
6
Pages
353-362
ISSN
  • 0022-2593 (ISSN-L)
  • 1468-6244
DOI
10.1136/jmg.2007.048991
OpenAlex
W2068400231
Cited by
554
References
55
FWCI
35.43
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Guidelines for the clinical management of Lynch syndrome (hereditary non-polyposis cancer). https://app.cochat.ai/papers/10.1136/jmg.2007.048991
The paper
Vasen, H. F. A., Möslein, G., Alonso, A., Bernstein, I., Bertario, L., Blanco, I., Burn, J., Capella, G., Engel, C., Frayling, I., Friedl, W., Hes, F. J., Hodgson, S., Mecklin, J.-P., Møller, P., Nagengast, F., Parc, Y., Renkonen-Sinisalo, L., Sampson, J. R., . . . Wijnen, J. (2007). Guidelines for the clinical management of Lynch syndrome (hereditary non-polyposis cancer). Journal of Medical Genetics. https://doi.org/10.1136/jmg.2007.048991

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.