Minocycline promotes dendritic spine maturation and improves behavioural performance in the fragile X mouse model

Background: Fragile X syndrome (FXS) is the most common single gene inherited form of mental retardation, with behaviours at the extreme of the autistic spectrum. Subjects with FXS and fragile X mental retardation gene knock out ( Fmr1 KO) mice, an animal model for FXS, have been shown to exhibit…