Epidemiology and clinical features of amyotrophic lateral sclerosis in Ireland between 1995 and 2004
Abstract
Background We conducted a prospective, population based study to examine trends in incidence and prevalence of amyotrophic lateral sclerosis (ALS) in Ireland from 1995 to 2004. Methods The Irish ALS Register was used to identify Irish residents diagnosed with ALS between the 3 year period from 1 January 1995 to 31 December 1997 and the 3 year period from 1 January 2002 to 31 December 2004. Results 465 Irish residents were diagnosed with ALS during the study periods. The annual incidence rate of ALS in Ireland remained stable over this time (2.0 cases per 100,000 person-years; 95% CI 1.9, 2.2). Median survival of Irish ALS patients was 16.4 months and did not change during the study period. Demographics and clinical features of the incident and prevalent Irish ALS cohorts were markedly different.
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The median survival time is well within the range reported by several population-based studies, which extends from 16 months to 28 months, with most studies reporting values between 19 and 23 months.
“it is well within the range reported by several population-based studies, which extends from 16 months (65;66) to 28 months (67), with most studies reporting values between 19 and 23 months (68–70).”
From Association of ALS with head injury, cigarette smoking and APOE genotypes (2010) · cites this paper as [65]
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- Authors
- O'Toole, O., Traynor, B. J., Brennan, P., Sheehan, C., Frost, E., Corr, B., & Hardiman, O.
- Venue
- Journal of Neurology, Neurosurgery & Psychiatry
- Publisher
- BMJ
- Published
- 2008-01-01
- Volume
- 79
- Issue
- 1
- Pages
- 30-32
- ISSN
- 0022-3050
- Cited by
- 160
- References
- 0
- Language
- en
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