Cited by 612Amyotrophic Lateral Sclerosis ResearchDementia and Cognitive Impairment ResearchAlzheimer's disease research and treatments

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Clinical, genetic and pathological heterogeneity of frontotemporal dementia: a review

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Seelaar, H., Rohrer, J. D., Pijnenburg, Y. A. L., Fox, N. C., van Swieten, J. C.·2011·Journal of Neurology, Neurosurgery & Psychiatry

DOI 10.1136/jnnp.2010.212225

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Abstract

Frontotemporal dementia (FTD) is the second most common young-onset dementia and is clinically characterised by progressive behavioural change, executive dysfunction and language difficulties. Three clinical syndromes, behavioural variant FTD, semantic dementia and progressive non-fluent aphasia, form part of a clinicopathological spectrum named frontotemporal lobar degeneration (FTLD). The classical neuropsychological phenotype of FTD has been enriched by tests exploring Theory of Mind, social cognition and emotional processing. Imaging studies have detailed the patterns of atrophy associated with different clinical and pathological subtypes. These patterns offer some diagnostic utility, while measures of progression of atrophy may be of use in future trials. 30-50% of FTD is familial, and mutations in two genes, microtubule associated protein tau and Progranulin (GRN), account for about half of these cases. Rare defects in VCP, CHMP2B, TARDP and FUS genes have been found in a small number of families. Linkage to chromosome 9p13.2-21.3 has been established in familial FTD with motor neuron disease, although the causative gene is yet to be identified. Recent developments in the immunohistochemistry of FTLD, and also in amyotrophic lateral sclerosis (ALS), have led to a new pathological nomenclature. The two major groups are those with tau-positive inclusions (FTLD-tau) and those with ubiquitin-positive and TAR DNA-binding protein of 43 kDa (TDP-43) positive inclusions (FTLD-TDP). Recently, a new protein involved in familial ALS, fused in sarcoma (FUS), has been found in FTLD patients with ubiquitin-positive and TDP-43-negative inclusions. In this review, the authors discuss recent clinical, neuropsychological, imaging, genetic and pathological developments that have changed our understanding of FTD, its classification and criteria. The potential to establish an early diagnosis, predict underlying pathology during life and quantify disease progression will all be required for disease-specific therapeutic trials in the future.

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Santos‐García, I., Rodríguez‐Cueto, C., Villegas, P., Piscitelli, F., Lauritano, A., Shen, C.-K. J., Marzo, V. D., Fernández‐Ruíz, J., & de Lago, E. (2024) · Figshare · doi:10.6084/m9.figshare.26587587
Additional file 1 of Preclinical investigation in FAAH inhibition as a neuroprotective therapy for frontotemporal dementia using TDP-43 transgenic male mice
Santos‐García, I., Rodríguez‐Cueto, C., Villegas, P., Piscitelli, F., Lauritano, A., Shen, C.-K. J., Marzo, V. D., Fernández‐Ruíz, J., & de Lago, E. (2024) · Figshare · doi:10.6084/m9.figshare.26587584
Additional file 1 of Exploring experiences and needs of spousal carers of people with behavioural variant frontotemporal dementia (bvFTD) including those with familial FTD (fFTD): a qualitative study
Tookey, S., Greaves, C. V., Rohrer, J. D., Desai, R., & Stott, J. C. H. (2022) · Figshare · doi:10.6084/m9.figshare.19321405
Self-citation
Additional file 5 of Preclinical investigation in FAAH inhibition as a neuroprotective therapy for frontotemporal dementia using TDP-43 transgenic male mice
Santos‐García, I., Rodríguez‐Cueto, C., Villegas, P., Piscitelli, F., Lauritano, A., Shen, C.-K. J., Marzo, V. D., Fernández‐Ruíz, J., & de Lago, E. (2024) · Figshare · doi:10.6084/m9.figshare.26587596
Additional file 3 of Preclinical investigation in FAAH inhibition as a neuroprotective therapy for frontotemporal dementia using TDP-43 transgenic male mice
Santos‐García, I., Rodríguez‐Cueto, C., Villegas, P., Piscitelli, F., Lauritano, A., Shen, C.-K. J., Marzo, V. D., Fernández‐Ruíz, J., & de Lago, E. (2024) · Figshare · doi:10.6084/m9.figshare.26587590
Additional file 8 of Preclinical investigation in FAAH inhibition as a neuroprotective therapy for frontotemporal dementia using TDP-43 transgenic male mice
Santos‐García, I., Rodríguez‐Cueto, C., Villegas, P., Piscitelli, F., Lauritano, A., Shen, C.-K. J., Marzo, V. D., Fernández‐Ruíz, J., & de Lago, E. (2024) · Figshare · doi:10.6084/m9.figshare.26587605
Additional file 1 of Elevated CSF and plasma complement proteins in genetic frontotemporal dementia: results from the GENFI study
van der Ende, E. L., Heller, C., Sogorb‐Esteve, A., Swift, I. J., McFall, D. J., Peakman, G., Bouzigues, A., Poos, J. M., Jiskoot, L. C., Panman, J. L., et al. (2022) · Figshare · doi:10.6084/m9.figshare.20968112
Self-citation
Additional file 6 of Preclinical investigation in FAAH inhibition as a neuroprotective therapy for frontotemporal dementia using TDP-43 transgenic male mice
Santos‐García, I., Rodríguez‐Cueto, C., Villegas, P., Piscitelli, F., Lauritano, A., Shen, C.-K. J., Marzo, V. D., Fernández‐Ruíz, J., & de Lago, E. (2024) · Figshare · doi:10.6084/m9.figshare.26587599
Additional file 9 of Preclinical investigation in FAAH inhibition as a neuroprotective therapy for frontotemporal dementia using TDP-43 transgenic male mice
Santos‐García, I., Rodríguez‐Cueto, C., Villegas, P., Piscitelli, F., Lauritano, A., Shen, C.-K. J., Marzo, V. D., Fernández‐Ruíz, J., & de Lago, E. (2024) · Figshare · doi:10.6084/m9.figshare.26587608
Additional file 4 of Preclinical investigation in FAAH inhibition as a neuroprotective therapy for frontotemporal dementia using TDP-43 transgenic male mice
Santos‐García, I., Rodríguez‐Cueto, C., Villegas, P., Piscitelli, F., Lauritano, A., Shen, C.-K. J., Marzo, V. D., Fernández‐Ruíz, J., & de Lago, E. (2024) · Figshare · doi:10.6084/m9.figshare.26587593
The Dementia Cascade: From the Preclinical Stage
Chen, Q., Xu, J., Gao, H., & Cai, H. (2026) · Springer eBooks · doi:10.1007/978-981-95-5222-1_1
Depression and apathy in frontotemporal dementia: a short assessment of facts and outlook
Jellinger, K. A. (2026) · Journal of Neural Transmission · doi:10.1007/s00702-025-03101-z

Authors: Seelaar, H., Rohrer, J. D., Pijnenburg, Y. A. L., Fox, N. C., & van Swieten, J. C.
Affiliations: Erasmus MC (NL)
National Hospital for Neurology and Neurosurgery (GB)
Amsterdam UMC Location Vrije Universiteit Amsterdam (NL)
ORCID: Seelaar, H.
Rohrer, J. D.
Pijnenburg, Y. A. L.
Fox, N. C.
Venue: Journal of Neurology, Neurosurgery & Psychiatry
Publisher: BMJ
Published: 2010-10-22
Volume: 82
Issue: 5
Pages: 476-486
ISSN: 0022-3050 (ISSN-L)
DOI: 10.1136/jnnp.2010.212225
OpenAlex: W2102932082
Cited by: 609
References: 222
Citations by year: 2026: 16 · 2025: 22 · 2024: 39 · 2023: 23 · 2022: 35 · 2021: 33 · 2020: 44 · 2019: 42 · 2018: 34 · 2017: 31 · 2016: 49 · 2015: 41 · 2014: 45 · 2013: 65 · 2012: 54
FWCI: 6.24
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Journal of Neurology Neurosurgery & Psychiatry (publishedVersion)
PubMed (publishedVersion)
Amsterdam UMC (VU Amsterdam) - Institutional Repository (publishedVersion)
HAL (submittedVersion, other-oa)
Digital Academic REpository of VU University Amsterdam (Vrije Universiteit Amsterdam) (submittedVersion)
UCL Discovery (University College London) (submittedVersion)
HighWire Press Open Archive (submittedVersion)
Pure Amsterdam UMC (submittedVersion)
Trinity's Access to Research Output (TARA) (Trinity College Dublin) (submittedVersion)
Data Archiving and Networked Services (DANS) (submittedVersion)
Funders: Alzheimer's Research Trust
National Institute for Health and Care Research (NF-SI-0508-10123)
Hersenstichting
Stichting Dioraphte
Medical Research Council
Topics: Health Sciences › Medicine › Clinical Neurology › Amyotrophic Lateral Sclerosis Research
Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Keywords: frontotemporal dementia, frontotemporal lobar degeneration, semantic dementia, progressive nonfluent aphasia, tauopathy, TDP-43, FUS, progranulin, tau protein, VCP, CHMP2B, amyotrophic lateral sclerosis, neuroimaging, brain atrophy, neuropsychological assessment, disease progression, early diagnosis, genetic heterogeneity
MeSH terms: Progranulins, Brain, Cognition, Humans, Magnetic Resonance Imaging, Risk Factors, Social Perception, Biomarkers, tau Proteins, Intercellular Signaling Peptides and Proteins, Executive Function, Frontotemporal Dementia

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Clinical, genetic and pathological heterogeneity of frontotemporal dementia: a review

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