ABNORMALITY OF THE BLOOD-CEREBROSPINAL FLUID BARRIER OF PATIENTS SUFFERING FROM A DEPRESSIVE ILLNESS
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This is the first study to provide direct evidence that chronic stress is sufficient to allow infiltration of circulating cytokines in the absence of local mechanical trauma or a brain tumor.
“To our knowledge, this is the first study to provide direct evidence that chronic stress is sufficient to allow infiltration of circulating cytokines in the absence of local mechanical trauma or a brain tumor41, 42.”
From Social stress induces neurovascular pathology promoting depression (2017) · cites this paper as [41]
The Summary (page not provided) reports reduced entry of radioactive sodium into cerebrospinal fluid in patients with depressive illness, not infiltration of circulating cytokines. Searches for chronic stress, cytokines, mechanical trauma, and brain tumors found no passage addressing the attributed claim. (LLM, conf=0.76)
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Research works printed but not linked: 4
- Benda, P., Planiol, T., Tubiana, M., and Constans, J. (1954). Radioisotope Conference, ed. J. E. Johnston, Vol. 1, p. 161.
- Selverstone, B. (1958). In Ciba Foundation Symposium on the Cerebro- spinal Fluid: Production, Circulation and Absorption, ed.
- Walter, F. K. (1929). Die Blut-Liquorschranke. Thieme, Leipzig.
- Woodbury, D. M., Timiras, P. S., and Vernadakis, A. (1957). In Hormones, Brain Function, and Behavior, ed. H. Hoagland, p. 27. Academic Press, New York.
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Social stress induces neurovascular pathology promoting depression
Menard, C., Pfau, M. L., Hodes, G. E., Kana, V., Wang, V. X., Bouchard, S., Takahashi, A., Flanigan, M. E., Aleyasin, H., LeClair, K. B., et al. (2017) · Nature Neuroscience · doi:10.1038/s41593-017-0010-3 · Cited by 1,028 · see citing works
- Authors
- Coppen, A. J.
- Affiliations
- Maudsley Hospital (GB)
- Corresponding author
- Coppen, A. J.
- Venue
- Journal of Neurology, Neurosurgery & Psychiatry
- Publisher
- BMJ
- Published
- 1960-05-01
- Volume
- 23
- Issue
- 2
- Pages
- 156-161
- ISSN
- 0022-3050 (ISSN-L)
- PMC
- PMC495347
- OpenAlex
- W2157519583
- Cited by
- 77
- References
- 0
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 2 · 2022: 1 · 2021: 1 · 2020: 1 · 2019: 2 · 2017: 1
- FWCI
- 2.91
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Neurology Neurosurgery & Psychiatry (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Cerebrospinal fluid and hydrocephalus
- Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Keywords
- blood-CSF barrier, depressive disorders, depression, blood-CSF barrier permeability, cerebrospinal fluid
- MeSH terms
- Blood-Brain Barrier, Depression, Depressive Disorder, Humans
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