The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Clinical signs in the Wernicke-Korsakoff complex: a retrospective analysis of 131 cases diagnosed at necropsy.
Open accessAbstract
A recent necropsy study has shown that 80% of patients with the Wernicke-Korsakoff syndrome were not diagnosed as such during life. Review of the clinical signs of these cases revealed that only 16% had the classical clinical triad and 19% had no documented clinical signs. The incidence of clinical signs in this and other retrospective pathological studies is very different from that of prospective clinical studies. This discrepancy may relate to "missed" clinical signs but the magnitude of the difference suggests that at least some cases of the Wernicke-Korsakoff syndrome may be the end result of repeated subclinical episodes of vitamin B1 deficiency. In order to make the diagnosis, clinicians must maintain a high index of suspicion in the "at risk" group of patients, particularly alcoholics. Investigations of thiamine status may be helpful and if the diagnosis is suspected, parenteral thiamine should be given.
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Cites
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The incidence of Wernicke's encephalopathy in Australia--a neuropathological study of 131 cases.
Harper, C. (1983) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.46.7.593 · Cited by 337
Self-citationCEREBRAL DISORDER IN ALCOHOLISM SYNDROMES OF IMPAIRMENT
LISHMAN, W. A. (1981) · Brain · doi:10.1093/brain/104.1.1 · Cited by 211
Principles of internal medicine
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Ackerman, W. J. (1974) · PubMed · Cited by 33
Cited by
Caine, D., Halliday, G. M., Kril, J. J., & Harper, C. G. (1997) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.62.1.51 · Cited by 489
Self-citationNeurocognitive impairment associated with alcohol use disorders: Implications for treatment.
Bates, M. E., Bowden, S. C., & Barry, D. (2002) · Experimental and Clinical Psychopharmacology · doi:10.1037/1064-1297.10.3.193 · Cited by 406
Thomson, A. D. (2002) · Alcohol and Alcoholism · doi:10.1093/alcalc/37.6.513 · Cited by 396
Wernicke-Korsakoff-syndrome: Under-recognized and under-treated
Isenberg-Grzeda, E., Kutner, H. E., & Nicolson, S. E. (2012) · Psychosomatics · doi:10.1016/j.psym.2012.04.008 · Cited by 253
Thiamine for prevention and treatment of Wernicke-Korsakoff Syndrome in people who abuse alcohol
Day, E., Bentham, P. W., Callaghan, R., Kuruvilla, T., & George, S. (2013) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd004033.pub3 · Cited by 158
Metadata
- Authors
- Harper, C. G., Giles, M., & Finlay-Jones, R.
- Venue
- Journal of Neurology, Neurosurgery & Psychiatry
- Publisher
- BMJ
- Published
- 1986-04-01
- Volume
- 49
- Issue
- 4
- Pages
- 341-345
- ISSN
- 0022-3050 (ISSN-L)
- OpenAlex
- W2105505685
- Cited by
- 657
- References
- 9
- FWCI
- 6.11
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Clinical signs in the Wernicke-Korsakoff complex: a retrospective analysis of 131 cases diagnosed at necropsy. https://app.cochat.ai/papers/10.1136/jnnp.49.4.341
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- Harper, C. G., Giles, M., & Finlay-Jones, R. (1986). Clinical signs in the Wernicke-Korsakoff complex: a retrospective analysis of 131 cases diagnosed at necropsy. Journal of Neurology, Neurosurgery & Psychiatry. https://doi.org/10.1136/jnnp.49.4.341
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
