The DOI matches its Crossref record; 32 of the 33 references it cites were found in a registry or an index, and 1 are not checked yet.
Amelioration of osteopenia and hypovitaminosis D by 1alpha -hydroxyvitamin D3 in elderly patients with Parkinson's disease
Open accessAbstract
OBJECTIVES: A high prevalence of hip and other fractures in elderly patients with Parkinson's disease has been linked to reduced bone mass arising from a defect of renal synthesis of 1, 25-dihydroxyvitamin D (1, 25-[OH]2D). Treatment with 1alpha-hydroxyvitamin D3 (1alpha(OH)D3; an active form of vitamin D) was evaluated for maintaining bone mass and reducing the incidence of hip and other nonvertebral fractures in patients with Parkinson's disease. METHODS: In a double blind, randomised trial, 86 elderly patients with Parkinson's disease (mean Hoehn and Yahr stage, 3; mean age 70.6 years) were randomised to receive either 1 microg 1alpha(OH)D3 daily (treatment group, n=43) or a placebo (n=43) for 18 months. Bone mineral densities in the second metacarpals were determined by computed radiographic densitometry. Serum bone turnover indices were measured serially, and incidence of nonvertebral fractures was recorded. RESULTS: Bone mineral densities decreased 1.2% in the treatment group compared with 6.7% in the placebo group during 18 months (p<0.0001). At baseline in both groups, the serum concentration of 1, 25-[OH]2D was reduced. Parathyroid hormone was abnormally increased in 15 patients (17%) and correlated negatively with serum 25-hydroxyvitamin D, indicating compensatory hyperparathyroidism. Eight patients sustained fractures (six at the hip and two at other sites) in the placebo group, and one hip fracture occurred among treated patients (odds ratio 9.8; p=0.0028). CONCLUSION: By increasing serum 1, 25-[OH]2D concentrations, treatment with 1alpha(OH)D3 can reduce the risk of hip and other non-vertebral fractures in osteoporotic elderly patients with Parkinson's disease by slowing the loss of bone mineral densities.
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“Three affected trial reports8 15 16 were cited in the review by Binks and Dobson34 (one citation, 2017) as evidence for the benefit of vitamin D and bisphosphonates in people with Parkinson’s disease.”
From An investigation into the impact and implications of published papers from retracted research: systematic search of affected literature (2019) · cites this paper as [8]
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“In their review of vitamin D and Parkinson’s disease, Peterson et al 33 (16 citations, 2017) base their conclusions almost entirely on data from four affected trial reports.8 9 15 16”
From An investigation into the impact and implications of published papers from retracted research: systematic search of affected literature (2019) · cites this paper as [8]
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“A guideline from AHRQ57 excluded one trial report8 from its review of interventions to prevent falls in older people. The reason for exclusion was that the report did not focus on the outcome of interest, that is, the rate of falls or number of fallers, despite what appeared to be relevant falls data in the affected trial report.”
From An investigation into the impact and implications of published papers from retracted research: systematic search of affected literature (2019) · cites this paper as [8]
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Citations
Cites
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Sorted by citations
Interventions for preventing falls in older people living in the community
Gillespie, L. D., Robertson, M. C., Gillespie, W. J., Sherrington, C., Gates, S., Clemson, L., & Lamb, S. E. (2012) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd007146.pub3 · Cited by 3,966
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Interventions for preventing falls in older people living in the community
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Metadata
- Authors
- Sato, Y., Manabe, S., Kuno, H., & Oizumi, K.
- Affiliations
- Kurume University (JP)
- ORCID
- Manabe, S.
- Venue
- Journal of Neurology, Neurosurgery & Psychiatry
- Publisher
- BMJ
- Published
- 1999-01-01
- Volume
- 66
- Issue
- 1
- Pages
- 64-68
- ISSN
- 0022-3050 (ISSN-L)
- PMC
- PMC1736147
- OpenAlex
- W2082859231
- Cited by
- 131
- References
- 33
- Citations by year
- 2025: 2 · 2024: 1 · 2023: 3 · 2022: 3 · 2020: 1 · 2019: 5 · 2018: 2 · 2017: 3 · 2016: 4 · 2015: 2 · 2014: 3 · 2013: 11 · 2012: 4
- FWCI
- 2.33
- Type
- journal article
- Language
- en
- Status
- Retracted
- Update notices
- retraction (2017-08-28)
- Open access
- bronze
- doi.org
- Locations
- Journal of Neurology Neurosurgery & Psychiatry (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Vitamin D Research Studies
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
- Health Sciences › Medicine › Nephrology › Parathyroid Disorders and Treatments
- Keywords
- Parkinson's disease, 1α-hydroxyvitamin D3, 1,25-dihydroxyvitamin D, osteopenia, vitamin D deficiency, bone mineral density, hip fracture, non-vertebral fractures, osteoporosis, older adults, parathyroid hormone, bone turnover
- MeSH terms
- Aged, Aged, 80 and over, Bone Diseases, Metabolic, Double-Blind Method, Female, Hip Fractures, Humans, Hydroxycholecalciferols, Male, Parathyroid Hormone, Parkinson Disease, Vitamin D Deficiency, Bone Density
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