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Alzheimer's disease comorbidity in normal pressure hydrocephalus: prevalence and shunt response
Open accessAbstract
The clinical impact of Alzheimer's disease pathology at biopsy was investigated in 56 cognitively impaired patients undergoing shunt surgery for idiopathic normal pressure hydrocephalus (NPH). Cognition was measured by means of the global deterioration scale (GDS), the mini mental status examination (MMSE) and a battery of six psychometric tests. Gait was assessed using objective measurements of velocity and the ambulatory index (AI). The prevalence of cases exhibiting neuritic plaques (positive biopsies) increased in parallel with dementia severity from 18% for patients with GDS 3 to 75% for patients with GDS scores > or =6. Patients with positive biopsies were more cognitively impaired (higher GDS and lower MMSE scores) as well as more gait impaired (higher AI scores and slower velocities) than patients with negative biopsies. After surgery, gait velocity and AI scores improved significantly and to a comparable degree for patients with and without positive biopsies. Similar proportions of positive and negative biopsy patients also had improved gait as assessed by means of subjective video tape comparisons. There were no significant differences between the biopsy groups in the magnitude of postoperative psychometric change or in the proportion of cases exhibiting improved urinary control. Alzheimer's disease pathology is a common source of comorbidity in older patients with idiopathic NPH where it contributes to the clinical impairment associated with this disorder. For patients accurately diagnosed with NPH, concomitant Alzheimer's disease pathology does not strongly influence the clinical response to shunt surgery.
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“There is large overlap of typical findings in brain specimens of patients with Alzheimer's disease and iNPH (68).”
From Brain-wide glymphatic enhancement and clearance in humans assessed with MRI. (2018) · cites this paper as [68]
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VALIDITY OF THE TRAIL MAKING TEST AS AN INDICATOR OF ORGANIC BRAIN DAMAGE
Reitan, R. M. (1958) · Perceptual and Motor Skills · doi:10.2466/pms.1958.8.3.271 · Cited by 8,167
The Global Deterioration Scale for assessment of primary degenerative dementia
Reisberg, ., Ferris, S. H., de Leon, M. J., & Crook, T. H. (1982) · American Journal of Psychiatry · doi:10.1176/ajp.139.9.1136 · Cited by 5,122
Mirra, S. S., Heyman, A., McKeel, D., Sumi, S. M., Crain, B. J., Brownlee, L. M., Vogel, F. S., Hughes, J. P., Belle, G. V., Berg, L., et al. (1991) · Neurology · doi:10.1212/wnl.41.4.479 · Cited by 4,961
Consortium to Establish a Registry for Alzheimer's Disease (CERAD)
Fillenbaum, G., & Heyman, A. (2002) · doi:10.1002/0470846410.ch42(iii · Cited by 2,859
Wechsler Adult Intelligence Scale
(2007) · Sage eBooks · doi:10.4135/9781412952644.n478 · Cited by 2,017
The Purdue Pegboard: norms and studies of reliability and validity.
Tiffin, J. H., & Asher, E. J. (1948) · Journal of Applied Psychology · doi:10.1037/h0061266 · Cited by 1,247
Intensive Immunosuppression in Progressive Multiple Sclerosis
Hauser, S. L., Dawson, D. M., Lehrich, J. R., Beal, M. F., Kevy, S. V., Propper, R. D., Mills, J. L., & Weiner, H. L. (1983) · New England Journal of Medicine · doi:10.1056/nejm198301273080401 · Cited by 829
Pattern of brain destruction in Parkinson's and Alzheimer's diseases
Braak, H., Braak, E., Yilmazer‐Hanke, D., de Vos, R. A. I., Jansen, E. N. H., & Böhl, J. (1996) · Journal of Neural Transmission · doi:10.1007/bf01276421 · Cited by 326
GAIT AND BALANCE IN SENILE DEMENTIA OF ALZHEIMER'S TYPE
VISSER, H. (1983) · Age and Ageing · doi:10.1093/ageing/12.4.296 · Cited by 168
Savolainen, S., Paljärvi, L., & Vapalahti, M. P. (1999) · Acta Neurochirurgica · doi:10.1007/s007010050386 · Cited by 155
REPETITIVE PSYCHOMETRIC MEASURES
Moran, L. J., & Mefferd, R. B. (1959) · Psychological Reports · doi:10.2466/pr0.1959.5.3.269 · Cited by 103
A Preliminary Report on a New Memory Scale
Gilbert, J. G., Levee, R. F., & Catalano, F. L. (1968) · Perceptual and Motor Skills · doi:10.2466/pms.1968.27.1.277 · Cited by 100
Bech‐Azeddine, R., Juhler, M., Waldemar, G., Klinken, L., & Gjerris, F. (1997) · Neurosurgery · doi:10.1097/00006123-199703000-00013 · Cited by 97
Golomb, J. B., de Leon, M. J., GEORGE, A. E., Kluger, A., Convit, A. J., Rusinek, H., Santi, S. D., Litt, A. W., Foo, S. H., & Ferris, S. H. (1994) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.57.5.590 · Cited by 85
Self-citationNeuropathological Changes in Chronic Adult Hydrocephalus: Cortical Biopsies and Autopsy Findings
Bigio, M. R. D., Cardoso, E. R., & HALLIDAY, W. C. (1997) · Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques · doi:10.1017/s0317167100021442 · Cited by 75
Price (1999) · doi:10.1002/1531-8249(199903)45:3
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Anatomy and physiology of cerebrospinal fluid
Sakka, L. J., Coll, G., & Chazal, J. (2011) · European Annals of Otorhinolaryngology Head and Neck Diseases · doi:10.1016/j.anorl.2011.03.002 · Cited by 816
Guidelines for Management of Idiopathic Normal Pressure Hydrocephalus: Second Edition
Mori, E., Ishikawa, M., Kato, T., Kazui, H., Miyake, H., Miyajima, M., Nakajima, M., Hashimoto, M., Kuriyama, N., Tokuda, T., et al. (2012) · Neurologia medico-chirurgica · doi:10.2176/nmc.52.775 · Cited by 666
Brain-wide glymphatic enhancement and clearance in humans assessed with MRI.
Ringstad, G., Valnes, L. M., Dale, A. M., Pripp, A. H., Vatnehol, S.-A. S., Emblem, K. E., Mardal, K.-A., & Eide, P. K. (2018) · JCI Insight · doi:10.1172/jci.insight.121537 · Cited by 533
“There is large overlap of typical findings in brain specimens of patients with Alzheimer’s disease and iNPH (68).”
Silverberg, G. D., Mayo, M. R., Saul, T., Rubenstein, E., & McGuire, D. (2003) · The Lancet Neurology · doi:10.1016/s1474-4422(03)00487-3 · Cited by 433
Glymphatic System Impairment in Alzheimer’s Disease and Idiopathic Normal Pressure Hydrocephalus
Reeves, B. C., Karimy, J. K., Kundishora, A. J., Mestre, H., Cerci, H. M., Matouk, C., Alper, S. L., Lundgaard, I., Nedergaard, M., & Kahle, K. T. (2020) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2019.11.008 · Cited by 412
Metadata
- Authors
- Golomb, J.
- Affiliations
- New York University (US)
- Corresponding author
- Golomb, J
- ORCID
- Golomb, J
- Venue
- Journal of Neurology, Neurosurgery & Psychiatry
- Publisher
- BMJ
- Published
- 2000-06-01
- Volume
- 68
- Issue
- 6
- Pages
- 778-781
- ISSN
- 0022-3050 (ISSN-L)
- PMC
- PMC1736969
- OpenAlex
- W2120054797
- Cited by
- 279
- References
- 17
- Citations by year
- 2026: 7 · 2025: 13 · 2024: 10 · 2023: 13 · 2022: 12 · 2021: 13 · 2020: 16 · 2019: 16 · 2018: 17 · 2017: 17 · 2016: 13 · 2015: 12 · 2014: 13 · 2013: 6 · 2012: 16
- FWCI
- 1.55
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Neurology Neurosurgery & Psychiatry (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Clinical Neurology › Cerebrospinal fluid and hydrocephalus
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Keywords
- Alzheimer's disease, normal pressure hydrocephalus, comorbidities, shunt surgery, neuritic plaques, dementia severity, gait disturbance, urinary incontinence, cognitive function, postoperative outcomes
- MeSH terms
- Aged, Aged, 80 and over, Alzheimer Disease, Biopsy, Cerebral Cortex, Female, Follow-Up Studies, Humans, Hydrocephalus, Normal Pressure, Male, Postoperative Complications, Comorbidity, Ventriculoperitoneal Shunt, Plaque, Amyloid
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