Cited by 327Health Systems, Economic Evaluations, Quality of LifeParkinson's Disease Mechanisms and TreatmentsDeep Brain Stimulation and Movement Disorders

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The EQ-5D---a generic quality of life measure---is a useful instrument to measure quality of life in patients with Parkinson's disease

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Schrag, A.·2000·Journal of Neurology, Neurosurgery & Psychiatry

DOI 10.1136/jnnp.69.1.67PMC PMC1737007

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Abstract

OBJECTIVE: To test the feasibility and validity of the EQ-5D (a widely used generic (disease non-specific) quality of life (QoL) instrument which allows comparisons between different patient groups and the general population) to assess QoL in patients with Parkinson's disease. METHODS: All 124 patients with Parkinson's disease seen in a community based study on the prevalence of parkinsonism were asked to complete a QoL battery comprising the EQ-5D, the medical outcome study short form (SF-36), the PDQ-39, a disease specific instrument to assess QoL in PD, and the Beck depression inventory. A structured questionnaire interview and a complete neurological examination including the Hoehn and Yahr stage of illness scale, the Schwab and England disability scale, the motor section of the unified Parkinson's disease rating scale (UPDRS), and the mini mental state examination (MMSE) were performed on the same day. RESULTS: The response rate was 78% and the completion rate of the EQ-5D among responders was 96%. The EQ-5D summary index correlated strongly with the PDQ-39 (r=-0.75, p<0.0001) as well as the physical score of the SF-36 (r=0.61, p<0.0001). There was a significant correlation of the EQ-5D summary index with disease severity, as measured by the Hoehn and Yahr stage of illness, the Schwab and England disability scale, the motor section of the UPDRS, and the depression score. The EQ-5D summary index also distinguished between patients with and without depression, falls, postural instability, cognitive impairment hallucinations, and those with deterioration of health over the previous year. CONCLUSION: The EQ-5D is a feasible and valid instrument to measure QoL in Parkinson's disease and reflects the severity and complications of the disease.

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Authors: Schrag, A.
Affiliations: National Hospital for Neurology and Neurosurgery (GB)
Corresponding author: Schrag, A.
ORCID: Schrag, A.
Venue: Journal of Neurology, Neurosurgery & Psychiatry
Publisher: BMJ
Published: 2000-07-01
Volume: 69
Issue: 1
Pages: 67-73
ISSN: 0022-3050 (ISSN-L)
DOI: 10.1136/jnnp.69.1.67
PMC: PMC1737007
OpenAlex: W2135640360
Cited by: 327
References: 37
Citations by year: 2026: 10 · 2025: 5 · 2024: 8 · 2023: 11 · 2022: 16 · 2021: 13 · 2020: 13 · 2019: 12 · 2018: 10 · 2017: 14 · 2016: 8 · 2015: 17 · 2014: 19 · 2013: 23 · 2012: 12
FWCI: 19.84
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Journal of Neurology Neurosurgery & Psychiatry (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
UCL Discovery (University College London) (submittedVersion)
Topics: Social Sciences › Economics, Econometrics and Finance › Economics and Econometrics › Health Systems, Economic Evaluations, Quality of Life
Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
Health Sciences › Medicine › Clinical Neurology › Deep Brain Stimulation and Movement Disorders
Keywords: EQ-5D, Parkinson's disease, quality of life, assessment validity, PDQ-39, SF-36, depression, disease severity, disability, falls, postural instability, cognitive impairment, hallucinations
MeSH terms: Activities of Daily Living, Adult, Aged, Aged, 80 and over, Feasibility Studies, Female, Humans, Male, Mental Status Schedule, Middle Aged, Parkinson Disease, Quality of Life, Sick Role, Reproducibility of Results, Sickness Impact Profile

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The EQ-5D---a generic quality of life measure---is a useful instrument to measure quality of life in patients with Parkinson's disease

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