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Aquaporin-4 expression is increased in oedematous human brain tumours
Open accessAbstract
Aquaporin-4 (AQP4) is a highly conserved water channel protein. In rats, AQP4 is expressed in astrocyte foot processes and is important in brain water homeostasis. AQP4 expression has not been investigated in non-neoplastic human brain or oedematous brain tumours, where water homeostasis is disrupted. Therefore, immunohistochemistry was used to study AQP4 expression in non-neoplastic and neoplastic human brain and blood-brain barrier permeability was assessed using contrast enhanced computed tomograms. AQP4 was present around microvessels in five specimens of non-neoplastic brain and five low grade (Daumas-Duport I or II) astrocytomas. AQP4 was massively upregulated in four and absent in one high grade (Daumas-Duport III or IV) astrocytoma. Massive upregulation of AQP4 was also found in reactive astrocytes in five metastatic adenocarcinomas. There was significant (p<0.0001) correlation between blood-brain barrier opening and upregulated AQP4 expression. Increased AQP4 expression in high grade astrocytomas and adenocarcinomas may facilitate the flow of oedema fluid.
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Cited by
IgG marker of optic-spinal multiple sclerosis binds to the aquaporin-4 water channel
Lennon, V. A., Kryzer, T. J., Pittock, S. J., Verkman, A. S., & Hinson, S. R. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20050304 · Cited by 2,288
A blood–brain barrier overview on structure, function, impairment, and biomarkers of integrity
Kadry, H., Noorani, B., & Cucullo, L. (2020) · Fluids and Barriers of the CNS · doi:10.1186/s12987-020-00230-3 · Cited by 1,853
Unterberg, A. W., Stover, J., Kress, B., & Kiening, K. L. (2004) · Neuroscience · doi:10.1016/j.neuroscience.2004.06.046 · Cited by 881
Physiological Roles of Aquaporin-4 in Brain
Nagelhus, E. A., & Ottersen, O. P. (2013) · Physiological Reviews · doi:10.1152/physrev.00011.2013 · Cited by 766
The molecular basis of water transport in the brain
Amiry-Moghaddam, M., & Ottersen, O. P. (2003) · Nature Reviews Neuroscience · doi:10.1038/nrn1252 · Cited by 733
Metadata
- Authors
- Saadoun, S.
- Venue
- Journal of Neurology, Neurosurgery & Psychiatry
- Publisher
- BMJ
- Published
- 2002-02-01
- Volume
- 72
- Issue
- 2
- Pages
- 262-265
- ISSN
- 0022-3050 (ISSN-L)
- OpenAlex
- W2156403214
- Cited by
- 376
- References
- 0
- FWCI
- 5.83
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Saadoun, S. (2002). Aquaporin-4 expression is increased in oedematous human brain tumours. Journal of Neurology, Neurosurgery & Psychiatry. https://doi.org/10.1136/jnnp.72.2.262
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