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Inflammation generating potential of long and short fibre amosite asbestos samples.
Abstract
Previous studies have shown that long thin asbestos fibres are more pathogenic in in vivo and more active in in vitro assays than short fibre samples. In the present study a long fibre amosite asbestos sample and a short fibre sample prepared from it were tested for ability to cause inflammation in the peritoneal cavity of the mouse; a UICC sample intermediate in fibre size and an inert compact dust, TiO2, were also tested. The ability of the dust samples to cause inflammation, as judged by macrophage and neutrophil recruitment, was ranked in the order long fibre greater than UICC greater than short fibre greater than TiO2. Ability of amosite samples to cause inflammation was therefore related to the proportion of long fibres. The enhanced ability of long fibres to cause inflammation and cause macrophage activation is probably a key factor in the ability of long fibres to cause pulmonary fibrosis and may also be important in fibre carcinogenesis.
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“These studies showed that LAF induced marked local inflammatory reactions, compared to SAF, with activation of macrophages, increased extracellular production of cytokine and ROS (Reactive Oxygen Species), as well as immunosuppression.”
From Quantification of short and long asbestos fibers to assess asbestos exposure: A review of fiber size toxicity (2014) · cites this paper as [78]
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“Although the intraperitoneal administration of a single dose of SAF did not seem to have a great impact on local inflammation in mice, repetitive exposures increased the inflammatory reactions.”
From Quantification of short and long asbestos fibers to assess asbestos exposure: A review of fiber size toxicity (2014) · cites this paper as [78]
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“For this study, it is important to note that the LAF and SAF were injected in equal numbers, corresponding to 480 μg and 120 μg respectively.”
From Quantification of short and long asbestos fibers to assess asbestos exposure: A review of fiber size toxicity (2014) · cites this paper as [78]
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Research works printed but not linked: 26
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- The Br J Ind Med, together with many other international biomedical journals, has agreed to accept articles prepared in accordance with the Vancouver style. The style (described in full in Br Med J, 24 February 1979, p 532) is intended to standardise requirements for authors.
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Cited by
Poland, C. A., Duffin, R., Kinloch, I., Maynard, A., Wallace, W. A. H., Seaton, A., Stone, V., Brown, S., MacNee, W., & Donaldson, K. (2008) · Nature Nanotechnology · doi:10.1038/nnano.2008.111 · Cited by 2,645
Self-citationDonaldson, K., Aitken, R., Tran, L., Stone, V., Duffin, R., Forrest, G., & Alexander, A. (2006) · Toxicological Sciences · doi:10.1093/toxsci/kfj130 · Cited by 1,167
Self-citationMechanisms in the Pathogenesis of Asbestosis and Silicosis
MOSSMAN, B. T., & CHURG, A. (1998) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.157.5.9707141 · Cited by 971
Donaldson, K., Murphy, F. A., Duffin, R., & Poland, C. A. (2010) · Particle and Fibre Toxicology · doi:10.1186/1743-8977-7-5 · Cited by 916
Self-citationNagai, H., Okazaki, Y., Chew, S. H., Misawa, N., Yamashita, Y., Akatsuka, S., Ishihara, T., Yamashita, K., Yoshikawa, Y., Yasui, H., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1110013108 · Cited by 535
Metadata
- Authors
- Donaldson, K., Brown, G. M., Brown, D. M., Bolton, R. E., & Davis, J. M.
- Venue
- Occupational and Environmental Medicine
- Publisher
- BMJ
- Published
- 1989-04-01
- Volume
- 46
- Issue
- 4
- Pages
- 271-276
- ISSN
- 1351-0711
- Cited by
- 12
- References
- 0
- Language
- en
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- Donaldson, K., Brown, G. M., Brown, D. M., Bolton, R. E., & Davis, J. M. (1989). Inflammation generating potential of long and short fibre amosite asbestos samples. Occupational and Environmental Medicine. https://doi.org/10.1136/oem.46.4.271
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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