Some Observations on Diabetes and Insulin in General Practice
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Once insulin therapy was available, clinicians related differences to insulin requirements, with insulin-insensitive patients usually presenting later in life, with obesity and a more insidious presentation.
“Once insulin therapy was available, clinicians related these differences to insulin requirements, with insulin-insensitive patients usually presenting with symptoms later in life, in association with obesity and a more insidious presentation20,21.”
From 100 years of insulin: celebrating the past, present and future of diabetes therapy (2021) · cites this paper as [21]
In 'DIETETIC OR INSULIN TREATMENT ?' (page unavailable), MacLean contrasts young patients with true diabetes, for whom insulin is usually necessary, with patients who are 'usually too fat.' The 'INSULIN TREATMENT' section says insulin is usually unnecessary for hepatic glycosuria in middle or old age. But the paper does not describe these patients as insulin-insensitive or say their symptoms present insidiously; it explicitly distinguishes hepatic glycosuria from true diabetes. (LLM, conf=0.85)
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100 years of insulin: celebrating the past, present and future of diabetes therapy
Sims, E. K., Carr, A. L. J., Oram, R. A., DiMeglio, L. A., & Evans-Molina, C. (2021) · Nature Medicine · doi:10.1038/s41591-021-01418-2 · Cited by 270 · see citing works
- Authors
- MacLean, H.
- Affiliations
- University of London (GB)
- Corresponding author
- MacLean, Hugh
- Venue
- Postgraduate Medical Journal
- Publisher
- Oxford University Press (OUP)
- Published
- 1926-03-01
- Volume
- 1
- Issue
- 6
- Pages
- 73-77
- ISSN
- 0032-5473 (ISSN-L)
- 1469-0756
- PMC
- PMC2531338
- OpenAlex
- W1983952542
- Cited by
- 10
- References
- 0
- Citations by year
- 2025: 1 · 2023: 3 · 2021: 1 · 2020: 1 · 2019: 1 · 2015: 2
- FWCI
- 0.00
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Postgraduate Medical Journal (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- HighWire Press Open Archive (submittedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Education
- Keywords
- diabetes mellitus, insulin therapy, general practice
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