A new look at erythromycin
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Summary: This article reviews the current place of erythromycin in antibiotic therapy. Overall, erythromycin is thought to be underused because: (1) the fear of resistance has been exaggerated; (2) significant toxicity has been associated with only one derivative (the estolate); (3) newer antibiotics have very rarely been demonstrated to be superior to erythromycin. Erythromycin has an important place in treating acute upper and lower respiratory tract infections, acute otitis media, sinusitis, skin and soft tissue, osteomyelitis, prostatitis, infections due to Mycoplasma spp. and Chlamydia organisms, and infections due to anaerobes.
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In healthy volunteers, clomipramine nights had significantly less REM% than placebo (REM almost totally suppressed with clomipramine).
“CLO nights sig less REM% (p<.001) than PLC (REM almost totally suppressed with CLO)”
From Antidepressants and their effect on sleep (2005) · cites this paper as Lacey, 1977
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- BLOCKEY, N.J. & MCALLISTER, T.A. (1972) Antibiotics in acute osteomyelitis in children. Journal of Bone and Joint Surgery, 54B, 299. · DOI
- BURGESS, H.A. & EVANS, K.J. (1966) Failure of cephaloridine in a case of staphylococcal endocarditis. British Medical Journal, 3, 1244. · DOI
- GARROD, L.P., LAMBERT, H.P. & O'GRADY, F. (1973) Antibiotic and Chemotherapy, pp. 173-174. Churchill Livingstone, Edinburgh and London.
- GOULD, J.C. (1975) Erythromycin and resistance transfer factors in the intestinal tract. In: Drug Inactivating Enzymes and Antibiotic Resistance, pp. 259-263. Avicenum, Prague. · DOI
- KALM, O., KAMME, C., BERGSTROM, B., LUFKIST, T. & NORMAN, 0. (1976) Erythromycin stearate in acute maxillary sinusitis. Scandinavian Journal of Infectious Diseases, 7, 209.
- LACEY, R.W. (1973) Genetic basis, epidemiology and future significance of antibiotic resistance in Staphylococcus aureus. Journal of Clinical Pathology, 26, 899. · DOI
- LACEY, R.W. & LEWIS, E.L. (1976) Inactivation of'penicillinase-resistant' penicillins and cephalosporins by staphylococcal penicillinase; clinical and laboratory studies. In: Third International Symposium on Staphylococci and Staphylococcal Diseases. Fischer Verlag, Stuttgart.
- LEADING ARTICLE (1975) Antibiotic diarrhoea. British Medical Journal, 4, 243. · DOI
- MALMBORG, A., DORNBUSCH, K., ELIASSON, R. & LINDHOLMER, C. (1976) Concentration of antibacterials in human seminal plasma. In: Proceedings, Ninth International Congress of Chemotherapy, July 1975. MANNERS, T.B., GROB, P.R., BENYON, G.P.J. & GIBBS, F.J. (1976) An investigation of antibiotic resistance of Staphylococcus aureus in general practice. Practitioner, 216, 439.
- MASKELL, R., OKUBADEJO, O.A. & PAYNE, R.H. (1976) Thymine-requiring bacteria associated with co-trimoxazole therapy. Lancet, i, 834.
- MAY, J.R. (1973) Antibiotics used in sequence in the treatment of chronic Haemophilus influenzae respiratory infections. In: Clinical Use of Combinations of Antibiotics. Hodder and Stoughton, London. ORIEL, J.D., REEVE, P., WRIGHT, J. & OWEN, J.M. (1976) Chlamydial infections of the male urethra. British Journal of Venereal Disease, 52, 46.
- PEACH, S. (1975) Antibiotic-disc tests for rapid identification of non-sporing anaerobes. Journal of Clinical Pathology, 28, 388. · DOI
- RIDGEWAY, G.L., OWEN, J.M. & ORIEL, J.D. (1976) A method of testing the antibiotic susceptibility of Chlamydia trachomatis in a cell culture system. Journal of Antimicrobial Chemotherapy, 2, 71. · DOI
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Antidepressants and their effect on sleep
Mayers, A. G., & Baldwin, D. S. (2005) · Human Psychopharmacology: Clinical and Experimental · doi:10.1002/hup.726 · Cited by 323 · see citing works
- Authors
- Lacey, R. W.
- Affiliations
- North Cambridgeshire Hospital (GB)
- Corresponding author
- Lacey, R W
- Venue
- Postgraduate Medical Journal
- Publisher
- Oxford University Press (OUP)
- Published
- 1977-04-01
- Volume
- 53
- Issue
- 618
- Pages
- 195-200
- ISSN
- 0032-5473 (ISSN-L)
- 1469-0756
- PMC
- PMC2496485
- OpenAlex
- W1977334509
- Cited by
- 23
- References
- 0
- Citations by year
- 2020: 1 · 2012: 1
- FWCI
- 2.26
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Postgraduate Medical Journal (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pharmacology (medical) › Antibiotics Pharmacokinetics and Efficacy
- Health Sciences › Medicine › Infectious Diseases › Antibiotic Use and Resistance
- Health Sciences › Medicine › Epidemiology › Pneumonia and Respiratory Infections
- Keywords
- erythromycin, antibiotic therapy, antibiotic resistance, respiratory infections, otitis media, sinusitis, skin and soft tissue infections, osteomyelitis, prostatitis, mycoplasma infection, chlamydia, anaerobic infections
- MeSH terms
- Bacterial Infections, Drug Resistance, Microbial, Erythromycin, Female, Humans, Male, Osteomyelitis, Respiratory Tract Infections, Skin Diseases, Infectious, Urologic Diseases
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