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Long-term treatment of trigeminal neuralgia with carbamazepine
Open accessAbstract
Summary: The results of treating 143 patients with trigeminal neuralgia with carbamazepine (CBZ) over a 16-year period have been reviewed. The drug was effective initially with few mild side effects in 99 patients (69%). Of these, 19 developed resistance later, i.e. between 2 months and 10 years after commencing treatment, and required alternative measures. Of the remaining 80 (56%), the drug was effective in 49 for 1-4 years and in 31 for 5-16 years. Thirty-six patients (25%) failed to respond to CBZ initially and required alternative measures, as did 8 (6%) who were intolerant of the drug. One patient developed CBZ-induced water intoxication with hyponatraemia. Subsequently hyponatraemia was excluded in 17 patients who had been taking CBZ for between 4 months and 7 years. This study has thus confirmed the efficacy of CBZ in the treatment of trigeminal neuralgia and shown that it may continue to be effective for many years.
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Citations
Cited by
European Academy of Neurology guideline on trigeminal neuralgia
Bendtsen, L., Zakrzewska, J. M., Abbott, J., Braschinsky, M., Di Stefano, G., Donnet, A., Eide, P. K., Leal, P. R. L., Maarbjerg, S., May, A., et al. (2019) · European Journal of Neurology · doi:10.1111/ene.13950 · Cited by 668
Trigeminal neuralgia—pathophysiology, diagnosis and current treatment
Nurmikko, T. J., & Eldridge, P. R. (2001) · British Journal of Anaesthesia · doi:10.1093/bja/87.1.117 · Cited by 417
(1988) · doi:10.1001/archneur.1989.00520450030015 · Cited by 173
Murugesan, I., T.N., U., & Ramalingam, K. (2024) · Cureus · doi:10.7759/cureus.69258 · Cited by 6
Metadata
- Authors
- Taylor, J. C., Brauer, S., & Espir, M. L. E.
- Venue
- Postgraduate Medical Journal
- Publisher
- Oxford University Press (OUP)
- Published
- 1981-01-01
- Volume
- 57
- Issue
- 663
- Pages
- 16-18
- ISSN
- 0032-5473 (ISSN-L)
- 1469-0756
- OpenAlex
- W1979976727
- Cited by
- 258
- References
- 0
- FWCI
- 1.15
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Long-term treatment of trigeminal neuralgia with carbamazepine. https://app.cochat.ai/papers/10.1136/pgmj.57.663.16
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- Taylor, J. C., Brauer, S., & Espir, M. L. E. (1981). Long-term treatment of trigeminal neuralgia with carbamazepine. Postgraduate Medical Journal. https://doi.org/10.1136/pgmj.57.663.16
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
