Hyperthyroidism during pregnancy due to coexistence of struma ovarii and Graves' disease
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Summary: A patient with hyperthyroid Graves' disease and struma ovarii is described. She had pre-existing Graves' disease and positive thyrotrophin receptor antibody. She was treated with radioactive iodine 5 months before she became pregnant. Paripartum she had torsion of an ovarian cyst with histological evidence of a functional struma ovarii. Immediate exacerbation of her thyrotoxic state was observed after operation as a result of release of thyroid hormone from the tumour. It is postulated that the tumour was stimulated by circulating thyrotrophin receptor antibody.
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Patients previously treated for GD may have persistent or recurrent hyperthyroidism due to the action of TRAb on the ectopic thyroid tissue.
“Patients previously treated for GD may have persistent or recurrent hyperthyroidism due to the action of TRAb on the ectopic thyroid tissue (663).”
From 2016 American Thyroid Association Guidelines for Diagnosis and Management of Hyperthyroidism and Other Causes of Thyrotoxicosis (2016) · cites this paper as [663]
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References 9 · Cited by 36
Research works printed but not linked: 2
- Bortolozzi, G. Lo struma ovarico presentazione di 5 casi e rassegna della letteratura. Annali din Obstetricia e Ginecologia 1967, 89: 310-331.
- Lefort, G., Commenges-Ducos, M., Denechaud, M., Rivel, J. & Latapie, J. Goitre ovarien au cours d'une maladie Basedow. La Nouvelle Presse Medicale 1981, 10: 2209-2210.
- Authors
- Kung, A. W. C., Ma, J. T. C., Wang, C., & Young, R. T.
- Affiliations
- Queen Mary Hospital (CN)
- Corresponding author
- Kung, A W C
- Venue
- Postgraduate Medical Journal
- Publisher
- Oxford University Press (OUP)
- Published
- 1990-02-01
- Volume
- 66
- Issue
- 772
- Pages
- 132-133
- ISSN
- 0032-5473 (ISSN-L)
- 1469-0756
- PMC
- PMC2429546
- OpenAlex
- W1977569140
- Cited by
- 36
- References
- 9
- Citations by year
- 2025: 1 · 2024: 2 · 2022: 1 · 2021: 1 · 2019: 1 · 2018: 1 · 2016: 2 · 2015: 1 · 2013: 2 · 2012: 2
- FWCI
- 0.31
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Postgraduate Medical Journal (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- The HKU Scholars Hub (University of Hong Kong) (submittedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Cancer Diagnosis and Treatment
- Health Sciences › Medicine › Pathology and Forensic Medicine › Ophthalmology and Eye Disorders
- Keywords
- hyperthyroidism in pregnancy, Graves' disease, struma ovarii, radioiodine therapy, ovarian cyst torsion, thyrotoxicosis
- MeSH terms
- Adult, Antibodies, Female, Graves Disease, Humans, Hyperthyroidism, Iodine Radioisotopes, Ovarian Neoplasms, Pregnancy, Pregnancy Complications, Pregnancy Complications, Neoplastic, Receptors, Thyrotropin, Struma Ovarii
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