The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Recurrent miscarriage: causes, evaluation and management
Abstract
Recurrent miscarriage is frustrating for the physician and a heartbreaking experience for the patient. Approximately 5% of couples trying to conceive have two consecutive miscarriages. Despite a thorough study of patients, the aetiology of this common obstetric complication is unknown in 50% of cases. Known causes include abnormal chromosomes, endocrinological disorders and uterine abnormalities. Although antiphospholipid antibodies have been demonstrated in miscarriages, the role played by alloimmune mechanisms remains unclear. New immunological approaches such as natural killer cells, regulatory T cells, tumour necrosis factor α, cell-derived microparticles, leptin, certain glycoproteins and cytokines should be considered. The management of thyroid diseases and immunological disorders is continuously evolving. Several genetic diagnostic procedures such as parental karyotyping and preimplantation genetic screening should probably not be used routinely. Antiphopholipid syndrome and some recurrent miscarriage-related endocrinological disorders can be effectively treated. Finally, new therapeutic approaches and the pleiotropic effects of old ones have led to improved fetal–maternal outcomes.
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Cites
MIYAKIS, S., LOCKSHIN, M. D., ATSUMI, T., BRANCH, D. W., BREY, R. L., CERVERA, R., DERKSEN, R. H. W. M., DE GROOT, P. G., KOIKE, T., MERONI, P. L., et al. (2006) · Journal of Thrombosis and Haemostasis · doi:10.1111/j.1538-7836.2006.01753.x · Cited by 7,203
Stagnaro-Green, A., Abalovich, M., Alexander, E., Azizi, F., Mestman, J., Negro, R., Nixon, A., Pearce, E. N., Soldin, O. P., Sullivan, S., et al. (2011) · Thyroid · doi:10.1089/thy.2011.0087 · Cited by 2,942
Maternal age and fetal loss: population based register linkage study
Andersen, A.-M. N. (2000) · BMJ · doi:10.1136/bmj.320.7251.1708 · Cited by 1,690
Rai, R., & Regan, L. (2006) · The Lancet · doi:10.1016/s0140-6736(06)69204-0 · Cited by 1,227
Fibroids and infertility: an updated systematic review of the evidence
Pritts, E. A., Parker, W. H., & Olive, D. L. (2009) · Fertility and Sterility · doi:10.1016/j.fertnstert.2008.01.051 · Cited by 913
Embryonic karyotype of abortuses in relation to the number of previous miscarriages
Ogasawara, M., Aoki, K., Okada, S., & Suzumori, K. (2000) · Fertility and Sterility · doi:10.1016/s0015-0282(99)00495-1 · Cited by 604
Immunotherapy for recurrent miscarriage
Wong, L. F., Porter, T. F., & Scott, J. R. (2014) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd000112.pub3 · Cited by 348
First-trimester low-dose prednisolone in refractory antiphospholipid antibody-related pregnancy loss
Bramham, K., Thomas, M., Nelson-Piercy, C., Khamashta, M., & Hunt, B. J. (2011) · Blood · doi:10.1182/blood-2011-02-339234 · Cited by 180
Saravelos, S. H., Yan, J., Rehmani, H., & Li, T.-C. (2011) · Human Reproduction · doi:10.1093/humrep/der293 · Cited by 98
Cited by
Role of maternal age and pregnancy history in risk of miscarriage: prospective register based study
Magnus, M. C., Wilcox, A. J., Morken, N.-H., Weinberg, C. R., & Håberg, S. E. (2019) · BMJ · doi:10.1136/bmj.l869 · Cited by 698
Chen, H., Yang, X., & Lu, M. (2016) · Archives of Gynecology and Obstetrics · doi:10.1007/s00404-015-3894-8 · Cited by 57
Metadata
- Authors
- Garrido-Gimenez, C., & Alijotas-Reig, J.
- Venue
- Postgraduate Medical Journal
- Publisher
- Oxford University Press (OUP)
- Published
- 2015-02-13
- Volume
- 91
- Issue
- 1073
- Pages
- 151-162
- ISSN
- 0032-5473 (ISSN-L)
- 1469-0756
- OpenAlex
- W2165623629
- Cited by
- 270
- References
- 9
- FWCI
- 5.50
- Type
- journal article
- Language
- en
- Open access
- closed
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- Garrido-Gimenez, C., & Alijotas-Reig, J. (2015). Recurrent miscarriage: causes, evaluation and management. Postgraduate Medical Journal. https://doi.org/10.1136/postgradmedj-2014-132672
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
