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Frequent paracetamol use and asthma in adults
Open accessAbstract
BACKGROUND: The pulmonary antioxidant glutathione may limit airway inflammation in asthma. Since paracetamol (acetaminophen) depletes the lung of glutathione in animals, a study was undertaken to investigate whether frequent use in humans was associated with asthma. METHODS: Information was collected on the use of analgesics as part of a population based case-control study of dietary antioxidants and asthma in adults aged 16-49 years registered with 40 general practices in Greenwich, South London. The frequency of use of paracetamol and aspirin was compared in 664 individuals with asthma and in 910 without asthma. Asthma was defined by positive responses to questions about asthma attacks, asthma medication, or waking at night with shortness of breath. The association between analgesic use and severity of disease amongst asthma cases, as measured by a quality of life score, was also examined. RESULTS: Paracetamol use was positively associated with asthma. After controlling for potential confounding factors the odds ratio for asthma, compared with never users, was 1.06 (95% CI 0.77 to 1.45) in infrequent users (
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“Depletion of glutathione in airway epithelial lining fluid by paracetamol metabolites has been suggested as the possible cause (192).”
From Paracetamol: New Vistas of an Old Drug (2006) · cites this paper as [192]
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“Finally, it is worth mentioning an increased evidence of asthma in chronic paracetamol users (17,192).”
From Paracetamol: New Vistas of an Old Drug (2006) · cites this paper as [192]
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Cited by
Sorted by citations
Glutathione dysregulation and the etiology and progression of human diseases
Ballatori, N., Krance, S. M., Notenboom, S., Shi, S., Tieu, K., & Hammond, C. L. (2009) · Biological Chemistry · doi:10.1515/bc.2009.033 · Cited by 1,145
“Recently, there has been growing interest in reports that associate acetaminophen use (a well-known GSH-depleting agent), with an increased risk of asthma (Shaheen et al., 2000; Barr et al., 2004; Eneli et al., 2005; McKeever et al., 2005).”
BackgroundParacetamol: New Vistas of an Old Drug
Bertolini, A., Ferrari, A., Ottani, A., Guerzoni, S., Tacchi, R., & Leone, S. (2006) · CNS Drug Reviews · doi:10.1111/j.1527-3458.2006.00250.x · Cited by 674
“Finally, it is worth mentioning an increased evidence of asthma in chronic paracetamol users (17,192).”
BackgroundBeasley, R. W., Clayton, T., Crane, J., von Mutius, E., Lai, C. K. W., Montefort, S., & Stewart, A. W. (2008) · The Lancet · doi:10.1016/s0140-6736(08)61445-2 · Cited by 429
Long‐term adverse effects of paracetamol – a review
McCrae, J. C., Morrison, E. E., MacIntyre, I. M., Dear, J. W., & Webb, D. J. (2018) · British Journal of Clinical Pharmacology · doi:10.1111/bcp.13656 · Cited by 308
“studies demonstrated a connection between paracetamol use and asthma diagnoses or exacerbations [47-54].”
BackgroundDietary Antioxidants and Asthma in Adults
SHAHEEN, S. O., Sterne, J. A. C., THOMPSON, R. L., SONGHURST, C. E., Margetts, B., & Burney, P. (2001) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.164.10.2104061 · Cited by 310
“After allowing for likely wrong addresses, the overall response rate was 55% ( 14 ).”
BackgroundSelf-citation
Metadata
- Authors
- Shaheen, S. O.
- Affiliations
- King's College London (GB)
- Corresponding author
- Shaheen, S. O
- ORCID
- Shaheen, S. O
- Venue
- Thorax
- Publisher
- BMJ
- Published
- 2000-04-01
- Volume
- 55
- Issue
- 4
- Pages
- 266-270
- ISSN
- 0040-6376 (ISSN-L)
- PMC
- PMC1745727
- OpenAlex
- W2025295475
- Cited by
- 226
- References
- 34
- Citations by year
- 2026: 1 · 2024: 2 · 2023: 1 · 2022: 5 · 2021: 5 · 2020: 6 · 2019: 6 · 2018: 6 · 2017: 5 · 2016: 6 · 2015: 6 · 2014: 12 · 2013: 14 · 2012: 9
- FWCI
- 8.80
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Thorax (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Research Portal (King's College London) (submittedVersion)
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Asthma and respiratory diseases
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Occupational exposure and asthma
- Health Sciences › Medicine › Pharmacology (medical) › Inflammatory mediators and NSAID effects
- Keywords
- paracetamol, asthma, aspirin, analgesic use, glutathione depletion, airway inflammation, dietary antioxidants, asthma severity, quality of life, adults
- MeSH terms
- Acetaminophen, Adolescent, Adult, Anti-Inflammatory Agents, Non-Steroidal, Aspirin, Asthma, Glutathione, United Kingdom, Humans, Male, Middle Aged, Risk Factors, Case-Control Studies, Analgesics, Non-Narcotic
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