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Cited by 449Chronic Obstructive Pulmonary Disease (COPD) ResearchAsthma and respiratory diseasesSmoking Behavior and Cessation

The DOI matches its Crossref record; 20 of the 21 references it cites were found in a registry or an index.

Risk of depression in patients with chronic obstructive pulmonary disease and its determinants

Open access
van Manen, J G·2002·Thorax
DOI 10.1136/thorax.57.5.412PMC PMC1746339
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Abstract

BACKGROUND: Although it has been repeatedly suggested that chronic obstructive pulmonary disease (COPD) is associated with depression, no conclusion has so far been reached. A study was undertaken to investigate whether depression occurs more often in patients with COPD than in controls. The demographic and clinical variables associated with depression were also determined. METHODS: Patients with a registered diagnosis of obstructive airway disease in general practice, aged > or=40 years, forced expiratory volume in 1 second (FEV(1)) <80% predicted, FEV(1) reversibility <or =12%, FEV(1)/VC < or = predicted - 1.64 x SD, and a history of smoking were selected. A random sample of subjects without a registered diagnosis of asthma or COPD aged 40 years or older acted as controls. Depression was assessed using the Centers for Epidemiologic Studies Depression (CES-D) scale. RESULTS: In patients with severe COPD (FEV(1) <50% predicted), the prevalence of depression was 25.0% compared with 17.5% in controls and 19.6% in patients with mild to moderate COPD. When the results were adjusted for demographic variables and comorbidity, the risk for depression was 2.5 times greater for patients with severe COPD than for controls (OR 2.5, 95% CI 1.2 to 5.4). In patients with mild to moderate COPD this increased risk of depression was not seen. Living alone, reversibility of FEV(1) % predicted, respiratory symptoms and physical impairment were significantly associated with the scores on the CES-D scale. CONCLUSION: Patients with severe COPD are at increased risk of developing depression. The results of this study underscore the importance of reducing symptoms and improving physical functioning in patients with COPD.

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  1. Siafakas NM, Vermeire P, Pride NB, et al. ERS consensus statement. Optimal assessment and management of chronic obstructive pulmonary disease. Eur Respir J 1995;8:1398-420.

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Metadata

Authors
van Manen, J. G.
Venue
Thorax
Publisher
BMJ
Published
2002-05-01
Volume
57
Issue
5
Pages
412-416
ISSN
0040-6376 (ISSN-L)
DOI
10.1136/thorax.57.5.412
PMC
PMC1746339
OpenAlex
W2139415488
Cited by
449
References
21
Citations by year
2026: 3 · 2025: 7 · 2024: 6 · 2023: 13 · 2022: 14 · 2021: 10 · 2020: 15 · 2019: 16 · 2018: 23 · 2017: 14 · 2016: 19 · 2015: 17 · 2014: 29 · 2013: 32 · 2012: 16
FWCI
15.31
Type
journal article
Language
en
Open access
Locations
  • Thorax (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • UvA-DARE (University of Amsterdam) (publishedVersion)
  • Pure Amsterdam UMC (publishedVersion)
  • Data Archiving and Networked Services (DANS) (submittedVersion)
  • Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
Funders
  • Universiteit Leiden
  • Universiteit van Amsterdam
Topics
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Chronic Obstructive Pulmonary Disease (COPD) Research
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Asthma and respiratory diseases
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Smoking Behavior and Cessation
Keywords
chronic obstructive pulmonary disease, depression, depression prevalence, disease severity, FEV1 reversibility, living alone, respiratory symptoms, physical impairment, comorbidities, risk factors, physical function
MeSH terms
Adult, Aged, Depressive Disorder, Female, Forced Expiratory Volume, Humans, Male, Middle Aged, Risk Factors, Vital Capacity, Pulmonary Disease, Chronic Obstructive

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