Exploration of a potent PI3 kinase/mTOR inhibitor as a novel anti-fibrotic agent in IPF
Mercer, Paul F, Woodcock, Hannah V, Eley, Jessica D, Platé, Manuela, Sulikowski, Michal G, Durrenberger, Pascal F, Franklin, Linda, Nanthakumar, Carmel B +10 more·2016·Thorax
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- 4E-BP1 acts as a molecular rheostat balancing regenerative healing and fibrotic scarringHanyu Dou, Jianzhou Li, Lin Lin, Mengyu Jin, Jingyuan Wang, Hequn Fu, Jiongming Lu, Qinyi Chen, 项蕾红, Juan Wang et al. · 2026 · Experimental & Molecular Medicine
- Computational Investigation of Mangifera indica Seed Kernel Extract Against Radiation Induced Pulmonary Fibrosis: In vivo PDGF/PI3K-AKT/GSK3β PathwayFatma A. Mokhtar, Nahla S. El‐Gazzar, Sebaey Mahgoub, Noha A. Fadel, Rania M. El‐Hazek, Walaa A. El‐Sabbagh · 2026 · Journal of Pharmaceutical Innovation
- Fibronectin's tensional state as a mechanical signature of fibrotic extracellular matrix in idiopathic pulmonary fibrosis modelsKonstantin M. P. Wolf, Emmanouil Angelidakis, Daria Künzli, David Lauer, Matthias Brunner, Alessia Cambria, Divya Vats, Britta Maurer, Viola Vogel B, Mamta Chabria · 2026 · Matrix Biology Plus
- BindingDB Entry 50018161: Targeting the PI3K/AKT/mTOR Signaling Pathway in the Treatment of Human Diseases: Current Status, Trends, and Solutions.BindingDB · 2024 · UC San Diego
- BindingDB Entry 50021579: Emerging opportunities to treat idiopathic pulmonary fibrosis: Design, discovery, and optimizations of small-molecule drugs targeting fibrogenic pathways.BindingDB · 2025 · UC San Diego
- BindingDB Entry 50007007: Discovery of 4-Methylquinazoline Based PI3K Inhibitors for the Potential Treatment of Idiopathic Pulmonary Fibrosis.BindingDB · 2021 · UC San Diego