The DOI matches its Crossref record; 100 of the 101 references it cites were found in a registry or an index.
Patient adherence in COPD
Open accessAbstract
Patient adherence to treatment in chronic obstructive pulmonary disease (COPD) is essential to optimise disease management. As with other chronic diseases, poor adherence is common and results in increased rates of morbidity, healthcare expenditures, hospitalisations and possibly mortality, as well as unnecessary escalation of therapy and reduced quality of life. Examples include overuse, underuse, and alteration of schedule and doses of medication, continued smoking and lack of exercise. Adherence is affected by patients' perception of their disease, type of treatment or medication, the quality of patient provider communication and the social environment. Patients are more likely to adhere to treatment when they believe it will improve disease management or control, or anticipate serious consequences related to non-adherence. Providers play a critical role in helping patients understand the nature of the disease, potential benefits of treatment, addressing concerns regarding potential adverse effects and events, and encouraging patients to develop self-management skills. For clinicians, it is important to explore patients' beliefs and concerns about the safety and benefits of the treatment, as many patients harbour unspoken fears. Complex regimens and polytherapy also contribute to suboptimal adherence. This review addresses adherence related issues in COPD, assesses current efforts to improve adherence and highlights opportunities to improve adherence for both providers and patients.
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“Previous studies suggested that the misuse or rejection of medication or NIV can be influenced by some psychological factors such as anxiety, depression, health beliefs, and cognitive impairment (27–29); the unacknowledged recognition of the illness; and the use of different devices and medications due to comorbidities (30–32).”
From Promoting Acceptance and Adherence to Noninvasive Ventilation in Chronic Obstructive Pulmonary Disease: A Randomized Controlled Trial. (2022) · cites this paper as [28]
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Cites
Vestbo, J., Hurd, S. S., Agustí, A. G., Jones, P. W., Vogelmeier, C., Anzueto, A., Barnes, P. J., Fabbri, L. M., Martinez, F. J., Nishimura, M., et al. (2013) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201204-0596pp · Cited by 15,983
Murray, C. J. L., & López, A. D. (1997) · The Lancet · doi:10.1016/s0140-6736(96)07492-2 · Cited by 7,007
Adherence to Long-Term Therapies: Evidence for Action
Geest, S. D., & Sabate, E. J. (2003) · European Journal of Cardiovascular Nursing · doi:10.1016/s1474-5151(03)00091-4 · Cited by 6,310
Global Initiative for Chronic Obstructive Lung Disease
Gerald, L. B., & Bailey, W. C. (2002) · Journal of Cardiopulmonary Rehabilitation · doi:10.1097/00008483-200207000-00004 · Cited by 5,806
DiMatteo, M. R., Lepper, H. S., & Croghan, T. W. (2000) · Archives of Internal Medicine · doi:10.1001/archinte.160.14.2101 · Cited by 4,177
Chronic Obstructive Pulmonary Disease
Flavin, K., Morkane, C. M., & Marsh, S. (2018) · Cambridge University Press eBooks · doi:10.1017/9781108233712.025 · Cited by 2,687
A systematic review of the associations between dose regimens and medication compliance
Claxton, A. J., Cramer, J., & Pierce, C. (2001) · Clinical Therapeutics · doi:10.1016/s0149-2918(01)80109-0 · Cited by 2,388
Buist, A. S., McBurnie, M. A., Vollmer, W. M., Gillespie, S., Burney, P., Mannino, D. M., Menezes, A. M., Sullivan, S. D., Lee, T. A., Weiss, K. B., et al. (2007) · The Lancet · doi:10.1016/s0140-6736(07)61377-4 · Cited by 2,364
DiMatteo, M. R. (2004) · Medical Care · doi:10.1097/01.mlr.0000114908.90348.f9 · Cited by 2,169
American Thoracic Society/European Respiratory Society statement on pulmonary rehabilitation
Nici, L., Donner, C., Wouters, E., Zuwallack, R., Ambrosino, N., Bourbeau, J., Carone, M., Celli, B., Engelen, M., Fahy, B., et al. (2006) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200508-1211st · Cited by 1,966
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Dual bronchodilation with QVA149versussingle bronchodilator therapy: the SHINE study
Bateman, E. D., Ferguson, G. T., Barnes, N. C., Gallagher, N. E., Green, Y., Henley, M., & Banerji, D. D. (2013) · European Respiratory Journal · doi:10.1183/09031936.00200212 · Cited by 384
“Features of QVA149 that may help to reduce non-adherence to treatment, which remains high in COPD [26] are the convenience of once-daily dosing [27] which is generally preferred by patients [26, 28, 29] and the need for only one single inhaler.”
BackgroundDransfield, M. T., Bourbeau, J., Jones, P., Hanania, N. A., Mahler, D. A., Vestbo, J., Wachtel, A., Martínez, F. J., Barnhart, F., Sanford, L., et al. (2013) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(13)70040-7 · Cited by 343
Self-citationDahl, R., Chung, K. F., Buhl, R., MAGNUSSEN, H., Ноников, В. Е., Jack, D., Bleasdale, P., Owen, R. J., Higgins, M., Krämer, B., et al. (2010) · Thorax · doi:10.1136/thx.2009.125435 · Cited by 272
“reversibility of 17%. Nevertheless, the present double-blind comparison shows that indacaterol is the more effective bronchodilator and is similar or more effective for clinical outcomes. In addition, patient adherence to a once-daily dosing regimen may be better than with a twice-daily regimen since frequency of dosi…”
BackgroundCox, N. S., Oliveira, C. C., Lahham, A., & Holland, A. E. (2017) · Journal of physiotherapy · doi:10.1016/j.jphys.2017.02.002 · Cited by 275
Mechanisms and impact of the frequent exacerbator phenotype in chronic obstructive pulmonary disease
Wedzicha, J. A., Brill, S., Allinson, J. P., & Donaldson, G. C. (2013) · BMC Medicine · doi:10.1186/1741-7015-11-181 · Cited by 254
“administered via different routes and devices, and adherence is therefore complex and difficult to measure; it may differ between therapies and even in individual patients [50].”
Background
Metadata
- Authors
- Bourbeau, J., & Bartlett, S. J.
- Affiliations
- McGill University Health Centre (CA)
- Johns Hopkins University (US)
- Corresponding author
- Bourbeau, J
- Venue
- Thorax
- Publisher
- BMJ
- Published
- 2008-09-01
- Volume
- 63
- Issue
- 9
- Pages
- 831-838
- ISSN
- 0040-6376 (ISSN-L)
- PMC
- PMC4747423
- OpenAlex
- W2138833643
- Cited by
- 490
- References
- 101
- Citations by year
- 2026: 9 · 2025: 16 · 2024: 25 · 2023: 22 · 2022: 24 · 2021: 32 · 2020: 30 · 2019: 24 · 2018: 42 · 2017: 34 · 2016: 37 · 2015: 23 · 2014: 37 · 2013: 41 · 2012: 24
- FWCI
- 2.80
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Thorax (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- HighWire Press Open Archive (submittedVersion)
- Funders
- McGill University
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01AR051351)
- Topics
- Health Sciences › Medicine › Family Practice › Medication Adherence and Compliance
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Chronic Obstructive Pulmonary Disease (COPD) Research
- Health Sciences › Health Professions › Pharmacy › Pharmacy and Medical Practices
- Keywords
- chronic obstructive pulmonary disease, medication adherence, patient-provider communication, self-management, polypharmacy, complex medication regimens, smoking, health care utilization, quality of life
- MeSH terms
- Attitude to Health, Communication, Humans, Patient Compliance, Perception, Professional-Patient Relations, Caregivers, Polypharmacy, Pulmonary Disease, Chronic Obstructive
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