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Comparative effects of inhaled leukotriene C4, leukotriene D4, and histamine in normal human subjects.
Open accessAbstract
The comparative actions of inhaled leukotriene C4 (LTC4), leukotriene D4 (LTD4), and histamine were studied in six normal subjects. LTC4 and LTD4 were shown to be more potent bronchoconstrictors than histamine, with a more sustained action. LTC4 and LTD4 caused wheezing without cough or throat irritation and were shown to act on large and small airways.
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Citations
Cited by
Roles of cysteinyl leukotrienes in airway inflammation, smooth muscle function, and remodeling
Holgate, S. T., Peters-Golden, M., Panettieri, R. A., & Henderson, W. R. (2003) · Journal of Allergy and Clinical Immunology · doi:10.1067/mai.2003.25 · Cited by 318
International Union of Pharmacology XXXVII. Nomenclature for Leukotriene and Lipoxin Receptors
Brink, C., Dahlén, S.-E., Drazen, J., Evans, J. F., Hay, D. W. P., Nicosia, S., Serhan, C. N., Shimizu, T., & Yokomizo, T. (2003) · Pharmacological Reviews · doi:10.1124/pr.55.1.8 · Cited by 286
Kemp, J. P., Dockhorn, R. J., Shapiro, G. G., Nguyen, H. H., Reiss, T. F., Seidenberg, B. C., & Knorr, B. (1998) · The Journal of Pediatrics · doi:10.1016/s0022-3476(98)70281-1 · Cited by 268
Vagal afferent nerves regulating the cough reflex
Canning, B. J., Mori, N., & Mazzone, S. B. (2006) · Respiratory Physiology & Neurobiology · doi:10.1016/j.resp.2006.03.001 · Cited by 260
Airway injury as a mechanism for exercise-induced bronchoconstriction in elite athletes
Anderson, S. D., & Kippelen, P. (2008) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2008.05.001 · Cited by 237
Metadata
- Authors
- Barnes, N. C., Piper, P. J., & Costello, J. F.
- Venue
- Thorax
- Publisher
- BMJ
- Published
- 1984-07-01
- Volume
- 39
- Issue
- 7
- Pages
- 500-504
- ISSN
- 0040-6376 (ISSN-L)
- OpenAlex
- W2066950125
- Cited by
- 304
- References
- 0
- FWCI
- 10.49
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Comparative effects of inhaled leukotriene C4, leukotriene D4, and histamine in normal human subjects. https://app.cochat.ai/papers/10.1136/thx.39.7.500
- The paper
- Barnes, N. C., Piper, P. J., & Costello, J. F. (1984). Comparative effects of inhaled leukotriene C4, leukotriene D4, and histamine in normal human subjects. Thorax. https://doi.org/10.1136/thx.39.7.500
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
